A5027327953- Legionella and Acanthamoeba research
- Bacterial biofilms and quorum sensing
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Antimicrobial agents and applications
- biodegradable polymer synthesis and properties
- Polymer Nanocomposites and Properties
- Medical and Biological Ozone Research
- Synthesis and properties of polymers
- Dendrimers and Hyperbranched Polymers
- Polymer Nanocomposite Synthesis and Irradiation
- RNA Interference and Gene Delivery
- Synthesis of Tetrazole Derivatives
- Synthesis and biological activity
- Thermal and Kinetic Analysis
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Chemistry and Chemical Engineering
- Oral health in cancer treatment
- Drug Solubulity and Delivery Systems
- Viral Infections and Vectors
- Electrospun Nanofibers in Biomedical Applications
- Enzyme Catalysis and Immobilization
- Carbon and Quantum Dots Applications
- Ocular Infections and Treatments
Sivas Cumhuriyet Üniversitesi
2012-2025
Istanbul University
2011
Although there have been a number of studies on the pathogenesis Crimean-Congo hemorrhagic fever (CCHF) recently, knowledge this topic is still insufficient. This study aims to reveal kinetics serum CCHF virus (CCHFV) titers, levels anti-CCHFV immunoglobulin (Ig)G, tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, and interferon (IFN)-γ in patients.In total, 31 cases (11 fatal) were studied. Serum samples obtained daily from all patients time admission continued for 7-day...
Studies aimed at increasing the efficacy of chemotherapeutic drugs and reducing or completely eliminating their side effects are frequently encountered. In our study, we considered methotrexate (MTX), which is in category anticarcinogenic anti-inflammatory drugs, gemcitabine (GEM), used treatment breast, testicular, ovarian, etc. cancers. GEM, cancers, was covalently bonded to maleic anhydride vinyl acetate (MAVA) copolymer, new polymer–drug conjugates (MAVA–MTX MAVA–GEM) were obtained...
Abstract Poly[(maleic anhydride)‐ co ‐(vinyl acetate)] (MAVA) copolymer was synthesized by free radical polymerization reaction, in methyl ethyl ketone at 80 °C, using benzoyl peroxide as the initiator. The then modified with a biomolecule, noradrenaline (NA). modification reaction performed 70 °C dimethylformamide containing triethylamine catalyst. polymer named MAVA/NA. Structural characterization of and product carried out Fourier transform infrared (FTIR) 1 H NMR 13 C spectroscopy. FTIR,...
Abstract In recent years, polymeric drug conjugates, nanoparticles, nanocapsules, liposomes, micelles, dendrimers, and nanogels have been gained a great attention. Organically modified layered nanoclays become an attractive hybrid biomaterial due to their wide range of uses, which can be designed with desired properties in variety applications from industry medicine. Functional water‐soluble poly(maleic anhydride‐ alt ‐acrylic acid) [poly(MA‐ ‐AA)], synthesized our previous study, was chosen...
Poly(maleic anhydride-co-styrene) (MAST) was synthesized by a free-radical polymerization reaction. A bioactive molecule, procainamide hydrochloride (PH), then conjugated to MAST. The conjugation product named as MAST/PH. Structural characterization of MAST and MAST/PH carried out Fourier Transform Infrared Nuclear Magnetic Resonance spectroscopy. Their molecular weights were determined size-exclusion chromatography. mechanism suggested for the results cytotoxicity assay, employing mouse...
Abstract Maleic anhydride copolymer was modified with another biologically active agent, noradrenaline (NA), using both chemical and enzymatic methods. The modification synthesized products were named as follows: modification, MASTNAc; MASTNAe; enzymatically MASTNA from individual monomers, MASTNAem. Chemical reactions performed at 70°C 38°C, respectively. In the azobisisobutyronitrile used initiator. reactions, an extracellular extract, including enzyme peroxidase‐like activity, used. All...
Poly (maleic anhydride-co-vinyl acetate) (MAVA) copolymer was synthesized by free-radical-polymerization reaction in methyl ethyl ketone (MEK) at 80 ºC using benzoyl-peroxide (BPO) as the radical-initiator.MAVA then modified with anti-leukemic chemotherapy-agent cytosine β-Darabinofuranoside hydrochloride (CF).Modification performed 70 o C dimethylformamide (DMF) containing triethylamine (Et 3 N) catalyst.Structural characterization of and copolymer/drug couple (MAVA/CF) carried out Fourier...
Abstract 1,2‐Phenylenediamine ( o ‐PDA) is a well‐known fluorescent dye that enables the decoration of next‐generation chemotherapeutics. A novel ‐PDA‐functionalized maleic anhydride‐allyl phenyl ether (poly(MA‐ alt ‐APE)/ ‐PDA conjugate) was successfully synthesized according to Ringsdorf model, which starting point for macromolecular prodrugs. Functional polymeric‐carriers were prepared by free‐radical polymerization in butyl acetate with azobisisobutyronitrile (AIBN) radical‐initiator at...
Amac. Poli(maleik anhidrit-ko-vinil asetat) kopolimerinin (MAVA) antitumoral aktiviteye sahip oldugu bilinmektedir ve ayni zamanda cesitli biyolojik aktivitelere Corresponding Author: Dr. Gulderen Karakus, CUTFAM, Cumhuriyet Universitesi Tip Fakultesi, TR-58140 Sivas. Email: gulderenkarakus@gmail.com sahiptir. MAVA’nin amobisidal etkisi daha once incelenmemistir. Yontem. Bu arastirmada ilk kez aktivitesi Acanthamoeba trofozoit kistleri uzerinde incelendi. Hucre canliligini belirlemek icin...
Maleik anhidrit (MA), C
The aim of this study was to investigate the effect radiation doses very close human dose for oral cancers on mechanical, chemical and physical properties poly methyl-methacrylate (PMMA).PMMA samples were divided into four different groups: no irradiated group, 25-Gy 50-Gy group 75-Gy group. Each contained nine samples. After 24 h, a three-point loading test applied each PMMA groups. transverse strength elastic modulus calculated using results. results analyzed statistically by one-way...
Poly (maleic anhydride-co-vinyl acetate) (MAVA) copolymer was synthesized by free-radical copolymerization in methyl ethyl ketone (MEK) at 80oC, using benzoyl peroxide (BPO) as the initiator. The radical chain confirmed Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (1H-NMR) spectra. Copolymer surface morphology visualized scanning electron microscopy (SEM). After these characterization studies, amoebicidal effect of MAVA investigated on E.histolytica trophozoites differing...
Cancer is a disease that occurs as result of abnormal or uncontrolled growth cells due to DNA damage, among many other causes. Certain cancer treatments aim increase the excess breaks such an extent they cannot escape from general mechanism cell checkpoints, leading apoptosis mutant cells. In this study, one Sarco-endoplasmic reticulum Ca2+ATPase (SERCA2a) inhibitors, Istaroxime, was investigated. There has been very limited number articles so far reporting Istaroxime's anticancer activity;...
In recent years, polymeric systems are selected as biomaterials because of their desired biocompatible properties and easy design/preparation a number different structures with lower toxicity good solubility. Nontoxic drug carrier, maleic anhydride-co-vinyl acetate copolymer (MAVA), was prepared via free-radical chain polymerization at 80±0.1 ºC. MEK (methyl ethyl ketone) BPO (benzoyl peroxide) were used the organic medium radical initiator, respectively. Copolymer conjugated broad-spectrum...
Aim: Studies to increase the efficacy of chemotherapeutic drugs and reduce or completely eliminate side effects are frequently encountered. In this study, we aimed anticancer antimicrobial new conjugate by using newly obtained polymer-drug (MAVA-CYT) Cytarabine (CYT) drug used in treatment leukemia. Method: The conjugation reaction was carried out at 70° C dimethylformamide under triethylamine catalysis. Structural characterization copolymer performed. Anticancer activity were determined XTT...
This study includes the design, synthesis and characterization of 1,2-phenylenediamine (o-PDA) functionalized maleic anhydride (MA)-vinyl acetate (VA) copolymer-based conjugate to develop a new formulation. The molecule is fluorescent dye that allows designing chemotherapeutic polymeric molecules. Poly(maleic anhydride-alt-vinyl acetate) [Poly(MA-alt-VA)] was obtained via charge transfer complex (CTC) radical polymerization presence methyl ethyl ketone (MEK), utilizing benzoyl peroxide (BPO)...
rHintergrund: Die Verminderung der biliären Ausscheidung von Antibiotika steht im Verhältnis zu einem intrabiliären Druckanstieg. Ziel dieser Studie war es, den Effekt einer Gallengangsobstruktion auf die biliäre Meropenem untersuchen. Material und Methoden: In wurden 110 Wistar-Albinoratten eingesetzt, welche in 11 Gruppen mit jeweils 10 Ratten unterteilt wurden. A1, B1, C1, D1, E1 F wurde Gallengang 7 Tage lang ligiert. An Tieren Kontrollgruppen (A2, B2, C2, D2 E2) eine Scheinoperation...