A5017253770- Cancer-related Molecular Pathways
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Anesthesia and Neurotoxicity Research
- Renal Diseases and Glomerulopathies
- Cancer Mechanisms and Therapy
- Inflammasome and immune disorders
- Autoimmune Bullous Skin Diseases
- HER2/EGFR in Cancer Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Muscle and Compartmental Disorders
- Tryptophan and brain disorders
- Intensive Care Unit Cognitive Disorders
- Electrolyte and hormonal disorders
- Vasculitis and related conditions
- Fibroblast Growth Factor Research
- PI3K/AKT/mTOR signaling in cancer
- Bone and Joint Diseases
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- Chronic Lymphocytic Leukemia Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bipolar Disorder and Treatment
- Anesthesia and Sedative Agents
Xijing Hospital
2012-2025
Air Force Medical University
2012-2025
AbstractHuman mitochondrial Mrs2 protein (hsaMrs2p) is a magnesium transporter in mitochondria inner membrane. It was identified as an upregulated gene multidrug-resistant (MDR) gastric cancer cell line compared to its parental cells by subtractive hybridization. To further explore the role of hsaMrs2p MDR cells, cDNA encoding generated and mouse antisera against raised with recombinant immunogen. HsaMrs2p expression could positively regulate adriamycin resistance SGC7901/ADR both vitro...
Here we presented that the expression of RUNX3 was significantly decreased in 75 cases clear cell renal carcinoma (CCRCC) tissues (p<0.05). Enforced mediated 786-O cells to exhibit inhibition growth, G1 cell-cycle arrest and metastasis vitro, lost tumorigenicity nude mouse model vivo. RUNX3-induced growth suppression found partially regulate various proteins, including cyclinD1, cyclinE, cdk2, cdk4 p-Rb, but increase p27(Kip1), Rb TIMP-1. Therefore, had function inhibiting proliferative...
The incidence of concurrent immunoglobulin A nephropathy and membranous (cIgAN/MN) is low rarely reported, the prognosis patients with cIgAN/MN remains unclear. This study was designed to compare clinical prognostic characteristics IgAN MN identify crucial factors influencing outcomes cIgAN/MN.
541 Background: PI3K pathway activation is associated with primary resistance of trastuzumab in patients HER2-positive metastatic breast cancer. It remains to be not fully understood how this correlates sensitivity and lapatinib pretreated anthracyclins, taxanes, trastuzumab. Methods: Sixty-seven cancer were recruited into a global Expanded Access Program 57 have tumor specimens available for determination status. PTEN status was determined by immunohistochemical staining PIK3CA mutations...
The mortality rate for people with brain injuries is increased when hypernatremia present. Patients severe hypernatremia, who have a significant short-term rate, were shown to benefit from continuous venovenous hemofiltration (CVVH), which has been indicated be successful. Exploring the risk factors in injury patients underwent CVVH and had was aim of current study.Retrospective screening performed on at Xijing Hospital between 1 December 2010 31 2021 diagnosis hypernatremia. outcomes...