A5074389378- Medical Imaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Orthopedic Infections and Treatments
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Psychedelics and Drug Studies
- Advanced MRI Techniques and Applications
- Forensic Toxicology and Drug Analysis
- Anesthesia and Sedative Agents
- Infective Endocarditis Diagnosis and Management
- Epilepsy research and treatment
- Medical Imaging and Pathology Studies
- Molecular Biology Techniques and Applications
- Education, Healthcare and Sociology Research
- Receptor Mechanisms and Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Orthopaedic implants and arthroplasty
- Nicotinic Acetylcholine Receptors Study
- Anesthesia and Neurotoxicity Research
- Neuroendocrine Tumor Research Advances
- Nuclear Physics and Applications
- Neurological disorders and treatments
- Science, Research, and Medicine
- Consumer Attitudes and Food Labeling
- Organometallic Complex Synthesis and Catalysis
Aalborg University Hospital
2014-2024
Aalborg University
2013-2024
Klinik und Poliklinik für Nuklearmedizin
2015-2020
Andalusian Health Service
2018
Faculty (United Kingdom)
2016
Plasmatreat (Germany)
2013
University of Copenhagen
2013
Aarhus University Hospital
1990-2009
Aarhus University
2003-2009
Istituto Pasteur
2008
Introduction . 177 Lu-OPS201 is a high-affinity somatostatin receptor subtype 2 antagonist for PRRT in patients with neuroendocrine tumors. The aim to find the optimal scaling dosimetry and compare biokinetics of animals humans. Methods Data on were analyzed athymic nude Foxn1 nu mice (28 F, weight: 26 ± 1 g), Danish Landrace pigs (3 F-1 M, 28 kg), 61 17 kg) administered activities 0.19–0.27 MBq (mice), 97–113 (pigs), 850–1086 (patients). After euthanizing (up 168 h), organ-specific activity...
Summary In a double‐blind, randomised trial the efficacy and safety of Ro 15‐1788, new benzodiazepine antagonist, was assessed in forty adults undergoing gastroscopy under diazepam sedation. Criteria were degree sedation anterograde amnesia. There significantly faster recovery patients after injection 0.61.0 mg 15‐1788 than placebo. Patients awake shortly but remained drowsy or asleep placebo administration. no side effects note.
Abstract Positron emission tomography (PET) studies with radiolabeled dopamine D 2 ‐like receptor ligands reveal d ‐amphetamine‐evoked increases in the competition from endogenous dopamine. However, corresponding effects of methylenedioxymethamphetamine (MDMA, “Ecstasy”), which releases catecholamines and also serotonin, are unknown. Using PET, we measured binding potentials ( pB s) benzamide [ 11 C]raclopride butyrophenone N‐[ C]methylspiperone ([ C]NMSP) brain living pigs first a baseline...
Summary The efficacy and safety of flumazenil were assessed in comparison to placebo a double‐blind randomised study 31 adults intoxicated with benzodiazepines. criteria the degree sedation, orientation time space. Patients who received awoke within minutes but central depression returned partly one hour later, which reflects short elimination half‐life drug. Side effects few results indicate that is effective primary management benzodiazepine overdose states where benzodiazepines have been...
Abstract The psychostimulant 3,4‐methylendioxymethamphetamine (MDMA, “ecstasy”) evokes degeneration of telencephalic serotonin innervations in rodents, nonhuman primates, and human recreational drug users. However, there has been no alternative to primates for studies the cognitive neurochemical consequences depletion a large‐bodied animal. Therefore, we used positron emission tomography (PET) with [ 11 C]DASB map distribution plasma membrane transporters brain Göttingen minipigs, first...
In patients with impaired liver function and hepatic encephalopathy (HE), consistent elevations of blood ammonia concentration suggest a crucial role in the pathogenesis HE. Ammonia acetate are metabolized brain both primarily astrocytes. Here, we used dynamic [(11)C]acetate PET to measure contribution astrocytes previously observed reduction oxidative metabolism cirrhosis HE, compared without healthy subjects. We new kinetic model estimate uptake from astrocyte [(11)C]acetate. No...
In a double–blind, randomized trial, the efficacy and safety of flumazenil, benzodiazepine antagonist, was evaluated in patients after gastroscopy under midazolam or diazepam sedation. The criteria were degree sedation anterograde amnesia. Flumazenil significantly reduced both groups without significant intergroup differences. No sign resedation found during observation period 3 h. amnesia effectively antagonized groups. well tolerated. is safe effective antagonist which makes it possible to...
177Lu is used in peptide receptor radionuclide therapies for the treatment of neuroendocrine tumors. Based on recent literature, SST2 antagonists are superior to agonists tumor uptake. The compound OPS201 novel somatostatin antagonist showing highest affinity. aim this study was measure vivo biodistribution and dosimetry 177Lu-OPS201 five anesthetized Danish Landrace pigs as an appropriate substitute humans quantitatively assess absorbed doses future clinical applications. obtained with a...
The psychoactive properties of the hallucinogen LSD have frequently been attributed to high affinity interactions with serotonin 5HT2 receptors in brain. Possible effects on dopamine D2/3 receptor availability not previously investigated living Therefore, we used PET map binding potential (pB) [11C]raclopride brain three pigs, first a baseline condition, and again at 1 4 h after administration (2.5 μg/kg, i.v.). There was progressive treatment effect striatum, where pB significantly reduced...
The activity of both isozymes monoamine oxidase (MAO) is reduced by 50% in the brain human smokers. We hypothesized that this not an epiphenomenon, but should bring about potentiation action psychostimulant drugs. To test hypothesis, we carried out serial positron emission tomography (PET) studies Göttingen miniature pigs to measure binding MAO-A ligand [11C]harmine and changes [11C]raclopride evoked a low dose amphetamine (0.7 mg/kg as free base, i.v.), first baseline condition, and, one...
The imaging of infectious and inflammatory diseases using gallium-67 (67Ga) citrate scintigraphy has been a well-established diagnostic tool for decades. In recent times, interest focused on PET the short-lived positron emitting radioisotope 68Ga. 68Ga is not only more readily available, it also provides better quality images whose high resolution permits quantitative analyses, thus improving management patients suffering from infections or inflammation. purpose our study was to develop fast...