ABSTRACT Aim On a population level in people aged ≥65 years old living New Zealand, the aim of this study is to quantify each individual's cumulative exposure anticholinergic and sedative medicines using Drug Burden Index (DBI) examine impact DBI on fall‐related hospitalisations, general practitioner (GP) visits, all‐cause mortality. Method The used data extracted from Pharmaceutical Claims Data Mart (2011), National Minimum set (2012), Births, Death Marriages (2012) GP Visits for patient...

Abstract Purpose Cost-avoidance studies of pharmacist interventions are common and often the first type study conducted by investigators to quantify economic impact clinical pharmacy services. The purpose this primer is provide guidance for conducting cost-avoidance pertaining practice. Summary represent a paradigm conceptually different from traditional pharmacoeconomic analysis. A reports on cost savings given intervention, where estimated based counterfactual scenario. Investigators need...

To examine the prevalence of potentially inappropriate medicines (PIMs) in older New Zealanders at a population level.De-identified prescription data for all individuals ≥65 years were obtained from Pharmaceutical Claims Data Mart 2011. International Classification Diseases-10-AM (version 6) codes used to extract diagnostic information National Minimum Datasets and PIMs identified using updated Beers 2012 criteria.40.9% people prescribed with approximately half dispensed ≥2 Exposure was...

Identifying potentially inappropriate medicines (PIMs) leading to adverse drug events may reduce the risk of morbidity and mortality in older people.The aim this study was examine relationship between exposure PIMs Fall-related hospitalisations (FRH) frequency primary care visits New Zealanders.Pharmaceutical collections (2011), diagnostic (2007-2011) (2012) information derived from National Minimum Datasets were used extract demographics, medication for 537,387 individuals aged ≥65 years....

It is recommended that therapeutic monitoring of vancomycin should be guided by 24-hour area under the curve concentration. This can done via Bayesian models in dose-optimization software. However, before these incorporated into clinical practice critically ill, their predictive performance needs to evaluated. study assesses for ill.Retrospective cohort study.Single-center ICU.Data were obtained all patients ICU between 1 January, and 31 May 2020, who received IV vancomycin. The three...

The lifetime use of combination antiretroviral therapy (cART) highlights the need to understand patterns and factors associated with adherence cART. In this cohort study using a 10% random sample dispensing claims data for eligible Australians, we identified 2042 people dispensed cART between January 2016 December 2017 (mean age 48.0 ± 12.0 years old, 88.6% male, 85.9% treatment experienced). We considered be adherent if proportion coverage days was ≥80% in 360 after their first observed...

Aims We investigated anticholinergic medicines use among older adults initiating dementia medicines. Methods used Pharmaceutical Benefits Scheme dispensing claims to identify patients who initiated donepezil, rivastigmine, galantamine or memantine between 1 January 2013 and 30 June 2017 (after a period of ≥180 days with no these medicines) remained on therapy for ( n = 4393), dispensed in the 180 before after further examined prescribed by prescriber other than one Results One‐third study...

To examine the patterns of preventive medicines (PM) use in last year life older adults.This study cohort included individuals (n = 99 809) aged ≥75 years who were their life. PM examined this low-dose aspirin (≤325 mg/day), clopidogrel, dipyridamole, warfarin, dabigatran, statins and bisphosphonates. Logistic regression models influence age, sex, multimorbidity, socioeconomic status, a diagnosis cancer on number type prescribed from 2007 to 2012.The was higher for men compared with women...

This study aimed to document the ways by which missing data were handled in clinical pharmacy research provide an insight into amount of attention paid importance this field research.Our cross-sectional descriptive report evaluated 10 journals affiliated with organizations United States, Canada, Kingdom, and Australia. Randomized controlled trials, cohort studies, case-control studies published 2018 included. The primary outcome measure was proportion that reported handling their methods or...

Abstract Aim To benchmark annual research output from hospital pharmacy departments in Australian principal referral hospitals. Data sources Embase, Medline, and Scopus. Study selection All 29 hospitals listed by the Institute of Health Welfare were searched using institution field 2018–2020. Articles included if an author was affiliated with a department. Conference abstracts, letters, narrative reviews, opinions, commentaries, or editorials excluded. Results A total 261 articles identified...

The aim of this study was to determine the conversion dose ratio between continuous infusion metaraminol and norepinephrine in critically ill patients with shock.A retrospective cohort conducted adult shock admitted an intensive care unit from 29 October 2018 30 2019 who transitioned monotherapy monotherapy. Mean arterial pressure (MAP) doses for both drugs were collected at hourly intervals; 2 hours before 5 after switching defined as (μg.kg-1 .min-1) : .min-1 ) required achieve a similar...

Centenarians represent a population of individuals with delayed disability and are an ideal representation ageing well; however, studies related to medicine use in this scarce. Our study aimed explore the temporal trends associated utilization preventive medicines centenarians.A repeated cross-sectional analysis was conducted from 1st January 2006 31st December 2015 for all ≥100 years old on date dispensing, captured New Zealand's pharmaceutical claims data set. The variable medication...