A5006553647- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Genetic Associations and Epidemiology
- Heavy Metal Exposure and Toxicity
- vaccines and immunoinformatics approaches
- Blood disorders and treatments
- Genomic variations and chromosomal abnormalities
- Bioinformatics and Genomic Networks
- Schizophrenia research and treatment
- Genetics and Neurodevelopmental Disorders
- Genetic factors in colorectal cancer
- Alcohol Consumption and Health Effects
- Cancer, Hypoxia, and Metabolism
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Selenium in Biological Systems
- SARS-CoV-2 and COVID-19 Research
- Cancer, Lipids, and Metabolism
- Gout, Hyperuricemia, Uric Acid
- Birth, Development, and Health
- Genomics and Rare Diseases
- Ovarian function and disorders
- Advanced Biosensing Techniques and Applications
- Arsenic contamination and mitigation
- Autism Spectrum Disorder Research
Shanghai Jiao Tong University
2016-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2023
Bridge University
2020
Ministry of Public Security of the People's Republic of China
2018
The spread of the latest SARS-CoV-2 variant Omicron is particularly concerning because large number mutations present in its genome and lack knowledge about how these would affect current vaccines treatments. Here, by performing phylogenetic analysis using spike (S) protein sequence, we found that S presented longest evolutionary distance relation to other variants. We predicted structures S, M, N proteins AlphaFold2 investigated have affected parts, S1 NTD RBD, detail. many amino acids on...
Abstract Inspired by the antibacterial agents, such as ethylene oxide, anacardic acid, and salicylic oxygen‐terminated carbon bonds may take major responsibility in properties, a layer of is fabricated on nanodiamond an immobilized coating for investigation activity. The results demonstrate comparable activities (NDC) against two kinds probe bacteria, Gram‐negative Escherichia coli Gram‐positive Staphylococcus aureus , annealing method proper improvement performance NDC. concentration bonds,...
Numerous studies have shown that Astragalus polysaccharide (APS) has strong antioxidant effects and high practical value for preserving semen at low temperatures in vitro. However, to date, little attention been paid the precise mechanism of APS sperm preservation 4 °C. Thus, gain further insight into protective APS, present study was performed assess changes quality parameters, capacity, ATP content, protein phosphorylation levels. Here, we demonstrated supplementation with could...
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has evolved many variants with stronger infectivity and immune evasion than the original strain, including Alpha, Beta, Gamma, Delta, Epsilon, Kappa, Iota, Lambda, 21H strains. Amino acid mutations are enriched in spike protein of SARS-CoV-2, which plays a crucial role cell infection. However, impact these on structure function is unclear. Understanding pathophysiology pandemic features requires knowledge structures. Here, we...
A number of emerging studies suggest that pathogenic microorganisms in semen may cause a decline the reproductive potential spermatozoa, and bacterial diversity profile ejaculated boar different seasons are currently unknown. To explore composition changes from winter summer, underlying mechanism sperm quality fertility capacity 120 samples were examined for communities using genomic sequencing technology, associations between microbial investigated. The results showed Proteobacteria...
Gout is a disease that manifests itself after decades of following high-purine diet, with excessive alcohol consumption assumed to be one the main contributors development disease. This study performs Mendelian randomization (MR) analysis determine whether causally affects risk developing both hyperuricemia and gout. The results indicate genetically predicted drinks consumed per week have no causal effect on neither gout (p = 0.35), nor serum uric acid levels 0.73). For MR in other...
In July 2022, a new virus called Langya (LayV) was discovered in China patients who had fever. This is type of Henipavirus (HNV) and considered potential threat as it could spread from animals to humans. It causes respiratory disease with symptoms including fever, coughing, fatigue closely linked two other henipaviruses that are known infect humans, namely Hendra Nipah viruses. These viruses may cause fatal illnesses. Investigators believe the LayV by shrews, have infected humans directly or...
Depending on the mammal species, use of seminal plasma during semen processing for cryopreservation has been found to have both beneficial and detrimental effects. This study was designed determine effects concentration motility, sperm movement characteristics, acrosome membrane integrity chilled canine spermatozoa. After pooling from seven dogs, samples each assay were preserved at 4oC 96h in extenders containing different concentrations (0, 25, 50, 75 100% (v/v) plasma). cold storage,...
Gout is of particularly high prevalence in the Māori and Pacific (Polynesian) populations Aotearoa New Zealand (NZ). Here, we investigated contribution common population-specific copy number variation (CNV) to gout NZ Polynesian population. Microarray-generated genome-wide genotype data from individuals with (n = 1196) without 1249) were analyzed. Comparator population groups 552 European ancestry 1962 Han Chinese ancestry. Levels circulating major histocompatibility complex (MHC) class I...
Background Schizophrenia is a chronic brain disorder. Previously, the Exome Sequencing Meta-analysis consortium identified 10 highest risk genes related to schizophrenia. This study aimed analyze relationship between by SCHEMA and schizophrenia in Chinese population. Methods A total of 225 variants were screened population 6836 using customized array. All annotated through Variant Effect Predictor tool, functional impacts missense assessed based on sorting intolerant from tolerant PolyPhen-2...
Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and has long been among top three cancers that cause most deaths worldwide. Therapeutic options for HCC are limited due to pronounced tumor heterogeneity. Thus, there a critical need study from systems point view discover effective therapeutic targets, such as through systematic disease perturbation in both regulation metabolism using unified model. Such integration makes sense it links one dominant physiological features...