Cisplatin is still used as a first-line medication for solid tumors. Nephrotoxicity serious side effect that can decrease renal function and restrict applicable doses. This research aimed to obtain the profile of cisplatin-induced nephrotoxicity its associated factors in adult cancer patients at Dharmais National Cancer Hospital (DNCH).The design was cross-sectional with data obtained from patient medical records. We retrospectively reviewed treated cisplatin ≥60mg/m2 least four consecutive...

Human beings are often being exposed to carcinogenic factors during their life, some of which the nutritional factors. From mechanistic view, classified into genotoxic and non-genotoxic agents. Genotoxic agent begins action at DNA level, causing damage through several mechanisms, e.g. gene point mutations, deletions insertions, recombinations, rearrangements amplifications, as well chromosomal aberrations. Most agents micro components nutrition, i.e. polycyclic aromatic hydrocarbon (PAH) or...

Background This study aims to evaluate the association and dose-response between triglyceride-glucose (TyG) index breast cancer. Method is a multicenter case-control conducted in six public referral hospitals Indonesia. Cases are individuals aged 19 years or above who were diagnosed with cancer within 1 year of diagnosis, based on histopathology immunohistochemistry. Controls recruited from corresponding hospitals. TyG was determined by formula: ln (fasting TG [mg/dl] × fasting glucose...

Breast cancer subtypes can be categorized based on their gene expression profiles using immunohistochemistry into Luminal A, B, human epidermal growth factor receptor 2-positive (HER2+), and triple-negative breast (TNBC) subtypes. However, has certain limitations that lead to misclassification. DNA methylation is an epigenetic modification, changes in the promoter region alter quantity of functional protein synthesized, disrupting function. The aim this study was identify biomarkers for...

Previous studies found that cigarette smoke (CS) exposure could induce NSCLC malignancy and miRNA dysregulation. Yet, the association of CS-induced dysregulation has not been clearly understood. This study aimed to evaluate effect CS in smokers on expression miR-10b-5p miR-320b extracellular vesicles (EVs) from patients. Bioinformatic analysis was conducted validate candidates. Blood tissue samples were collected patients (n = 21) with smoking non-smoking history. EVs isolated plasma miRNAs...

Abstract Background Squamous cell carcinoma of the oral cavity (OSCC) is sixth most common malignancy. Surgery mainstay treatment for cancers. in locally advanced OSCC presents many challenges primarily because head and neck have critical structures that can be damaged by tumor or treatment. It thought neoadjuvant chemotherapy (NC) able to shrink size. Chemoresistancy a problem due hypoxic microenvironment characterized increased expression HIF-1α. also regulated miR-210 as well CD44 CD133....

Around 70% of breast cancers (BCs) are estrogen receptor-α (ERα)-positive. Adjuvant endocrine therapy is used to reduce levels and inhibit signal transduction through the ER. The anti-estrogen drugs that most commonly in belong selective ER modulator (SERM) class include tamoxifen. Although it has been for three decades cases early-stage ERα-positive BC, resistance tamoxifen a common problem. microRNAs (miRNAs) have potential role demonstrating BC therapy. Hence, there need investigate...

Most studies on advance care planning in Asia originate high-income Asian countries. Indonesia is a middle-income country characterized by its religious devoutness and strong family ties. This study aims to explore the perspectives experiences of Indonesian healthcare professionals for cancer patients.Focus-group discussions were conducted July August 2019 analysed using thematic content analysis enhanced dual coding exploration divergent views. Purposive sampling physicians nurses actively...

Most patients with non-small cell lung cancer (NSCLC) are diagnosed in advanced-stage disease and therefore have poor overall survival. It remains unclear whether nutritional status affects response rate survival NSCLC patients. This study aimed to evaluate the association of treatment advanced stage NSCLC.Patients aged ≥18 years II-IV (January-June 2018) a national center Indonesia were enrolled this study. The followed up for 2 since diagnosis was established. Clinical data including age,...

Background: Tongue cancer is still a major health problem in most developing countries around the world. Statistics shown number of tongue cancers, especially early age, to be increasing, with poor survival. Objective: To analyze characteristic profile patients Indonesia as well survival rate. Materials and Methods: A cross sectional study was conducted Dharmais National Cancer Hospital by collecting general, clinical, data from medical records for January 2009 April 2012. Results: incidence...

The high mortality rate in breast cancer (BC) patients is generally due to metastases resistant systemic therapy. Two causes of therapy resistance BC are circulating miRNAs-221 and miR-222, leading improved cell proliferation, survival, reduced apoptosis. This study investigated the miRNA expression changes associated with tamoxifen expected be clinically meaningful before providing endocrine luminal-type who express them.

Indonesia has a potency to produce its own propolis, however the propolis market in is dominated by imported product, such as from Brazil. Currently, still there no reasearch which evaluate bioactive compound and nutrient content of Indonesian Propolis (IP) compare with Brazilian (BP). The objectives this study were analyze compounds contents IP compared BP. Bioactive nutrients analyzed gas chromatography–mass spectrophotometry. results<br />showed both BP contain fenol, α-amyrin,...

Introduction: Anemia is a common blood disorder in the elderly which associated with numerous poor medical outcomes. However, there currently no study that assesses anemia prevalence of Indonesian population aged ≥60 years old multiple provinces and analyzes its association handgrip muscle strength using large sample size.

Background: Even though rarely found in Indonesia, the incidence of multiple myeloma (MM) is increasing every year. Bone involvement MM most often a clinical disorder which leads to worsening conditions and low quality life patients. Purpose: To determine clinicopathology profile bone patients Indonesia. Materials Methods: The cross-sectional study conducted at Dharmais National Cancer Hospital (DNCH) by collecting data from medical records who came DNCH period 2008-2012. Results: There were...

In this study, we aimed to investigate whether FIB-4 index is useful in predicting mortality patients with concurrent hematological malignancies and COVID-19. We also determine the optimal cut-off point for prediction.This a single-center retrospective cohort study conducted Dharmais National Cancer Hospital, Indonesia. Consecutive sampling of adults COVID-19 was performed between May 2020 January 2021. screening test using reverse transcriptase polymerase chain reaction (RT-PCR)...

BACKGROUND: Despite advances in lung cancer treatment, most cancers are diagnosed at an advanced stage. Expression of microRNA10b (miR-10b) and fibrinolytic activity, as reflected by soluble urokinase-type plasminogen activator receptor (suPAR) inhibitor 1 (PAI-1), promising biomarker candidates. OBJECTIVE: To assess the expression miR-10b, serum levels suPAR PAI-1 stage non-small cell (NSCLC) patients, their correlation with progression, treatment response prognosis. METHODS: The present...

Iron overload is a major problem in both transfusion-dependent (TDT) and non-transfusion-dependent thalassemia (NTDT). It has been known to increase oxidative stress. Meanwhile, blood transfusion as main therapy for increases iron overload. One of the markers stress malondialdehyde (MDA). This study aims provide data on MDA levels adult patients, compare before after patients with TDT NTDT.This cross-sectional, pre-post intermedia that received or without iron-chelating agents Cipto...

EGFR-tyrosine kinase inhibitors (EGFR-TKIs) were used to treat non-small cell lung cancer (NSCLC) patients with EGFR mutation positive. This study aims compare the effectiveness of first line TKIs; gefitinib, erlotinib, and afatinib in treatment advanced stage NSCLC positive Indonesian population.A retrospective cohort 88 treated gefitinib (n=59), erlotinib (n=22), (n=7) was performed national hospital Indonesia.Inclusion criteria IIIb or IV adenocarcinoma subtype. Subjects less than 18...

AbstractBackground Nutritional intake in adolescent girls Indonesia has been well studied, but there little study on its influence serum estradiol levels. A high level associated with higher risk of breast carcinogenesis.Objective To evaluate the dietary factors concentration girls.Methods community-based survey was conducted female junior school students Jakarta from January 2014 to 2015. assessed by semi-quantitative food frequency questionnaires (FFQ), which included total energy (kcal),...

Objective: This study aimed to investigate the associations of CD8+, PARP, and EGFR expressions with two-year survival in patients triple-negative breast cancer (TNBC). Methods: A retrospective cohort was conducted a national center. All aged 18 years diagnosed TNBC (2013-2017) were included followed for 24 months or until deceased. Kaplan-Meier function Cox proportional hazard model applied analyses. Results: The population (2,692 person-months, N = 126). At end follow-up, 27 mortality rate...

Non-small cell lung cancer (NSCLC) is the most common found in elderly patients. Aging and chronic inflammation are related to its pathogenesis. Functional status, lymphocyte-to-monocyte ratio platelet-to-lymphocyte describe a correlate survival of older adults with advanced-stage (IIIB-IV) NSCLC. This study aims determine functional as prognostic factors 1-year patients NSCLC stage IIIB-IV.

Pendahuluan. Salah satu terapi dari kanker paru jenis Non-Small Cell Lung Cancer (NSCLC) stadium lanjut adalah kemoterapi. Jenis kemoterapi yang sering digunakan di Indonesia cisplatin- toposide dan cisplatin-docexatel. Tolak ukur keberhasilan pengobatan kesintasan Progression Free Survival (PFS). Keberhasilan dipengaruhi oleh banyak faktor, seperti resistensi terhadap sitostatika, dosis, intensitas pemberian, kemoterapi, histologi, stadium, perfoma status, komorbiditas sosial ekonomi. Di...