A5007791612- Hibiscus Plant Research Studies
- Natural Antidiabetic Agents Studies
- Cardiac Ischemia and Reperfusion
- Phytochemicals and Antioxidant Activities
- Natural Products and Biological Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Nicotinic Acetylcholine Receptors Study
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Cynara cardunculus studies
- Cancer Treatment and Pharmacology
- Garlic and Onion Studies
- Antioxidant Activity and Oxidative Stress
- Phytochemistry and biological activities of Ficus species
- Electron Spin Resonance Studies
- Curcumin's Biomedical Applications
- Cardiovascular Disease and Adiposity
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Renin-Angiotensin System Studies
- Signaling Pathways in Disease
- Nitric Oxide and Endothelin Effects
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Sirtuins and Resveratrol in Medicine
National University of Malaysia
2016-2025
University Kebangsaan Malaysia Medical Centre
2020-2023
University of Strathclyde
2016
Abstract Hypertension, or high blood pressure (BP), is a complex disease influenced by various risk factors. It characterized persistent elevation of BP levels, typically exceeding 140/90 mmHg. Endothelial dysfunction and reduced nitric oxide (NO) bioavailability play crucial roles in hypertension development. L‐NG‐nitro arginine methyl ester (L‐NAME), an analog L‐arginine, inhibits endothelial NO synthase (eNOS) enzymes, leading to decreased production increased BP. Animal models exposed...
Abstract Long-term nicotine intake is associated with an increased risk of myocardial damage and dysfunction. However, it remains unclear whether targeting mitochondrial reactive oxygen species (ROS) prevents nicotine-induced cardiac remodeling This study investigated the effects mitoTEMPO (a mitochondria-targeted antioxidant), resveratrol sirtuin activator) , on Sprague–Dawley rats were administered 0.6 mg/kg daily 0.7 mitoTEMPO, 8 resveratrol, or vehicle alone for 28 days. At end study,...
Doxorubicin (DOX) has been extensively utilized in cancer treatment. However, DOX administration adverse effects, such as cardiac injury. This study intends to analyze the expression of TGF, cytochrome c, and apoptosis on histology rats induced with doxorubicin, since prevalence cardiotoxicity remains an unpreventable problem due a lack understanding mechanism underlying result. Vernonia amygdalina ethanol extract (VAEE) was produced by soaking dried leaves ethanol. Rats were randomly...
The α7nAchR gene is expressed in immune cells, including macrophages, and linked to cardiovascular diseases. cardioprotective effects of activation against inflammation isoprenaline-induced myocardial injury are unclear. This study aims assess the α7nAChR on rats. We hypothesized that provides cardioprotection via cholinergic anti-inflammatory pathway. Isoprenaline hydrochloride (85 mg/kg) was injected subcutaneously rats induce activated a7nAchR through daily transcutaneous tragus...
Background The impact of adverse childhood experiences (ACEs) has been the focus most studies for past decade. There is an indication that developing resilience can help youth overcome these ACEs. Objective This article presents a study protocol randomized controlled trial (RCT) to investigate effects resilience-building intervention on psychological well-being, coping strategies, stress, quality life, resilience, resource finding, and among individuals affected with ACEs in Malaysia....
<title>Abstract</title> Cardiovascular disease is the primary cause of death in Malaysia, with post-menopausal women at higher risk due to oestrogen deficiency. Consequently, researchers are exploring alternative approaches minimize cardiovascular injury women. S-Allylcysteine (SAC), a compound aged garlic extract has demonstrated cardioprotective effects through mitochondrial preservation and CSE/hydrogen sulfide (H<sub>2</sub>S) pathway. This study investigated impact SAC ovariectomised...
Prolonged exposure to nicotine accelerates onset and progression of renal diseases in habitual cigarette smokers. Exposure nicotine, either via active or passive smoking is strongly shown enhance oxidative stress augment kidney failure various animal models. In this study, we investigated the effects resveratrol supplementation on nicotine-induced injury a rat model. Male Sprague-Dawley rats were given (0.6 mg/kg, i.p.) alone combination with (8 i.p.), angiotensin II type I receptor blocker,...
The aim of this study was to investigate the protective effects aqueous extracts roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell (RBC) membrane oxidative stress in rats with streptozotocin-induced diabetes.Forty male Sprague-Dawley weighing 230-250 g were randomly divided into four groups (n = 10 each): control group (N), roselle-treated group, diabetic and group. Roselle administered by force-feeding (100 mg/kg body weight) for 28 days.The results demonstrated that...
Nicotine is a major toxic and hazardous component of cigarette smoke, it has been widely used in nicotine replacement therapy (NRT). This study was aimed to investigate the effects chronic low-dose on sperm characteristics reproductive organ integrity adolescent male Sprague-Dawley rats.Twelve rats were equally divided into two groups. Group I received normal saline, group II 0.6 mg/kg body weight intraperitoneally for 28 consecutive days. At end experimental period, collected characteristic...