A5030880650- Public Health and Nutrition
- Cancer survivorship and care
- Medicinal Plant Research
- Mesenchymal stem cell research
- Wound Healing and Treatments
- Periodontal Regeneration and Treatments
- Bariatric Surgery and Outcomes
- COVID-19 and healthcare impacts
- Family Support in Illness
- Effects of Radiation Exposure
- Pancreatic and Hepatic Oncology Research
- Tannin, Tannase and Anticancer Activities
- Inflammatory Biomarkers in Disease Prognosis
- Metabolism, Diabetes, and Cancer
- Head and Neck Cancer Studies
- Moringa oleifera research and applications
- Pregnancy-related medical research
- Thyroid Cancer Diagnosis and Treatment
- Medical and Biological Ozone Research
- COVID-19 and Mental Health
- Cervical Cancer and HPV Research
- Cancer-related cognitive impairment studies
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- COVID-19 Prevention and Impact
Diponegoro University
2012-2025
Dr. Kariadi Hospital
2018-2025
Universitas Semarang
2022
Enhalus arcoides is a highly beneficial type of seagrass. Prior studies have presented proof the bioactivity E. acoroides, suggesting its potential to combat cancer. Therefore, this study aims delve deeper into acoroides bioactive molecule profiles and their direct biological anticancer activities potentials through combination in-silico in-vitro studies. This conducted metabolite profile analysis on utilizing HPLC-ESI-HRMS/MS analysis. Two extraction techniques, ethanol hexane, were...
Background: The objective of this study is to compare the effects between combination PECS Block II with GA and alone on inflammation levels in breast cancer, measure by Tumor Necrosis Factor-Alpha (TNF-α) red blood cell distribution width platelet ratio (RPR). Methods: Experimental analytical parallel randomized control trial was done 48 cancer patients who underwent removal surgery at Dr. Kariadi Hospital August – October 2023. Patients were randomly allocated into 2 groups, (GA only)...
Background This study aims to evaluate the association and dose-response between triglyceride-glucose (TyG) index breast cancer. Method is a multicenter case-control conducted in six public referral hospitals Indonesia. Cases are individuals aged 19 years or above who were diagnosed with cancer within 1 year of diagnosis, based on histopathology immunohistochemistry. Controls recruited from corresponding hospitals. TyG was determined by formula: ln (fasting TG [mg/dl] × fasting glucose...
The healing process of a full‐thickness wound involves complex cascade cellular responses to reverse skin integrity formation. These processes require growth factors, particularly platelet‐derived factor (PDGF). Conversely, hypoxic mesenchymal stem‐cell‐conditioned medium (HMSC‐CM)‐contained factors notably contribute acceleration healing. This study aims investigate the role HMSC‐CM in controlling serial levels PDGF associated with accelerated closure wounds. Twenty male Wistar rats wounds...
NF-κB inhibits apoptosis through induction of antiapoptotic proteins and suppression proapoptotic genes. Various chemotherapy agents induce translocation target gene activation. We conducted the present study to assess predictive value regarding pathologic responses after receiving neoadjuvant chemotherapy.We enrolled 131 patients with locally advanced invasive ductal breast carcinoma. Immunohistochemistry (IHC) was used detect expression. Evaluation response elaborated Ribero...
BACKGROUND: Mesenchymal stem cells (MSCs) have potent immunosuppressive properties to control systemic lupus erythematosus (SLE) disease by releasing several anti-inflammatory molecules, particularly indoleamine 2, 3-dioxygenase (IDO), and increasing regulatory T (Treg) innate adaptive immune cells. However, how MSCs release IDO modulate Treg in controlling B is poorly understood. Therefore, investigating IDO, Treg, following MSC administration SLE needed. AIM: This study aimed investigate...
Background: Superoxide dismutase (SOD) can be decreased and malondialdehyde (MDA) increased in patients with head neck cancer (HNC) as a result of reactive oxygen species (ROS) brought on by cisplatin. Astaxanthin is one the external antioxidants required to combat ROS raising SOD lowering MDA. The purpose this study demonstrate that astaxanthin raise lower MDA HNC caused Methods: 42 research subjects were randomly assigned two groups double-blind, randomized controlled trial pre-post test...
Background: Liver fibrogenesis will produce α-smooth muscle actin (α-SMA) expression and a continuous inflammatory process, seen through the neutrophil lymphocyte ratio (NLR). The combination of mesenchymal stem cells bovine colostrum is novel strategy for repairing hepatic fibrosis tissue. To assess to reduce α-SMA NLR levels in Wistar rats after 50% fibrotic liver resection. Methods: Thirty-six male were randomly divided into 6 groups (sham, control, colostrum, MSCs, MSCs combination)....
BACKGROUND: Andrographis paniculata has anti-inflammatory, anti-cancer, and immunomodulatory effects. Intercellular adhesion molecule-1 (ICAM-1) E-selectin are released in inflammatory conditions due to sepsis. In sepsis-associated fatalities, is strongly expressed on pulmonary microvasculature ICAM-1 endothelial cells, macrophages, lymphocytes. Therefore, this study was conducted analyze the protective effect of A. leaf extract against lung injury lipopolysaccharide (LPS)-induced sepsis...
This study aims to determine the effect of virtual reality content on comfort level cancer patients. used a quasi-experimental non-equivalent control group design and was conducted 60 The intervention uses "My Comfortable Environment," which developed based Kolcaba's theory. Comfort measured using Shortened General Questionnaire. Wilcoxon Mann-Whitney U tests were differences before after within between groups. There significant mean difference pre-test post-test in with P < .000, Z =...
Objective: To investigate the level of three drug resistance proteins; P-glycoprotein 1 (P-gp), nuclear factorkappa-light-chain-enhancer activated B cells (NF-κB) and aldehyde dehydrogenase isoform (ALDH1) expressionand their relationship to metastasis, recurrence survival in advanced breast cancer patients that received neoadjuvantchemotherapy. Methods: This study is a combination prospective retrospective cohort involving onehundred thirty one cases stage invasive have neoadjuvant...
Background: The COVID-19 pandemic affects all healthcare services, including cancer care. Consequently, our institution implemented several changes in accordance with the National guidelines for managing transmission. However, patients’ perception of such is unknown. objective this study to explore knowledge patients on COVID-19, their perceptions towards oncology service, and identify key elements that contribute level anxiety or comfort. Methods: Written questionnaires were given out...
Specific patterns of the hereditary breast and ovarian cancer (HBOC) syndrome are related to mutations in BRCA1 gene. One hundred unrelated patients were interviewed obtain clinical symptoms signs, pedigree familial history HBOC cancer. Subsequently, data calculated using Breast Ovarian Analysis Disease Incidence Carrier Estimation Algorithm (BOADICEA) risk prediction model. Patients with high score BOADICEA offered genetic testing. Eleven BOADICEA, 2 low patient's family members 15 controls...
Background The 1st, 2nd and small 3rd degree hemorrhoids are non-operatively treated by using anti-inflammatory plebotonic medicines, high fiber diet changing lifestyle. Graptophyllum pictum (L.) Griff (GP) is potential to be a hemorrhoid medicine (anti-inflammatory medicine) since its effect may related antioxidant property.
 ObjectiveTo elaborate the anti-oxidant of GP on experimental in male Wistar rats.
 MethodsA Randomized Controlled Trial Post-test only design hemorrhoid-like...
Background: Burn injuries remain the third cause of death in world. The treatment, management deep dermal burns is by applying topical medications like nanosilver collagen cream. Collagen widely used for wound healing, cell development, angiogenesis, and platelets' activation. This study observed effectiveness drug administration cream compared to silver sulfadiazine against healing reviewed based on neutrophils counts angiogenesis.Methods: represents an experimental a laboratory with...
Background: Breast cancer is the most common type of malignancy in women. Many studies report that characteristics and prognosis young-aged breast carcinoma are worse than old age. Data on Indonesia relatively lacking always needs updates.Objective: To determine incidence distribution based histological profiles clinical stage, as well association between molecular subtype with grade stage (<40 years old) at Dr. Kariadi General Hospital Center 2018-2020.Methods: This research was an...
Background: Thyroid cancer is ranked ninth among the most common type originating from endocrine glands globally, accounting for approximately 59.7% of cases in Asia. According to 2020 health data, thyroid twelfth Indonesia, comprising 13,114 cases. Despite number recorded, there a lack comprehensive data regarding condition country. Therefore, this research aimed describe profile Dr. Kariadi General Hospital Semarang.Methods: This descriptive was carried out using 154 medical records...
<title>Abstract</title> <bold>Background:</bold> Breast cancer (BC) is a global health concern with significant mortality rates, necessitating deep understanding of its molecular landscape. Objective: This study focuses on the prevalence phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations in Luminal A and B BC within Indonesian population. BC, characterized by estrogen receptor (ER) and/or progesterone (PR) positivity, face challenges endocrine therapy...
Introduction: Atherosclerosis is a cardiovascular disease which the leading cause of 16% world's total deaths. The main comorbidities atherosclerosis are obesity and diabetes mellitus. One surgery treatment that currently very often used Sleeve Gastrectomy. Gastrectomy most effective significant long-term therapy for weight loss preventing various such as heart disease. This study analyze effect sleeve gastrectomy on expression anti-inflammatory cytokines (TGF-β IL-10) in abdominal aorta...
To determine the effect of clove flower extract on healing time incision wounds, bacterial count and IL-10 levels in rats infected with MRSA.Method. Experimental study a post-test-only control group design that were given incisions their backs. Random allocation was carried out to divide Sprague Dawley into 6 groups (@5 rats). Healing assessed based length days, examined from blood then counted by culture using nutrient agar. venous measured an ELISA kit certified microbiologist. Data...
Background: Breast-related Symptom Questionnaire (BREAST-Q) has been globally used and validated to measure the outcomes among women undergoing various breast surgery. There was a lack of tools evaluate patient’s quality life satisfaction after mastectomy in Indonesia. In addition, most patients Indonesia may feel reluctant express their honest opinions regarding post-operative outcome openly. Prior this issue, study aims translate validate BREAST-Q Mastectomy Module into Bahasa Indonesia,...