A5059648758- Eicosanoids and Hypertension Pharmacology
- Pharmaceutical Practices and Patient Outcomes
- Nitric Oxide and Endothelin Effects
- Peroxisome Proliferator-Activated Receptors
- Pharmacology and Obesity Treatment
- Health Literacy and Information Accessibility
- Health Systems, Economic Evaluations, Quality of Life
- Innovations in Medical Education
- Adipose Tissue and Metabolism
- Health and Medical Education
- Hormonal Regulation and Hypertension
- Biomedical and Engineering Education
- Phytochemicals and Antioxidant Activities
- Patient-Provider Communication in Healthcare
- Antioxidant Activity and Oxidative Stress
- Health Education and Validation
- Multiple Sclerosis Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Diabetes Treatment and Management
- Cytokine Signaling Pathways and Interactions
- Antibiotic Use and Resistance
- Stress and Burnout Research
- Social Media in Health Education
- Migraine and Headache Studies
- Mobile Health and mHealth Applications
Universidad de Granada
2013-2025
Hospital General Universitario Gregorio Marañón
2016
Universidad Complutense de Madrid
2016
Hospital Universitario Virgen de las Nieves
2014
Centro de Investigación Biomédica en Red
2014
Hospital Clínico San Carlos
2014
Cambridge University Press
2011
New York University Press
2011
The cardiovascular effects of probiotics Lactobacillus fermentum CECT5716 (LC40), or L. coryniformis CECT5711 (K8) plus gasseri CECT5714 (LC9) (1:1) in spontaneously hypertensive rats (SHR) were evaluated.Ten Wistar Kyoto (WKY) and 30 SHR randomly assigned to four groups (n = 10): a control WKY group, groups, an group treated with LC40, K8/LC9 for 5 weeks (at dose 3.3 × 10(10) colony-forming units/day drinking water). Long-term administration reduced systolic blood pressure. consumption...
Hydroxychloroquine has been shown to be efficacious in the treatment of autoimmune diseases, including systemic lupus erythematosus. Hydroxychloroquine-treated patients showed a lower incidence thromboembolic disease. Endothelial dysfunction, earliest indicator development cardiovascular disease, is present lupus. Whether hydroxychloroquine improves endothelial function not clear. The aim this study was analyze effects on hypertension, and renal injury female mouse model NZBWF1 (lupus)...
Abstract Scope: The dietary flavonoid quercetin exerts protective cardiovascular effects. Because is rapidly metabolized into less active or inactive glucuronidated metabolites and the plasma concentrations of free are very low, a huge amount scientific data generated along decades with unconjugated compounds in vitro has been questioned. We aimed to determine whether can deconjugate situ deconjugation leads biological effect. Methods results: Quercetin quercetin‐3‐ O ‐glucuronide (Q3GA)...
Red wine polyphenols (RWPs) have been reported to prevent hypertension and endothelial dysfunction. Several individual RWPs exert estrogenic effects. We analyzed the possible in vivo protective effects on blood pressure function of female spontaneously hypertensive rats (SHR) its relationship with ovarian function. (40 mg/kg by gavage) were orally administered for 5 weeks. Ovariectomized showed both increased isoprostaglandin F 2α excretion aortic superoxide production reduced relaxant...
Activation of nuclear hormone receptor peroxisome proliferator-activated β/δ (PPARβ) has been shown to improve insulin resistance and plasma high-density lipoprotein levels, but nothing is known about its effects in genetic hypertension. We studied whether the PPARβ agonist GW0742 might exert antihypertensive spontaneously hypertensive rats (SHRs). The were divided into 4 groups, Wistar Kyoto rat-control, rat-treated (GW0742, 5 mg · kg(-1) day(-1) by oral gavage), SHR-control, SHR-treated,...
The present study analysed the effects of flavanol ( − )-epicatechin in rats after chronic inhibition NO synthesis with N G -nitro- l -arginine methyl ester -NAME), at doses equivalent to those achieved studies involving human subjects. Wistar were randomly divided into four groups: (1) control-vehicle, (2) -NAME, (3) -NAME-epicatechin 2 -NAME-Epi 2) and (4) 10 10). Rats daily given by oral administration for 4 weeks: vehicle, or mg/kg. Animals -NAME groups received 75 mg/100 ml...
Peroxisome proliferator-activated receptor β/δ (PPAR-β) is a ligand-activated transcription factor belonging to the nuclear hormone superfamily that regulates of many target genes. More recently, acute, nongenomic effects PPAR-β agonists have also been described. In present study, we hypothesized might exert acute on vascular tone. Here, report structurally unrelated ligands [4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid (L-165041) and...
We tested whether the administration procedure of quercetin affects its metabolite profile and antihypertensive activity. Spontaneously hypertensive rats (SHR) were randomly assigned to four experimental treatments: (1) 1 mL 1% methylcellulose by oral gavage 2% DMSO i.p. (control group); (2) 10 mg kg⁻¹ once daily i.p.; (3) divided in two doses (5 + 5 at 12 h intervals) (4) injection. Rats treated for weeks. Single dose doses, a long-term treatment equally efficient, both restoring impaired...
RWPs (red wine polyphenols) exert antihypertensive effects and improve endothelial function by reducing the plasma levels of ET-1 (endothelin-1) subsequent vascular production O2•− (superoxide anion). Our present study was designed to evaluate whether act directly in wall improving dysfunction induced analyse compounds responsible for these protective effects. We incubated rat isolated aortic rings presence or absence (10 nM) (10−4 10−2 g/l) catechin (0.2 μM), epicatechin μM) resveratrol...
PPARβ enhances insulin sensitivity in adipocytes and skeletal muscle cells, but its effects on signalling endothelial cells are not known. We analysed the of PPARβ/δ (PPARβ) agonists, GW0742 L165041, impaired induced by high glucose HUVECs aortic mesenteric arteries from diabetic rats.Insulin-stimulated NO production, Akt-Ser(473) eNOS-Ser(1177) phosphorylation, reactive oxygen species (ROS) production were studied incubated low- or high-glucose medium. Insulin-stimulated relaxations protein...
Endothelial dysfunction plays a key role in obesity-induced risk of cardiovascular disease. The aim the present study was to analyze effect chronic peroxisome proliferator-activated receptor (PPAR)β/δ agonist GW0742 treatment on endothelial function obese mice fed high-fat diet (HFD).Five-week-old male were allocated one following groups: control, control-treated (GW0742, 3 mg/kg per day, by oral gavage), HFD, HFD + GW0742, GSK0660 (1 mg/kg/day, intraperitoneal) or HFD-GW0742-GSK0660 and...
We analysed the chronic effects of peroxisome proliferator-activated receptor β/δ (PPAR-β) agonist GW0742 on renin-independent hypertension induced by deoxycorticosterone acetate (DOCA)-salt. Rats were treated for 5 weeks with: control-vehicle, control-GW0742 (5 or 20 mg kg−1 day−1), DOCA-vehicle, DOCA-GW0742 DOCA-GSK0660 (1 and DOCA-GSK0660-GW0742. receiving DOCA-vehicle showed increased systolic blood pressure, left ventricular kidney weight indices, endothelin-1 (ET-1), malondialdehyde...
Activation of peroxisome proliferator–activated receptor-<i>β</i>/<i>δ</i> (PPAR<i>β</i>) lowers blood pressure in genetic and mineralocorticoid-induced hypertension. Regulator G-protein-coupled receptor signaling 5 (RGS5) protein, which interferes angiotensin II (AngII) signaling, is a target gene to PPAR<i>β</i>. The aim the present study was examine whether PPAR<i>β</i> activation resistance arteries brain tissues prevents elevated AngII-induced hypertension evaluate role RGS5 this...
Effective health communication will not be possible if the messages directed to patients do adapt their literacy skills. In this sense, Patient Information Leaflets (PILs) are understood properly, they fulfill purpose. Secondary education aims develop students' fundamental skills, including reading comprehension, which should align with future patients. This study assesses comprehension of commonly used PILs among secondary students. An observational cross-sectional involved 590 Spanish...
Objectives To evaluate an implementation programme of a community pharmacy medication review with follow-up (MRF) service using hybrid effectiveness-implementation study design, and to compare the clinical humanistic outcomes those in previously conducted cluster randomised controlled trial (cRCT). Setting Community pharmacies Spain. Participants 135 222 pharmacists providing MRF polymedicated patients aged 65 or over. Intervention The intervention was for service. A national level group...