A5070250336- Hearing, Cochlea, Tinnitus, Genetics
- Autism Spectrum Disorder Research
- Air Quality and Health Impacts
- Genetics and Neurodevelopmental Disorders
- Innovations in Medical Education
- Anatomy and Medical Technology
- Noise Effects and Management
- Hearing Loss and Rehabilitation
- Animal Vocal Communication and Behavior
- Congenital heart defects research
- Biochemical Analysis and Sensing Techniques
- Health, Environment, Cognitive Aging
- Neural dynamics and brain function
- Neurological disorders and treatments
- Air Quality Monitoring and Forecasting
- Medical and Biological Sciences
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Energy and Environment Impacts
- Proteoglycans and glycosaminoglycans research
- COVID-19 impact on air quality
- Pharmacological Effects and Toxicity Studies
- Surgical Simulation and Training
- Nerve Injury and Rehabilitation
- Empathy and Medical Education
Lake Erie College of Osteopathic Medicine
2015-2024
University of Montana
2016
West Virginia University
2000-2006
Wojskowy Instytut Higieny i Epidemiologii
1968-1978
Millions of children in polluted cities are showing brain detrimental effects. Urban exhibit structural and volumetric abnormalities, systemic inflammation, olfactory, auditory, vestibular cognitive deficits v low-pollution controls. Neuroinflammation blood-brain-barrier breakdown target the olfactory bulb, prefrontal cortex brainstem, but diffusely present throughout brain. adolescent Apolipoprotein E4 carriers significantly accelerate Alzheimer pathology. Neurocognitive effects air...
The superior paraolivary nucleus (SPON) is a prominent of the olivary complex. In rats, this composed morphologically homogeneous population GABAergic neurons that receive excitatory input from contralateral cochlear and inhibitory ipsilateral medial trapezoid body. SPON provide dense projection to inferior colliculus are thereby capable exerting profound modulatory influence on collicular neurons. Despite recent interest in structural connectional features SPON, little presently known...
Abstract We assessed brainstem inflammation in children exposed to air pollutants by comparing auditory evoked potentials (BAEPs) and blood inflammatory markers age 96.3 ± 8.5 months from highly polluted ( n = 34) versus a low city 17). The brainstems of nine with accidental deaths were also examined. Children the environment had significant delays wave III t (50) 17.038; p < 0.0001) V 19.730; but no delay I 0.548). They significantly longer latencies than controls for interwave intervals...
Exposures to fine particulate matter PM2.5 and ozone O3 are associated with Alzheimer's disease (AD) risk. Mexico City residents have lifetime exposures above annual USEPA standards their brains contain high redox, combustion, friction-derived magnetite nanoparticles. AD pathological changes subcortical pre-tangle stages in infancy cortical tau pre-tangles, NFT Stages I-II, amyloid phases 1-2 identified by the 2nd decade. Given continuum, a reliable identification of cognitive impairment is...
Autism spectrum disorder (ASD) is a neurodevelopmental characterized by repetitive behaviors, poor social skills, and difficulties with communication. Beyond these core signs symptoms, the majority of subjects ASD have some degree auditory vestibular dysfunction. Dysfunction in sensory modalities significant as normal cognitive development depends on an accurate representation our environment. The hearing range from deafness to hypersensitivity abnormal sound-evoked brainstem reflexes evoked...
We describe neurons in two nuclei of the superior olivary complex that display differential sensitivities to sound duration. Single units medial nucleus trapezoid body (MNTB) and paraolivary (SPON) anesthetized rats were studied. MNTB produced primary-like responses pure tones displayed a period suppressed spontaneous activity after stimulus offset. In contrast, SPON, which receive strong glycinergic input from MNTB, showed very little or no responded with short bursts action potentials...
The superior paraolivary nucleus (SPON) is a prominent periolivary cell group of the olivary complex. SPON neurons use gamma-aminobutyric acid (GABA) as their neurotransmitter and are contacted by large numbers glycinergic GABAergic punctate profiles, representing dense inhibitory innervation from medial trapezoid body (MNTB) collaterals axons, respectively. have low rates spontaneous activity, respond preferentially to offset pure tones, phase-lock amplitude-modulated tones. To determine...