A5060861164- Air Quality and Health Impacts
- Virus-based gene therapy research
- Bariatric Surgery and Outcomes
- Retinal Development and Disorders
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Asthma and respiratory diseases
- Opioid Use Disorder Treatment
- Neuroscience of respiration and sleep
- Musculoskeletal pain and rehabilitation
- Interprofessional Education and Collaboration
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Management and Opioid Use
- Herpesvirus Infections and Treatments
- Nursing Roles and Practices
- Infective Endocarditis Diagnosis and Management
- Innovations in Medical Education
- Cytomegalovirus and herpesvirus research
- Ultrasound in Clinical Applications
- Diversity and Career in Medicine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood disorders and treatments
- Sulfur Compounds in Biology
- Medical and Biological Ozone Research
Duke University
2025
Cleveland Clinic
2023
University of North Carolina at Chapel Hill
2016-2023
Lung Institute
2021
Many adeno-associated virus (AAV) serotypes efficiently transduce the retina when delivered to subretinal space but show limited success vitreous due inner limiting membrane (ILM). Subretinal delivery of AAV serotype 2 (AAV2) and its heparan sulfate (HS)-binding-deficient capsid led similar expression, indicating transduction outer occurred by HS-independent mechanisms. However, intravitreal HS-ablated recombinant AAV2 (rAAV2) a 300-fold decrease in compared AAV2. Fluorescence situ...
Abstract Understanding how exercise improves whole-body insulin sensitivity (Si) involves complex molecular signaling. This study examines skeletal muscle gene expression changes related to Si, considering sex differences, amount, and intensity identify pharmacologic targets mimicking benefits. Fifty-three participants from STRRIDE I II completed eight months of aerobic training. Gene was assessed via Affymetrix Illumina technologies, Si measured using intravenous glucose tolerance tests. A...
Abstract Although cord blood transplantation has significantly extended the lifespan of mucopolysaccharidosis type 1 (MPS1) patients, over 95% manifest cornea clouding with about 50% progressing to blindness. As corneal transplants are met high rejection rates in MPS1 children, there remains no treatment prevent blindness or restore vision children. Since is caused by mutations idua , which encodes alpha-L-iduronidase, a gene addition strategy and potentially reverse, MPS1-associated was...
Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) one consequence of ozone exposure, particularly for individuals underlying disease. Our data demonstrated that induced substantial ATP release from human airway epithelia in vitro and into the airways mice vivo served as potent inducer mast cell degranulation BHR, acting through P2X7 receptors cells. Both cell-deficient receptor-deficient (P2X7-/-)...
Abstract Background Types and correlates of pain medication agreement (PMA) violations in the primary care setting have not been analyzed. Methods A retrospective analysis was completed to examine patient characteristics PMA violations, a proxy for substance misuse, over 15-year period an outpatient General Medicine Pain Service within Division Clinical Epidemiology, Department Medicine, School University North Carolina at Chapel Hill. Patients who signed were managed chronic from 2002...
Poster: Glomerular Diseases: Clinicopathological Features and Outcomes in IgAN, Lupus Nephritis, Vasculitis