Temperature dependent stepwise self-assembly and seeded supramolecular polymerization of a peptide amphiphile form metastable nanoparticles to single nanofibers or twisted bundles, render mechanically tunable hydrogel.

Herein, we report the efficient exfoliation of MoS2 in aqueous medium by short cationic peptide nanotubes featuring nucleating core (17) LVFFA(21) β-amyloid (Aβ 1-42), a sequence associated with Alzheimer's disease. The role morphology, length, and nature amyloid surface on exfoliation/dispersions were investigated through specific mutations sequences. Notably, owing to properties both constituents, self-assembled soft nanostructures , hybrid dispersions responded reversibly various stimuli,...

Peptide hydrogels have recently emerged as potential biomaterials for designing synthetic scaffolds in tissue engineering. We demonstrate pathway-controlled self-assembly of peptide amphiphile 1 to furnish kinetically controlled nanofibers (1NF) and thermodynamically stable twisted helical bundles (1TB). These supramolecular nanostructures with varied persistence lengths promote situ mineralization yield templated bioactive glass composites, 1NFBG 1TBBG – resorbable, mesoporous, degradable...

The Aβ42 amyloid-inspired peptide fragment renders pathway-driven self-assembled nanostructures mediated by heat, light and chemical cues. They are envisaged as robust biocatalysts with remarkable variation of the hydrolase catalytic efficiency.

Abstract The present study reports the development of a unique class Cytochrome C (CytC)‐loaded cross‐beta amyloid nanohybrids. peroxidase activity bound CytC increased up to two orders magnitude in organic solvents compared unbound water. sequences used feature nucleating core 17 LVFF 21 beta (Aβ), which assembled form homogenous fibers and nanotubes. morphology exposed surface nanohydrids critically modulated activity. A CytC–Ac‐KLVFFAE‐NH 2 hybrid featuring nanofiber showed 308‐fold...

The spontaneous formation of supramolecular metallo-hydrogels showing multi stimuli-responsiveness and intrinsic self-healing properties upon the interaction chiral-histidine with Zn²⁺ ions.

Chirality-driven self-sorting in peptide nanofibers that exhibits enantioselective enzymatic degradation for <sc>l</sc>-peptide fibers over their <sc>d</sc>-counterparts as visualized by super-resolution microscopy.

Reinforcement owing to inner stress formation is of supreme importance in life and the basis for biomechanical pathways, especially contractile materials resembling muscles. Cells strengthen their contiguous matrix by pulling thin actin filaments associated with bundles myosin molecular motors promoting rapid fluidization dynamic stiffening cytoskeleton. Herein, we demonstrate an elegant synthetic design a peptide–polymer conjugate network that exhibits multiple hierarchical control over its...

Peptide 1 with an Aβ42 amyloid nucleating core and a photodimerizable 4-methylcoumarin moiety at its N terminus demonstrates the step-wise self-assembly in water to form nanoparticles, eventual transformation into 1D nanofibers. Addition of γ-cyclodextrin subsequent irradiation UV light 320 nm resulted morphological conversion free-standing 2D nanosheets mediated by host-guest interaction. Mechanical agitation nanostructures led seeds narrow polydispersity indices, which mediation seeded...

Abstract The present study reports the development of a unique class Cytochrome C (CytC)‐loaded cross‐beta amyloid nanohybrids. peroxidase activity bound CytC increased up to two orders magnitude in organic solvents compared unbound water. sequences used feature nucleating core 17 LVFF 21 beta (Aβ), which assembled form homogenous fibers and nanotubes. morphology exposed surface nanohydrids critically modulated activity. A CytC–Ac‐KLVFFAE‐NH 2 hybrid featuring nanofiber showed 308‐fold...

Synthetic systems mimicking the natural self-folding process are attractive to impart multiple structural control over polymer crosslinking and subsequent alteration of their macroscopic self-healing properties. In that regard, polymers P1-P5 containing pendant photo-crosslinkable moieties were designed underwent intra- or interchain collapse form diverse nanostructures. The shape dimension nanostructures could be efficiently controlled by concentration, solvent compatibility characteristics...

Abstract Herein, we report the efficient exfoliation of MoS 2 in aqueous medium by short cationic peptide nanotubes featuring nucleating core 17 LVFFA 21 β‐amyloid (Aβ 1–42), a sequence associated with Alzheimer's disease. The role morphology, length, and nature amyloid surface on exfoliation/dispersions were investigated through specific mutations sequences. Notably, owing to properties both constituents, self‐assembled soft nanostructures , hybrid dispersions responded reversibly various...

Synergistic control of photo-responsive dynamic covalent and non-covalent interaction over the chain collapse single thermo-responsive polymers towards cargo localization augmented release.

A simple molecular framework obtained by cross-linking a hydrophobic chain with S,S- and R,R-tetritol the copper-catalysed azide-alkyne cycloaddition reaction is found to serve as an excellent bioisostere for self-assembly. The hexadecyl-linked triazolyl tetritol composite spontaneously self-assembles in n-hepane methanol form hierarchical organogels. Microscopic analyses X-ray diffraction studies demonstrate eventual formation of nanotubes through lamellar assembly amphiphiles. rheological...

We have developed a unique class of MoS2 entrapped aqueous gels where the exfoliated sheets trigger physical cross-linking nanofibers peptide amphiphiles. Strikingly, these show acute responsiveness towards near infra-red light (804 nm), an unprecedented observation for molecular hydrogels.

Extracellular matrix (ECM) elasticity remains a crucial parameter to determine cell-material interactions (viz. adhesion, growth, and differentiation), cellular communication, migration that are essential tissue repair regeneration. Supramolecular peptide hydrogels with their 3-dimensional porous network tuneable mechanical properties have emerged as an excellent class of ECM-mimetic biomaterials relevant dynamic attributes bioactivity. Here, we demonstrate the design minimalist...

Despite the recent wide investigation on active cancer drug delivery, there are still strong medical unmet needs for tumor‐environment responsive delivery in terms of spatiotemporal control. Herein, a biohybrid system pH‐responsive peptide nanotubes (PNTs)‐coated microalgae response to is developed. The amphiphilic PNTs effectively used encapsulate drugs and coat living C. reinhardtii by electrostatic interactions. drug‐loaded PNTs‐based maintain agile movement with phototaxis behavior....

Efficacy and durability of the photovoltaic device mandates its protection against hot, humid weather condition, high energy UV light unwanted scratches. Such challenges can be mitigated by smart polymeric coating with inherent properties e.g. hydrophobicity to prevent moisture, optimal viscocity for better processibility crack-healing. The hydrophobic polymers TP1-TP4 containing pendant photo-crosslinkable thymine moieties are designed that undergo [2 + 2] photocycloaddition upon UVB...

The de novo design and synthesis of peptide-based biocatalysts that can mimic the activity natural enzymes is an exciting field with unique opportunities challenges. In a enzyme, active site composed assembly different amino acid residues, often coordinated metal ion. A metalloenzyme’s catalytic results from dynamic concerted interplay various interactions among residues ions. Aiming to such enzymes, simple peptide fragments, drawing structural inspiration be utilized as model. our effort...

Numerous peptides have been utilized to explore the efficacy of their self-assembly produce nanostructures mimic self-organization capability biomolecules in nature. Self-assembled significant applicability for a range diverse applications. While ability create self-assembled functional materials has greatly improved, process, which results ordered 0D, 1D, and 2D nanostructures, is still time-consuming. Moreover, situ structural transformation from one structure another with different...

Amyloid fibril formation is a central biochemical process in pathology and physiology. Over decades, substantial advances were made elucidating the mechanisms of amyloidogenesis, its links to disease, production functional supramolecular structures. While term "amyloid" denotes starch-like features these assemblies, no evidence amyloidogenic behavior polysaccharides has been so far reported. Here, we investigate potential amylum (starch) not only self-assemble into hierarchical fibrillar...