A5090764719- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Dermatologic Treatments and Research
- Data Visualization and Analytics
- Cinema and Media Studies
- Data Mining Algorithms and Applications
- Single-cell and spatial transcriptomics
- Customer churn and segmentation
- Body Contouring and Surgery
- Genital Health and Disease
- Traffic Prediction and Management Techniques
- Diabetes Management and Research
- Neural dynamics and brain function
- Laser Applications in Dentistry and Medicine
- Digital Media Forensic Detection
- Pancreatic function and diabetes
- Facial Nerve Paralysis Treatment and Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Advanced Steganography and Watermarking Techniques
- Herpesvirus Infections and Treatments
- Human Pose and Action Recognition
- Acne and Rosacea Treatments and Effects
Hornsby Ku-ring-gai Hospital
2024
St Vincent's Clinic
2021-2022
UNSW Sydney
2008-2022
Vinayaka Missions University
2022
Prince of Wales Hospital
2008
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to production (KYN), neuroprotectants, kynurenic acid (KYNA) and picolinic (PIC), excitotoxin, quinolinic (QUIN) essential pyridine nucleotide, nicotinamide adenine dinucleotide (NAD+). enzymes indoleamine 2,3-dioxygenase-1 (IDO-1), 2,3-dioxygenase-2 (IDO-2) tryptophan 2,3-dioxygenase (TDO-2) initiate first step KP. IDO-1 TDO-2 induction in tumors are crucial mechanisms implicated play pivotal roles...
The kynurenine pathway is a fundamental mechanism of immunosuppression and peripheral tolerance. It increasingly recognized as playing major role in the pathogenesis wide variety inflammatory, neurodegenerative malignant disorders. However, temporal dynamics activation metabolite production human immune cells currently unknown. Here we report novel use flow cytometry, combined with ultra high-performance liquid chromatography gas chromatography-mass spectrometry, to sensitively quantify...
During inflammation, the kynurenine pathway (KP) metabolises essential amino acid tryptophan (TRP) potentially contributing to excitotoxicity via release of quinolinic (QUIN) and 3-hydroxykynurenine (3HK). Despite importance in development secondary brain damage, investigations on KP TBI are scarce. In this study, we comprehensively characterised changes activation by measuring numerous metabolites cerebrospinal fluid (CSF) from patients assessing expression key enzymes tissue victims. Acute...
The excitotoxin quinolinic acid, a by-product of the kynurenine pathway, is known to be involved in several neurological diseases including multiple sclerosis (MS). Quinolinic acid levels are elevated experimental autoimmune encephalomyelitis rodents, widely used animal model MS. Our group has also found pathophysiological concentrations MS patients. This led us investigate effect on oligodendrocytes; main cell type targeted by response We have examined pathway (KP) profile two...
Abstract Background Multiple sclerosis (MS) is a chronic immune-mediated disorder of the central nervous system characterized by demyelination, neuroinflammation, and neurodegeneration. Activation kynurenine pathway (KP) results from acute neuroinflammation leading to both immune suppression neurotoxicity. However, exact effects KP metabolites changes in neurodegenerative diseases over time are not fully understood. Studies, including those MS models, have reported that short-term activation...
The kynurenine pathway (KP) is a major degradative of tryptophan ultimately leading to the production nicotinamide adenine dinucleotide (NAD + ) and also one regulatory mechanisms immune response. KP known be involved in several neuroinflammatory disorders including Alzheimer's disease, amyotrophic lateral sclerosis, AIDS dementia complex, Parkinson's schizophrenia, Huntington's disease brain tumours. However, remains relatively new topic for field multiple sclerosis (MS). Over last 2–3...
Abstract Longitudinal studies that continuously generate data enable the capture of temporal variations in experimentally observed parameters, facilitating interpretation results a time-aware manner. We propose IL-VIS (incrementally learned visualizer), new machine learning pipeline incrementally learns and visualizes progression trajectory representing longitudinal changes studies. At each sampling time point an experiment, generates snapshot process on thus far, feature is beyond reach...
The essential amino acid, tryptophan, is predominantly metabolised through the kynurenine pathway (KP) to generate kynurenine, an aryl-hydrocarbon receptor (AhR) pro-ligand that exerts its effects in a ligand-dependent manner. Interaction between and AhR effector mechanism of immunosuppression. We previously found KP involved multiple sclerosis (MS) disease progression. postulated activation by might be neuroprotective encouraging differentiation Tregs. In this study, we assess both...
Background The objective of the present study was to describe morphological and clinical patterns paederus dermatitis (PD). Methodology This retrospective case series conducted in outpatient department Department Dermatology, Srinivasan Medical College Hospital, Trichy, Tamil Nadu, between June 2023 August among patients with a diagnosis PD. Results included total 10 patients. mean (SD) age 19.4 (1.9) years. More than half (60.0%) were males. Of included, four (40.0%) from rural areas, three...
Introduction Acne scars can play havoc with the social functioning of patient leading to severe depression reduced quality life. Fractional CO 2 laser provides a fine balance between undesirable side effects ablative lasers and limited efficacy nonablative lasers. Objective The present study was conducted evaluate safety fractional in treatment acne scars. Patients methods performed on 30 patients atrophic scar by different protocols depending type its depth. Results were assessed based...
Background: Over the past two years, there has been an alarming rise of syphilis in many developed and developing countries, owing to increase HIV/AIDS, changes sex practices, drug abuse so on. Methods: A total 10 patients were diagnosed as secondary Venereology Out Patient Department our hospital over a short period 4 months from July 2021 October 2021. Demographic details, presenting complaints, duration skin lesions, sexual history, treatment history any other STIs, abuse, blood...
Acute zoster pain and post-herpetic neuralgia are the most common nagging complications after herpes zoster. Sometimes, temporary paresis of segmental nerves follows resulting in or muscle Here, we report a case manifesting as abdominal pseudohernia. A 55-year-old male presented to dermatology outpatient department with complaints intense pain, burning sensation, paresthesia over left side his abdomen. He had history same site 2 weeks back. Then, he noticed swelling abdomen, associated...
ABSTRACT Longitudinal studies that continuously generate data enable the capture of temporal variations in experimentally observed parameters, facilitating interpretation results a time-aware manner. We propose IL-VIS (Incrementally Learned Visualizer), new machine learning pipeline incrementally learns and visualizes progression trajectory representing longitudinal changes studies. At each sampling time point an experiment, generates snapshot process on thus far, feature is beyond reach...