A5038716570- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Enzyme function and inhibition
- Pharmacogenetics and Drug Metabolism
- Synthesis and Biological Evaluation
- Prostate Cancer Treatment and Research
- Catalytic Cross-Coupling Reactions
- Cholinesterase and Neurodegenerative Diseases
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Reaction Mechanisms
- Colorectal Cancer Treatments and Studies
- Hormonal and reproductive studies
- Fungal Plant Pathogen Control
- Cancer Mechanisms and Therapy
- Synthesis and Reactions of Organic Compounds
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Acute Lymphoblastic Leukemia research
- Chemical synthesis and pharmacological studies
- Microwave-Assisted Synthesis and Applications
- Synthesis and bioactivity of alkaloids
Sivas Cumhuriyet Üniversitesi
2017-2024
Ege University
2008-2012
Pharmaceutical Biotechnology (Czechia)
2010
University of Eastern Finland
2008
The aim of this study was to evaluate biologically active novel molecules having potentials be drugs by their antitumor properties and activities apoptotic caspase topoisomerase. Following syntheses eight bis(α-aminoalkyl)phosphinic acid derivatives (4a-h) as a result array reactions, compounds were evaluated cytotoxic effects in vitro on human breast cancer (MCF-7) normal endothelial (HUVEC) cell lines. All phosphinic effective for cytotoxicity both MCF-7 HUVEC lines, while 4c, 4e, 4f found...
Chalcones (1,3-diaryl-2-propen-1-ones) are alpha, beta-unsaturated ketones with cytotoxic and anticancer properties. Several reports have shown that compounds properties may also interfere DNA topoisomerase functions. Five derivatives of 4'-hydroxychalcones were examined for cytotoxicity against transformed human T (Jurkat) cells as well plasmid supercoil relaxation experiments using mammalian I. The 3-phenyl-1-(4'-hydroxyphenyl)-2-propen-1-one (I),...
1a A number of studies reported Mannich bases to manifest antimicrobial, cytotoxic, anticancer, anti-inflammatory, and anticonvulsant activities. considerable therapeutically important cytotoxic compounds are active on DNA topoisomerases that regulate the topology. In present study we evaluated biological activity mono- bases, 1-aryl-3-phenethylamino-1-propanone hydrochlorides (- 10a ), semicyclic 3-aroyl-4-aryl-1-phenethyl-4-piperidinols ( 1b - 9b synthesized in our laboratory. We employed...
Cytochrome P450 (CYP) is a heme-containing enzyme superfamily metabolizing wide variety of xenobiotics, including drugs and carcinogens. The majority CYP genes are expressed in the liver, however, some isoforms also reported for number extra hepatic tissues. We analyzed P450-2A6, -3A5 -4B1 mRNAs using realtime reverse-transcriptase polymerase chain reaction (RT-PCR) total 21 homogenized prostate tissues with or without malignancy. detected consistent expression CYP2A6 CYP3A5 all, CYP4B1...
Cancer is a disease that occurs as result of abnormal or uncontrolled growth cells due to DNA damage, among many other causes. Certain cancer treatments aim increase the excess breaks such an extent they cannot escape from general mechanism cell checkpoints, leading apoptosis mutant cells. In this study, one Sarco-endoplasmic reticulum Ca2+ATPase (SERCA2a) inhibitors, Istaroxime, was investigated. There has been very limited number articles so far reporting Istaroxime's anticancer activity;...
The discovery of many drugs in recent years provides a definitive solution the treatment various diseases, but today, despite effective anticancer drugs, there are types cancer that have limitations and still not completely curable. Since most these due to cells gaining resistance or compounds only being certain cells, search for more also is inevitable. Cabozantinib medical use as highly drug cancer, such medullary thyroid kidney cancer. properties compound attracted attention years,...