Vernonia amygdalina Delile (Asteraceae) is used in traditional medicine to treat diabetes mellitus, and some research provides its activity breast cancer. The aim of this study assess the anticancer leaves fractions on 4T1 cancer cells. Analysis phytochemical compounds were carried out with LC-MS/MS. Cytotoxic was determined using MTT method cell line. Apoptosis, cycle, PI3K mTOR profiles analyzed flow cytometry. phytochemicals found diterpene (ingenol-3-angelate) phenolics (chlorogenic acid...

Cellulose nanofibers (CNFs), chitosan, and silver nanoparticles (AgNPs) are widely used to enhance the active functions antibacterial properties of wound dressings. This study was conducted prepare CNF/AgNP-chitosan using a straight incorporation method assess its antimicrobial activity. CNFs were isolated from oil palm empty fruit bunches (OPEFBs) pulping acid hydrolysis. AgNPs synthesized green synthesis method. The dressing produced by mixing 10% CNF solution in LiCl/DMAc AgNP-chitosan...

Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide, underscoring the importance understanding diverse molecular and genetic underpinnings CRC to improve its diagnosis, prognosis, treatment. This review delves into adenoma-carcinoma-metastasis model, emphasizing "APC-KRAS-TP53" signature events in development. categorized four consensus subtypes, each characterized by unique alterations responses therapy, illustrating complexity heterogeneity. Furthermore, we explore...

Growth, development, and structural changes within the Universitas Sumatera Utara Arboretum since its establishment in 2005 should be recognized, observed, investigated. Previously, site of this arboretum was oil palm plantation. The objective study is to map, classify, identify, calculate potency vegetation arboretum. Method research combination literature field work. In research, study, visit, inventory work were reported. Results revealed that at least 56 species forestry plants found...

Neisseria gonorrhoeae, the causative agent of gonorrhoea, is a major public health concern due to its widespread prevalence and rising antibiotic resistance. In addition genital infections, N. gonorrhoeae can cause gonococcal conjunctivitis, an ocular infection that lead severe complications such as blindness. To better understand pathogenesis conjunctivitis investigate potential therapeutic strategies, this study aimed establish reliable animal model using Wistar rat (Rattus norvegicus)....

Oriental Journal of Chemistry is a peer reviewed quarterly research journal pure and applied chemistry. It publishes standard papers in almost all thrust areas current chemistry academic commercial importance. provides platform for rapid publication quality papers, reviews letters. abstracted indexed reputed National International agencies.

Background: Secondary metabolites from the group of isoprenoid compounds are widely distributed in mangrove plants. Polyisoprenoids (dolichol and polyprenol) known to have benefits as anticancer agents. The present study was conducted determine cytotoxic potential polyisoprenoids leaves seventeen selected species against colon cancer (WiDr) cells. Methods: Cytotoxic activity evaluated by MTT assay vitro using WiDr human cells 3T3 fibroblasts Swiss albino mouse embryo tissue controls....

Objective: This study was carried out to investigate the antimigration activity of Zanthoxylum acanthopodium DC. in 4T1 breast cancer cell line. Methods: fruit powder extracted by maceration method with n-hexane and ethylacetate solvents. Cytotoxicity proliferation were assessed using MTT cycle flow cytometry. In addition, wound healing assays conducted a microscopic method, expression COX-2 VEGFR-2 determined qRT-PCR. Results: The IC50 fraction (EAF) 48.1 ± 1.06 μg/mL. EAE at concentration...

Objectives: The current investigation was conducted to examine the anticancer effect of polyisoprenoids from Avicennia marina and lanata leaves in WiDr cells. Selectivity index (SI), cell cycle inhibition, apoptosis activity were evaluated. Materials Methods: A. determined by observing these compounds toward cells using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide assay. SI IC50 polyisoprenoid extract normal (Vero) versus cancer (WiDr). Inhibited increased analyzed flow...

Abstract. Basyuni M, Wasilah Hasibuan PAZ, Sulistiyono N, Sumardi, Bimantara Y, Hayati R, Sagami H, Oku H. 2019. Salinity and subsequent freshwater influences on the growth, biomass, polyisoprenoids distribution of Rhizophora apiculata seedlings. Biodiversitas 20: 388-395. This study described (polyprenol dolichol) seedlings under saline fresh water treatment. Propagules R. were collected from Pulau Sembilan, Langkat, North Sumatra grown in 0.0%, 0.5%, 1.5%, 2.0%, 3.0% salt concentrations...

Individuals diagnosed with cancer often turn to the use of herbal remedies intention treating and ameliorating condition, impeding progression metastasis, enhancing immune function, mitigating stress, inducing relaxation. Recently, medicinal plants were combined conventional chemotherapy decrease side effects increase effectiveness chemotherapy. This study showed gemcitabine (Gem) was significantly increased after being used together ethyl acetate extract obtained from Vernonia amygdalina...

This study evaluates the therapeutic efficacy and safety of Vernonia Amygdalina extract (VAEE) in treating colorectal cancer (CRC) induced by azoxymethane/dextran sulfate sodium (AOM/DSS) mice to elucidate underlying mechanisms. The utilized a mouse model CRC assess impact VAEE on pathological markers, inflammatory mediators, oxidative stress. Phytochemical profiling was conducted using LC-HRMS, focusing phenolic compounds. extract's antioxidant activity quantified, its profile verified...

Vernonia amygdalina Delile, coming from the Asteraceae tribe, contains active compounds that can treat breast cancer. This study examines anticancer activity of Delile leaves, an fraction MCF-7/HER-2 cancer cells. Thin-layer chromatography determines phytochemical screening. Cytotoxic and proliferation analyses were determined using MTT method for cell line. The cycle apoptosis profiles examined flow cytometry. results be summarized in this study: a flavonoid with great potential...

BACKGROUND: The use of medicinal plants is increasing in several decades for relief many diseases. Indonesia consists thousands islands with various and the manners community using as a treatment every disease traditionally.
 AIM: Cytotoxic activity ethyl acetate fraction (EAF) Zanthoxylum acanthopodium fruit was tested towards T47D breast cancer cells.
 METHODS: vitro cytotoxic performed by MTT assay, result expressed IC50 (Inhibitory Concentration), cell cycle inhibition...

Lung cancer is one type of with the high incidence rate in world, and it very important to find best treatment therapy reduce problem lung cancer.African leaves (Vernonia amygdalina Delile.)have long been used as medicine world health.This study evaluated anticancer activity ethylacetate extract (EAE) Vernonia Delile.leaves towards HTB-182 cell line.EAE was analyzed for flavonoids constituent tested cytotoxicity, cycle inhibition, apoptosis induction inhibition PI3KCA, EGFR VEGFR-2 genes...

Objectives: Plectranthus amboinicus (Lour.) Spreng. is a plant which has the potential as an anti-cancer agent. To enhance bioavailability of extract, it necessary to transform extract into nanoparticles. This research aimed create nanoparticles and investigate anti-proliferative pro-apoptosis effects on T47D breast cancer cell lines. Materials Methods: The extraction with ethanol was performed using maceration method. were prepared by ionic gelation Cytotoxic assay method evaluation...

Colorectal cancer is the third most common world wide and has been occurred more in developing regions. The use of conventional chemotherapy agents may lead to various adverse effects. Therefore, it required find potential drug for anticancer from alternative source natural product including mangrove plants. present study was conducted determine activity polyisoprenoids Avicennia alba Blume. leaves (PAL) WiDr cells. Cell cycle inhibition, apoptosis activity, suppression cyclooxygenase-2...

This study was carried out to investigate cytotoxic activity towards T47D, 4T1, MCF-7, HeLa, and Raji cells of alkaloid fractions Zanthoxylum acanthopodium DC. fruits. DC.The fruit extracted by maceration. The ethanol extract fractionated with liquid-liquid extraction using n-hexane, chloroform at pH 3, 7, 9 obtained fractions. Cytotoxic for fraction 7 determined MTT assay.The IC50 (92.67 ± 1.37; 71.87 1.04; 159.87 0.63; 123.39 0.81; 103.09 0.58 µg/mLfor 7) (451.29 25.48; 247.18 2.82; 318.46...