A5032280848- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Kruppel-like factors research
- Galectins and Cancer Biology
- Bone and Joint Diseases
- Endometriosis Research and Treatment
- Bone and Dental Protein Studies
- Chemokine receptors and signaling
- MicroRNA in disease regulation
- Hematological disorders and diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Cancer Mechanisms and Therapy
- Genetic Syndromes and Imprinting
- Genomic variations and chromosomal abnormalities
- Circular RNAs in diseases
Xijing Hospital
2023-2024
Tianjin Medical University General Hospital
2020-2024
Air Force Medical University
2023-2024
Karamay Central Hospital
2024
Xi'an Medical University
2023
Beijing University of Chinese Medicine
2023
Jiangyin People's Hospital
2018
Hunan Normal University
2006-2014
University of Toronto
2012-2013
University Health Network
2010-2013
Summary High expression of the inhibitory receptor programmed cell death ligand 1 (PD-L1) on tumor cells and stromal have been found to play a key role in immune evasion several human malignancies. However, PD-L1 bone marrow mesenchymal stem (BMSCs) whether (PD-1)/PD-L1 signal pathway is involved BMSCs versus T response multiple myeloma (MM) remains poorly defined. In this study, we explored from newly diagnosed MM (NDMM) patients PD-1/PD-L1 BMSC-mediated regulation CD8+ cells. The data...
As an important negative regulatory factor of immunological cells, Tim3 plays a regulating role in tumor immune microenvironment. The purpose this study was to investigate the expression on MM cells and its effect proliferation apoptosis as well potential mechanism.In study, detected myeloma (CD38+CD138+ cells) bone marrow by flow cytometry (FCM) from 167 patients with 51 healthy donors controls making correlation analysis related clinical indexes. In vitro, cell lines (RPMI-8226 U266) were...
KCTD10 is a member of the PDIP1 family, which highly conserved during evolution, sharing lot similarities among human, mouse, and zebrafish. Recently, zebrafish KCTD13 has been identified to play an important role in early development brain autism. However, specific function remains be elucidated. In this study, experiments were carried out determine expression pattern mRNA embryonic development. It was found that maternal gene great importance shaping heart blood vessels. Our data provide...
Noncoding RNA (ncRNA) is involved in the occurrence, development, metastasis, and drug resistance of tumors involves a variety biological functions. In addition, miRNA can regulate proliferation migration even epigenetics to promote development multiple myeloma (MM). However, mechanism ncRNA MM still unclear, there are many unknown ncRNAs be explored. This research aimed at discovering lncRNA through high‐throughput sequencing study role competitive endogenous (ceRNA) pathogenesis for novel...
TCRαβ+ CD4−CD8−NK− double negative T cells (DN cells) can act as regulatory to inhibit allograft rejection and autoimmunity. Their role in graft-versus-host disease mechanisms of suppression remain elusive. In this study, we demonstrate that DN CD4+ cell-mediated GVHD a semi-allogeneic model bone marrow transplantation. Furthermore, present evidence novel autocrine IFNγ signaling pathway Fas-deficient C57BL/6.lpr (B6.lpr) cells. B6.lpr lacking or its receptor were impaired their ability...
Prediction of microRNA–mRNA interaction typically relies on bioinformatic methods, but these methods only suggest the possibility microRNA binding and may miss important interactions as well falsely predict others. A major obstacle to miRNA research has been lack experimental procedures for identification miRNA–mRNA interactions. Recently, a few studies have attempted explore isolate identify targets or miRNAs targeting single gene. Here, we developed an more convenient approach isolation...
Multiple myeloma (MM) is a clonal disorder characterized by the proliferation of plasma cells and their accumulation within bone marrow (BM). The flow cytometric analysis an essential method for hematological diseases because high sensitivity.This study evaluates indication role malignant plasmacytes (PCs) in BM detected cytometry risk stratification MM.Whole samples from 92 newly diagnosed MM patients were included study. We collected 106 each sample cytometry. Then we analyzed correlation...
Patients with autoimmune lymphoproliferative syndrome (ALPS) and lymphoproliferation (LPR) mice are deficient in Fas, accumulate large numbers of αβ-TCR+, CD4−, CD8− double negative (DN) T cells. The function these DN cells remains largely unknown. common γ subunit the activating Fc receptors, FcRγ, plays an important role mediating innate immune responses. We have shown previously that a significant proportion express this molecule is required for TCR transgenic to suppress allogeneic...
To investigate the clinical significance of three-step approach in laparoscopic hemihepatectomy.A total 32 patients received hemihepatectomy with Yijishan Hospital affiliated to Wannan Medical College between Aug 2013 and Oct 2015. All underwent thin slice CT scan was imitated imagic explorer, preoperatively. The vessel distribution observed at section used hemihepatectomy. Pre- post-operative data were collected analyzed retrospectively.The length middle hepatic vein (MHV) (59.1±12.9) mm...
To provide high-quality clinical evidence of the efficacy Tibetan medicine Honghua Ruyi (HHRY) pills for endometriosis-associated dysmenorrhea. This study constitutes a multicenter, randomized, double-blind, placebo-controlled trial encompassing three-menstrual cycle intervention followed by follow-up period. A total 164 eligible females with dysmenorrhea were randomly divided into HHRY and placebo groups in 1:1 ratio. The primary outcome included symptoms assessed using Visual Analog Scale...