A5022504541- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Metabolism and Genetic Disorders
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Cerebrospinal fluid and hydrocephalus
- Pharmacological Effects and Toxicity Studies
- Bacterial Infections and Vaccines
- Epilepsy research and treatment
- Neurosurgical Procedures and Complications
- Anesthesia and Neurotoxicity Research
- Clinical Nutrition and Gastroenterology
- Liver Diseases and Immunity
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Alcoholism and Thiamine Deficiency
- Optical Imaging and Spectroscopy Techniques
- Thermal Regulation in Medicine
- Monoclonal and Polyclonal Antibodies Research
- Neurological Complications and Syndromes
- Hemodynamic Monitoring and Therapy
- Atomic and Subatomic Physics Research
Aarhus University
2025
Rigshospitalet
2013-2023
Copenhagen University Hospital
2007-2023
ERN RARE-LIVER
2023
University of Copenhagen
2005-2022
Capital Region of Denmark
2012
University of Cape Town
2011
Statens Serum Institut
1978-2009
Queen Elizabeth Hospital Birmingham
2009
Hvidovre Hospital
2009
Cerebral edema leading to cerebral herniation (CH) is a common cause of death in acute liver failure (ALF). Animal studies have related ammonia with this complication. During failure, hepatic removal can be expected determine the arterial level. In patients ALF, we examined hypotheses that high later by CH, and impaired circulation ammonia. Twenty-two ALF were studied retrospectively. addition, prospective vein catheterization performed after development encephalopathy (HE) 22 9 on chronic...
Acute-on-chronic liver failure (ACLF) is a frequent cause of death in cirrhosis. Albumin dialysis with the molecular adsorbent recirculating system (MARS) decreases retained substances and improves hemodynamics hepatic encephalopathy (HE). However, its survival impact unknown. In all, 189 patients ACLF were randomized either to MARS (n=95) or standard therapy (SMT) (n=94). Ten (five per group) excluded due protocol violations. addition, 23 (MARS: 19; SMT: 4) from per-protocol (PP) analysis...
Extracorporeal albumin dialysis (ECAD) may improve severe hepatic encephalopathy (HE) in patients with advanced cirrhosis via the removal of protein or non–protein-bound toxins. A prospective, randomized, controlled, multicenter trial efficacy, safety, and tolerability ECAD using molecular adsorbent recirculating system (MARS) was conducted such patients. Patients were randomized to standard medical therapy (SMT) SMT alone. provided daily for 6 hours 5 days until patient had a 2-grade...
Background and Purpose —Under normal circumstances, autoregulation maintains cerebral blood flow (CBF) constant within a wide range of mean arterial pressure (MAP). It remains unknown whether patients resuscitated from cardiac arrest have preserved CBF autoregulation. In this study, was investigated the first 24 hours after resuscitation arrest. Methods —Eighteen 6 healthy volunteers had relative changes in determined by transcranial Doppler velocity (V ) middle artery during stepwise rise...
This study validates transcranial Doppler sonography (TCD) for determination of the lower limit cerebral blood flow (CBF) autoregulation and establishes a relation between global CBF mean velocity (Vmean) in middle artery. Relative changes Vmean were compared 12 normal volunteers (2 women 10 men; median age, 30 years [range, 21 to 61 years]). Catheters was placed left radial artery bulb right internal jugular vein, respectively. Baseline measured by single-photon emission computed tomography...
Arterial blood pressure and cardiac output are often reduced in patients with chronic heart failure (CHF). Counterregulatory mechanisms increased neurohormonal activation changes the distribution of assumed to secure vital organ perfusion. However, clinical examination CHF frequently reveals neurological symptoms dizziness memory problems, suggesting altered brain In this study we determined whether cerebral flow (CBF) is New York Heart Association (NYHA) functional class III IV (n=12)...
The aim of the study is to evaluate effect a single treatment with molecular adsorbents recirculating system (MARS) on systemic hemodynamics and oxygen consumption (VO2) in patients hyperacute liver failure (HALF). In controlled design, eight HALF were assigned 6-hour MARS treatment, five patients, control group that was mechanically cooled match group. Systemic hemodynamic variables determined hourly during period. group, vascular resistance index increased by 46% from 1,215 ± 437 1,778 710...
In this prospective study of patients with fulminant hepatic failure (FHF), we tested the hypothesis that arterial hyperammonemia results in cerebral accumulation osmotic active amino acids glutamine and alanine, processes were expected to correlate intracranial pressure (ICP). By using vivo brain microdialysis technique together ICP monitoring 17 FHF (10 females/7 males; median age 49 (range 18 66) years), found ammonia concentration correlated content ( r=0.47; P > 0.05) but not...
Abstract The Model for End-Stage Liver Disease (MELD) scoring system has been established as a reliable measure of short-term mortality risk in patients with end-stage chronic liver disease. aim this study was to evaluate the prognostic value MELD predictor fulminant hepatic failure (FHF) and death acetaminophen poisoning. Prospectively, serial measurements 3 components—INR, bilirubin, creatinine—were performed 460 acetaminophen-induced injury. Starting on first day after overdose, score...
<title>Abstract</title> Breast milk is the optimal nutrition for infants, yet individual variations in its composition and effects on infant growth remain unclear. This study examined human (HM) metabolome microbiome dynamics relation to gut (GM) maturation 164 exclusively breastfeeding Danish mother-infant dyads over first three months. Results showed distinct temporal shifts HM as well GM composition. Maternal pre-pregnancy BMI correlated with metabolite profiles, growth, diversity...
Uncontrolled increase in intracranial pressure (ICP) continues to be one of the most significant causes early death patients with acute liver failure (ALF). In this study, we aimed determine effects indomethacin on ICP and cerebral perfusion twelve ALF brain edema (9 females/3 males, median age 49,5 (range 21 64) yrs.). Also changes determined by transcranial Doppler technique (Vmean) jugular bulb oxygen saturation (SvjO2) were measured, as well content lactate glutamate microdialysis...
Patients with advanced cirrhosis and ascites are characterized by circulatory dysfunction splanchnic vasodilatation renal vasoconstriction, which often lead to ascites. The vasoconstrictor terlipressin improves function in hepatorenal syndrome (HRS). aim of this study was evaluate if also patients without HRS. Twenty-three participated; 15 nonrefractory were randomized either (N group, n = 11) or a placebo (P 4), 8 had refractory received (R group). glomerular filtration rate (GFR), sodium...
OBJECTIVE: In acute liver failure (ALF), urea production is severely impaired, and detoxification of ammonia by glutamine synthesis plays an important protective role. The aim this study was to examine the effects therapeutic high-volume plasmapheresis (HVP) on arterial concentrations splanchnic exchange rates ammonia, urea, amino acids—in particular, glutamine. METHODS: A quantity 8 L plasma exchanged over course 7 h in 11 patients with ALF after development hepatic encephalopathy grade...
Hyperlactatemia has been suggested as a prognostic marker in acetaminophen-induced fulminant hepatic failure, and modification of the King's College Hospital criteria to incorporate arterial lactate measurements recently proposed. The aims present study were further evaluate failure analyze its relationship known causes hyperlactatemia such multiple organ inflammation.Data collected early after admission again at time onset grade 3-4 encephalopathy from failure. Multiple inflammatory...
To determine the efficacy of tacrolimus on clinical status, histopathological status and biochemical markers in patients with steroid refractory autoimmune hepatitis (AIH).Retrospectively, parameters, biochemistry histology were obtained from patient records.Nine [8 females/1 male, median age 32 (range 16-64) years] identified to have received for a duration 18 (12-37) mo. Before initiation treatment maintained prednisolone dose 20 mg daily 20-80 mg/d), which was tapered 7.5 (5-12.5) mg/d...