A5023772513- Human Health and Disease
- Thermoregulation and physiological responses
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Heart Rate Variability and Autonomic Control
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Biochemical effects in animals
- Bone and Dental Protein Studies
- Medical and Biological Sciences
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Immunotoxicology and immune responses
- Electrolyte and hormonal disorders
- Digital Holography and Microscopy
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- Diabetes Management and Research
- Global Health and Surgery
- Biomarkers in Disease Mechanisms
- Scientific Research and Studies
- Pancreatic function and diabetes
- Thermal Regulation in Medicine
- Freezing and Crystallization Processes
- Thallium and Germanium Studies
Sumy State University
2013-2025
Abstract Breast cancer (BC) continues to be a significant global challenge due drug resistance and severe side effects. The increasing prevalence is alarming, requiring new therapeutic approaches address these challenges. At this point, Extracellular vesicles (EVs), specifically small endosome-released nanometer-sized EVs (SEVs) or exosomes, have been explored by literature as potential theranostics. Therefore, review aims highlight the of exosomes in BC, focusing on their advantages...
Abstract. The number of patients with diabetes increases annually. Modern forecasts predict that will be the seventh leading cause death in 2030. Despite many significant advances research and use new modern treatments, disease is still progressing, it necessary to continue study effects on human systems organs: kidney myocardium.
 Methods. A total 24 rats reproductive age (6 months old) were involved this experimental study. Experimental injected alloxan intraperitoneally once at a...
Background: Chronic water overload leads to a remodeling of the internal organs, in particular heart. The reaction organism influence damaging factors varies depending on age. Therefore, complex treatment diseases, which results positive balance, requires prescription cardioprotectors.The aim our study was determination morphological changes heart rats different age under hypoosomolar hyperhydration and an attempt correct detected by means meldonium.
 Material Method:The experiment...
Analysis of the results experimental studies on skeletal bone structure disorders in setting hyperglycemia discovered a lack information peculiarities remodeling process and structural functional changes osteogenic cells long tubular bones depending duration diabetes mellitus. Objective. Therefore, aim our study was to determine effect mature rats. Methods Materials. used femurs: 1) transmission electron microscopy, 2) immunohistochemical. In osteoblasts, special attention paid integrity...
Background. Heavy metal salts adversely affect the health of population and cause development pathology individual organs systems body. The adrenal glands occupy one key places in regulation maintenance basic functions Objective. study morphological adaptive rearrangements structural components cortex adult mature males under conditions prolonged exposure to heavy non-hormonal correction by vitamin E remains a relevant under-studied topic. Methods. experiment was conducted on 24 white male...
Background. The existence of several models the myolamellar structure ventricular myocardium, which currently has a number contradictory provisions, reflects need for reasonable integration results different methods. Under these circumstances, study those ontogenetic mechanisms that are responsible formation and development architecture myocardium is great interest. purpose to determine transformations embryonic chicken heart ensure myocardium. Methods. work examined embryos Cobb500 cross...
Aim: The research paper presents the characteristic of cytoarchitectonics thymus intact white mature male laboratory rats. Topicality study is due to need clarify data on contribution each type cells in formation its structure. aim was determine specifics localization and ultramicroscopic structure Wistar Material Methods: conducted using histological methods 10 rats, weighing 130-150 g. Semi-thin (0.5-1 μm) ultrathin (0.05-0.2 sections were made a microtome UMTP-4 (Ukraine), which stained...
Background. The constant composition of the water-electrolyte balance is a necessary condition for vital activity organism. Violations homeostasis cause significant changes in all systems body, including endocrine. Objective. purpose work to study morphological and morphometric alterations vascular bed adenohypophysis sexually mature male rats under conditions experimental secondary-depletion extracellular dehydration. Methods. experiment was conducted on 12 white, weighing 250-300 g aged...
The salts of heavy metals negatively affect the health population and cause development pathology individual organs systems body. Adrenal hormones are one key places in regulating maintaining basic functions aim study — morphological rearrangements structural components adrenal cortex sexually mature male rats under conditions prolonged exposure to combination metal remains relevant insufficiently studied. experiment was conducted on 12 animals weighing 250–300 g, aged 7–8 months. Animals...
The aim: To evaluate morphological changes in long tubular bones of mature rats under the influence experimental hyperglycemia. Materials and methods: study was conducted on 140 nonlinear white male divided into two groups. group included that were introduced a state hyperglycemia by single intraperitoneal injection an alloxan dihydrate solution at dose 150 mg / kg body weight 0.9% sodium chloride. control injected with similar volume chloride one time intraperitoneally. animals taken out...
У статті опрацьовано та докладно розглянуто сучасний літературний матеріал стосовно ролі води в організмі дегідратаційних порушень водного балансу, а саме: детально описані позаклітинний (ізо- гіпоосмолярний), внутрішньоклітинний (гіперосмолярний) загальний (як наслідок першого і другого варіантів) види зневоднення.
We use the combination of digital holographic interference and electron microscopy methods for study 3D morphology blood erythrocytes rats that took water with high concentrations heavy metal salts a month. The obtained results show essential morphological changes in experimental group animals, increase quantity transformed degenerative erythrocytes, decrease average diameter normal transformations shapes direction sphericity coefficients increase.