A5059624839- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Nail Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Eosinophilic Disorders and Syndromes
- Skin Diseases and Diabetes
- Autoimmune and Inflammatory Disorders
- T-cell and B-cell Immunology
- RNA modifications and cancer
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Dermatological and Skeletal Disorders
- Urticaria and Related Conditions
- Genetic and rare skin diseases.
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer-related gene regulation
- Cutaneous Melanoma Detection and Management
- FOXO transcription factor regulation
- Epigenetics and DNA Methylation
- T-cell and Retrovirus Studies
- MicroRNA in disease regulation
- Fungal Infections and Studies
- Vasculitis and related conditions
- Sarcoidosis and Beryllium Toxicity Research
UConn Health
2015-2024
University of Connecticut
2014-2024
Medical University of South Carolina
2022-2023
American Academy of Dermatology
2016-2023
Washington University in St. Louis
2022-2023
The Ohio State University
2022-2023
Northwestern University
2023
Universidad Cristiana Autónoma de Nicaragua
2021
Case Western Reserve University
2008-2015
MetroHealth Medical Center
2015
Narrow-band (312 nm) ultraviolet B light (UVB) is a new form of therapy for psoriasis, but its mechanism action unknown. In bilateral comparison clinical study, daily exposure psoriatic plaques to broad-band UVB (290–320 or 312-nm depleted T cells from the epidermis and dermis lesions. However, was significantly more depleting in both tissue compartments. To characterize cell depletion, assays apoptosis were performed on derived UVB-irradiated skin vivo irradiated vitro with UVB. Apoptosis...
Abstract We showed previously that CCAAT/enhancer binding protein α (C/EBPα), a tissue-specific transcription factor, is candidate tumor suppressor in lung cancer. In the present study, we have performed transcriptional profiling study of C/EBPα target genes using an inducible cell line system. This led to identification hepatocyte nuclear factor 3β (HNF3β), known play role airway differentiation, as downstream C/EBPα. found down-regulation HNF3β expression large proportion cancer lines...
Abstract Purpose: The T cell repertoire in patients with advanced cutaneous lymphoma (CTCL) is significantly contracted despite the presence of relatively normal absolute numbers cells. We propose that many cells were being lost CTCL, remaining expanding clonally to fill compartment. T-cell receptor excision circles (TREC) form as a result initial gene rearrangement naïve Although they are stable, do not replicate and subsequently diluted expansion population Their concentration therefore...
PEComas are mesenchymal neoplasms composed of perivascular epithelioid cells (PEC) and include a spectrum tumors. malignant melanoma share common morphological, immunohistochemical, ultrastructural features, such as cell morphology melanocytic immunophenotype. Melanocytic markers commonly expressed in PEC tumors HMB-45, Melan-A/MART-1, tyrosinase, microphthalmia transcription factor (MITF), occasionally, S100. Given this morphological immunophenotypical overlap, the differential diagnosis...
Several types of cutaneous reactions have been reported to arise at the site herpes zoster (HZ) infection weeks years after acute disease. Among these, granulomatous are most frequently reported. In this study, we describe spectrum histopathologic findings HZ observed in 26 patients with lesions confined area previous eruption and compare them biopsy specimens taken from 25 HZ. All persistent whom history was available presented within 12 onset eruption. The frequent were interstitial...
Histologic differentiation of melanoma in situ (MIS) from solar keratosis on chronically sun‐damaged skin is challenging. The first‐line immunostain usually MART‐1/Melan‐A, which can exaggerate the epidermal melanocytes, causing a diagnostic pitfall for MIS. By comparing MART‐1 and SOX10 immunostaining, we scored percentage melanocytes per 2‐mm diameter fields pigmented actinic ( n = 16), lichenoid 7), junctional melanocytic nevus 6), with atypical proliferation 17) MIS 10). These cases...
Nonsexual acute genital ulceration (NAGU) is a rare vulvar skin condition typically affecting girls and young women, characterized by onset of singular or multiple painful vaginal ulcers. The etiology this ulcerative dermatosis has not been identified, although it associated with systemic infections. To our knowledge, the first report an association Lyme disease.A case woman early disseminated disease presenting NAGU reported. A thorough workup ruled out other causes ulceration, ulcers...
The prognosis of patients with stage IV cutaneous T-cell lymphoma (CTCL) is grim and therapeutic options are limited. Treatment advanced-stage CTCL aimed at suppressing the dominant clone, which typically present in skin, peripheral blood, lymph nodes.We detected expansion 1 clone expressing receptor V beta 14 blood a patient IVA CTCL. Before initiation combination therapy photopheresis low-dose interferon alpha, represented 84% total population. After successful therapy, this showed...
Extranodal nasal natural killer (NK)/T-cell lymphoma is a very rare characterized by strong association with Epstein-Barr virus infection, aggressive clinical behavior, and poor prognosis. The typical phenotype of neoplastic cells in this entity as follows: CD2+, CD56+, surface CD3−, cytoplasmic CD3ε+, cytotoxic granule-associated protein positive. CD30 expression, characteristic anaplastic large-cell lymphomas, not feature NK/T-cell lymphomas. We describe the case 42-year-old woman chronic...
Bullous pemphigoid (BP) is an autoimmune blistering disorder characterized by pruritic cutaneous blisters and erosive mucosal lesions. It predominantly affects elderly individuals rarely manifests in pediatric populations. Here, we describe a patient with recalcitrant BP successfully treated dupilumab. A 17-year-old girl no significant medical or family history reported blister on the left breast 2 months prior to presentation. She later began noticing vesicles inner legs. Her primary care...