A5005923405- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Turbomachinery Performance and Optimization
- Heat Transfer Mechanisms
- Trace Elements in Health
- Fluid Dynamics and Turbulent Flows
- Metabolism and Genetic Disorders
- Combustion and flame dynamics
- Drug Transport and Resistance Mechanisms
- Computational Fluid Dynamics and Aerodynamics
- Cardiac pacing and defibrillation studies
- Heavy Metal Exposure and Toxicity
- Lipid Membrane Structure and Behavior
- Organ Transplantation Techniques and Outcomes
- Erythrocyte Function and Pathophysiology
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Plasma Applications and Diagnostics
- Pediatric Hepatobiliary Diseases and Treatments
- Plasma and Flow Control in Aerodynamics
- Neonatal Health and Biochemistry
- Renal function and acid-base balance
- Atrial Fibrillation Management and Outcomes
- Heat Transfer and Optimization
- Clinical Nutrition and Gastroenterology
Aarhus University Hospital
2015-2024
Aarhus University
2008-2024
École Polytechnique Fédérale de Lausanne
2009-2022
ERN RARE-LIVER
2021
ERN GUARD-Heart
2021
University College South Denmark
2021
University of Southern Denmark
2021
University of Salzburg
2011-2020
Salzburg University of Applied Sciences
2012-2020
Weatherford College
2020
Cerebral edema leading to cerebral herniation (CH) is a common cause of death in acute liver failure (ALF). Animal studies have related ammonia with this complication. During failure, hepatic removal can be expected determine the arterial level. In patients ALF, we examined hypotheses that high later by CH, and impaired circulation ammonia. Twenty-two ALF were studied retrospectively. addition, prospective vein catheterization performed after development encephalopathy (HE) 22 9 on chronic...
The clinical course of alcoholic cirrhosis, a condition with high mortality, has not been well described. We examined prevalence, risk, chronology, and mortality associated three complications cirrhosis: ascites, variceal bleeding, hepatic encephalopathy. followed population-based cohort 466 Danish patients diagnosed cirrhosis in 1993–2005, starting from the date hospital diagnosis ending August 2006. Data were extracted medical charts during follow-up period. Risk calculated using...
To examine whether glucose ingestion during exercise affects the release of interleukin-6 (IL-6) from contracting limb, seven men performed 120 min semi-recumbent cycling on two occasions while ingesting either 250 ml a 6.4 % carbohydrate (GLU trial) or sweet placebo (CON beverage at onset of, and 15 intervals throughout, exercise. Muscle biopsies obtained before immediately after were analysed for glycogen IL-6 mRNA expression. Blood samples simultaneously brachial artery femoral vein prior...
Implantable devices, often dependent on software, save countless lives. But how secure are they?
1. Human erythrocyte acetylcholinesterase was solubilized by Triton X-100 and purified affinity chromatography to a specific activity of 3800 IU/mg protein. The yield the enzyme 25--45%. 2. Gel filtration on Sepharose 4-B in presence revealed one peak with Stokes' radius 8.7 nm. Density gradient centrifugation 0.1% showed an S4 value 6.3S. 3. Isoelectric focusing resolved into five molecular forms isoelectric points 4.55, 4.68, 4.81, 4.98 5.18. Upon incubation neuraminidase first four...
Patients with alcoholic cirrhosis are at higher risk for hepatocellular carcinoma (HCC). The role of HCC surveillance these patients is undefined.To provide population-based estimates incidence and comparisons HCC-related mortality total among as a basis assessing the surveillance.Nationwide, registry-based, historical cohort study.Denmark.All Danish citizens first-time hospital diagnosis from 1993 to 2005.Hepatocellular starting 1 year after through 2009; ratio mortality.Among 8482...
In patients with primary biliary cholangitis (PBC), the efficacy of budesonide, a synthetic corticosteroid displaying high first-pass metabolism, is unresolved. placebo-controlled, double-blind trial, we evaluated added-value budesonide in those PBC and ongoing risk progressive disease despite ursodeoxycholic acid (UDCA) treatment.We 62 who had histologically confirmed hepatic inflammatory activity, according to Ishak score, an alkaline phosphatase (ALP) >1.5× upper limit normal (ULN), after...
Abstract Copper transporting P-type (P 1B-1 -) ATPases are essential for cellular homeostasis. Nonetheless, the E1-E1P-E2P-E2 states mechanism of P -ATPases remains poorly understood. In particular, role intrinsic metal binding domains (MBDs) is enigmatic. Here, four cryo-EM structures and molecular dynamics simulations a -ATPase combined to reveal that in many eukaryotes MBD immediately prior ATPase core, −1 , serves structural role, remodeling ion-uptake region. contrast, −2 likely assists...
Physical exercise results in the appearance of heat shock protein (HSP) 72 circulation that precedes any increase gene or expression contracting skeletal muscle. In rodents, increases liver HSP72 and hepatosplanchnic viscera are known to release many acute phase proteins. present study, we tested hypothesis splanchnic tissue beds during exercise. Seven male subjects performed 120 min semi‐recumbent cycling at 62 ± 2 % maximal oxygen uptake. Blood samples were obtained simultaneously from a...
OBJECTIVE: In acute liver failure (ALF), urea production is severely impaired, and detoxification of ammonia by glutamine synthesis plays an important protective role. The aim this study was to examine the effects therapeutic high-volume plasmapheresis (HVP) on arterial concentrations splanchnic exchange rates ammonia, urea, amino acids—in particular, glutamine. METHODS: A quantity 8 L plasma exchanged over course 7 h in 11 patients with ALF after development hepatic encephalopathy grade...
Animal studies and results from 13N-ammonia positron emission tomography (PET) in patients with cirrhosis minimal hepatic encephalopathy suggest that a disturbed brain ammonia metabolism plays pivotal role the pathogenesis of (HE). We studied kinetics 8 an acute episode clinically overt HE (I-IV), 7 without HE, 5 healthy subjects, using contemporary dynamic PET. Time courses were obtained 13N-concentrations cerebral cortex, basal ganglia, cerebellum (PET-scans) as well arterial 13N-ammonia,...
Hyperammonaemia is a key pathological feature of liver disease and the primary driver hepatic encephalopathy (HE). However, relative roles increased ammonia production reduced clearance are poorly understood as action ammonia-targeting drugs for HE. We aimed to quantify whole-body metabolism in healthy persons patients with cirrhosis validate our method by examining effects glycerol phenylbutyrate lactulose + rifaximin treatment.Ten men ten male were investigated 90-minute constant infusion...
Clinical and experimental studies suggest that the proteins of extracellular actin scavenger system have a role in pathophysiological processes taking place critically ill injured patients. Circulating levels Gc-globulin gelsolin are reduced shortly after severe trauma, admission associated with survival. Herein, we sought to measure association between postinjury organ dysfunction infection. We also wanted describe serial changes these severely patients.Prospective cohort.Intensive care...