A5110576152- Infant Nutrition and Health
- Respiratory viral infections research
- Breastfeeding Practices and Influences
- Neonatal Respiratory Health Research
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Cardiac electrophysiology and arrhythmias
- Viral Infections and Immunology Research
- Atrial Fibrillation Management and Outcomes
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Forensic Toxicology and Drug Analysis
- Immunotherapy and Immune Responses
University Medical Center Utrecht
2016-2025
Wilhelmina Children's Hospital
2018
Heidelberg University
2016
University Hospital Heidelberg
2016
Antibodies in human milk protect infants against infections, but currently no assay is described that able to simultaneously measure all 9 antibody isotypes and subclasses immunoglobulins fluids, such as milk. Our cohort "Protecting Respiratory tract Infections through Milk Analysis" (PRIMA) focused on the relation between occurrence of respiratory infections during first year life concentration maternal antibodies breastfeeding. We developed successfully validated a multiplex nine plasma...
Respiratory syncytial virus (RSV) infections represent a major burden of disease in infants and are the second most prevalent cause death worldwide. Human milk immunoglobulins provide protection against RSV. However, many depend on processed bovine milk-based nutrition, which lacks intact immunoglobulins. We investigated potential antibodies to neutralize human RSV facilitate-cell immune activation. show cow's IgG (bIgG) Intravenous Immunoglobulin (IVIG) have similar neutralization capacity,...
Breastfeeding provides important immunological benefits to the neonate, but how different immunoactive components in breastmilk contribute immunity remains poorly understood. Here, we characterized human T cells using single-cell RNA-Seq and flow cytometry. Breastmilk contained predominantly memory cells, with expression of immune signaling genes, high proliferation, an effector Th1/cytotoxic profile cytokine production capacities. Elevated activation was balanced by enriched Treg population...
Abstract Background Many studies support the protective effect of breastfeeding on respiratory tract infections. Although infant formulas have been developed to provide adequate nutritional solutions, many components in human milk contributing protection newborns and aiding immune development still need be identified. In this paper we present methodology “Protecting against Respiratory lnfections through Milk Analysis” (PRIMA) cohort, which is an observational, prospective multi-centre birth...