A5076440214- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Seaweed-derived Bioactive Compounds
- Medicinal Plants and Neuroprotection
- Natural product bioactivities and synthesis
- Chemotherapy-induced cardiotoxicity and mitigation
- Algal biology and biofuel production
- Phytochemical compounds biological activities
- Medicinal Plant Research
- Drug-Induced Hepatotoxicity and Protection
- Medicinal Plants and Bioactive Compounds
- Moringa oleifera research and applications
- Protein Hydrolysis and Bioactive Peptides
- Cardiac Ischemia and Reperfusion
- Chemotherapy-induced organ toxicity mitigation
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactivity Studies
- Nutrition, Genetics, and Disease
- Bioactive Compounds and Antitumor Agents
- Pomegranate: compositions and health benefits
- Biochemical effects in animals
- Diet and metabolism studies
- Herbal Medicine Research Studies
- Natural Compounds in Disease Treatment
University of North Sumatra
2019-2025
Sunan Kalijaga State Islamic University Yogyakarta
2025
Diponegoro University
2024
Abstract Hypertension, or high blood pressure (BP), is a complex disease influenced by various risk factors. It characterized persistent elevation of BP levels, typically exceeding 140/90 mmHg. Endothelial dysfunction and reduced nitric oxide (NO) bioavailability play crucial roles in hypertension development. L‐NG‐nitro arginine methyl ester (L‐NAME), an analog L‐arginine, inhibits endothelial NO synthase (eNOS) enzymes, leading to decreased production increased BP. Animal models exposed...
Context: Hyperglycemia is a significant contributor to the development of atherosclerosis and major risk factor. The process initiates with phosphorylation JAK1 JAK2, subsequently leading activation STAT3, which results in atherosclerotic damage vascular endothelial cells. Rhodomyrtus tomentosa an antioxidant botanical traditional medicine capacity mitigate oxidative stress. Aims: To analyze JAK family expression aorta tissue after administration R. tomentosa. Methods: A Completely...
Doxorubicin (DOX) has been extensively utilized in cancer treatment. However, DOX administration adverse effects, such as cardiac injury. This study intends to analyze the expression of TGF, cytochrome c, and apoptosis on histology rats induced with doxorubicin, since prevalence cardiotoxicity remains an unpreventable problem due a lack understanding mechanism underlying result. Vernonia amygdalina ethanol extract (VAEE) was produced by soaking dried leaves ethanol. Rats were randomly...
HIV/AIDS is still a major worldwide health concern, and Indonesia making efforts to mitigate its effects. Antiretroviral therapy (ARV), which aims decrease viral replication, boost immunological function, lengthen the lifespans of persons living with HIV/AIDS, cornerstone Indonesia’s strategy. The availability ARV has significantly increased, yet problems including stigma requirement for regular medication adherence exist. To address broader needs those affected by lays focus on...
Microalgae are a diverse group of microorganisms with wide range physical characteristics and interactions their surroundings. They hold great promise as strategic crops capable producing substantial quantities valuable biomolecules, such protein omega-rich oils, which have extensive applications across multiple industries. This perspective aims to provide an overview recent advancements in the utilization photobioreactors for large-scale cultivation microalgae. It also delves into...
Inhaling Allethrin (C19H26O3) may induce oxidative stress in lung cells by causing the formation of free radi-cals. Interleukins (IL) are a group secreted cytokines or proteins and signaling molecules initially produced as an immune response leukocytes. Rhodomyrtus tomentosa (Aiton) Hassk. (haramonting) contains antioxidants that prevent damage induced allethrin-containing electric mosquito repellents. In this study, six groups rats were exposed to allethrin via repellent, including...
Enhalus arcoides is a highly beneficial type of seagrass. Prior studies have presented proof the bioactivity E. acoroides, suggesting its potential to combat cancer. Therefore, this study aims delve deeper into acoroides bioactive molecule profiles and their direct biological anticancer activities potentials through combination in-silico in-vitro studies. This conducted metabolite profile analysis on utilizing HPLC-ESI-HRMS/MS analysis. Two extraction techniques, ethanol hexane, were...
Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide, underscoring the importance understanding diverse molecular and genetic underpinnings CRC to improve its diagnosis, prognosis, treatment. This review delves into adenoma-carcinoma-metastasis model, emphasizing "APC-KRAS-TP53" signature events in development. categorized four consensus subtypes, each characterized by unique alterations responses therapy, illustrating complexity heterogeneity. Furthermore, we explore...
Doxorubicin has been used as an anticancer drug and already indicated effective in the treatment of cancer. The incidence cardiotoxicity due to doxorubicin was approximately 11%, resulting limited use doxorubicin. Cardiac protection during therapy is needed because it can reduce heart failure. Vernonia amygdalina (VA) traditionally by Indonesians a traditional medicine contains many secondary metabolites, including vernolide, vernodalol, vernoamygdalin, vernolepin, luteolin, luteolin...
Squalene has been tested widely in pharmacological activity including anticancer, antiinflammatory, antioxidant, and antidiabetic properties. This study aims to examine of squalene silico vivo models. In the model, PASS server was used evaluate Meanwhile, model conducted on a Type 2 Diabetes Mellitus (T2DM) with rats separated into three groups. These include (160 mg/kgbw), metformin (45 diabetic control (DC) (aquades 10 mL/kgbw) administered once daily for 14 days. Fasting Blood Glucose...
The prevalence of breast cancer among patients in Indonesia is significant. Indonesian individuals maintain the belief that cannot be cured alone by pharmaceuticals and treatment; herbal remedies must used conjunction. Rhodomyrtus tomentosa , also known as Haramonting, an indigenous medicinal plant renowned for its copious antioxidant properties. objective study was to assess impact haramonting on examining expression various biomarker proteins associated with cancer. Haramonting...
The medicinal plant
Prostate cancer (PCa) is a malignancy characterized by abnormal cell proliferation in the prostate gland, critical component of male reproductive system. Atractylodes lancea DC. (ALD), medicinal herb commonly used traditional Asian medicine, highly regarded for its antioxidant, antidiabetic, and anticancer properties. Virtual docking stud-ies have identified Atractylenolide II III as active components ALD, demonstrating strong binding potential to inhibit androgen receptor (AR) activity,...