A5005800013- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Skin Protection and Aging
- Opioid Use Disorder Treatment
- Pain Management and Opioid Use
- Pharmaceutical Economics and Policy
- Air Quality and Health Impacts
- Pregnancy and Medication Impact
- Pharmaceutical studies and practices
- Vitamin D Research Studies
- Health disparities and outcomes
- Reproductive Health and Contraception
- Medication Adherence and Compliance
- Cutaneous Melanoma Detection and Management
- Blood Pressure and Hypertension Studies
- Pharmacological Effects and Toxicity Studies
- Epigenetics and DNA Methylation
- Electroconvulsive Therapy Studies
- Occupational and environmental lung diseases
- Prenatal Substance Exposure Effects
- Advanced Causal Inference Techniques
- Diabetes Treatment and Management
- Ectopic Pregnancy Diagnosis and Management
- Statistical Methods in Clinical Trials
- Climate Change and Health Impacts
The University of Sydney
2007-2024
UNSW Sydney
2017-2024
The University of Western Australia
2024
National Health and Medical Research Council
2024
University of South Australia
2024
Concord Repatriation General Hospital
2008-2013
Concord Hospital
2012
Anzac Research Institute
2008
University of Liverpool
1977
Blackpool Victoria Hospital
1977
The Pharmaceutical Benefits Scheme (PBS) is Australia's national drug subsidy program. This paper provides a practical guide to researchers using PBS data examine prescribed medicine use. Excerpts of the collection are available in variety formats. We describe core components four publicly extracts (the Australian Statistics on Medicines, statistics online, section 85 extract, under co-payment extract). also detail common analytical challenges and key issues regarding interpretation...
Epidemiological studies on ageing have tended to focus women, a phenomenon recognized by sociologists as the feminization of ageing. However, large percentage older people are men. For example, in Australia, 44% those aged 65 and over male, 39% 75 years over. Furthermore, 5–7 year shorter life expectancy for men than women higher death rates at all ages, including suggest that more detailed study health is essential. Probably best known Massachusetts Male Aging Study. baseline, Study were...
Objective To estimate the prevalence of polypharmacy among Australians aged 70 years or more, 2006–2017. Design, setting and participants Analysis a random 10% sample Pharmaceutical Benefits Scheme (PBS) data for people more who were dispensed PBS-listed medicines between 1 January 2006 31 December 2017. Main outcome measures Prevalence continuous (five unique during both April – 30 June October in calendar year) older Australians, estimated number affected 2017; changes concessional...
Abstract Purpose Population‐based observational studies have documented global increases in opioid analgesic use. Many used a single population‐adjusted metric (number of dispensings, defined daily doses [DDDs], or oral morphine equivalents [OMEs]). We combine these volume‐based metrics with measure the number persons dispensed opioids to gain insights into Australian trends prescribed Methods obtained records dispensings (2006‐2015) subsidised under Australia's Pharmaceutical Benefits...
Several new classes of glucose-lowering medications have been introduced in the past two decades. Some, such as sodium-glucose cotransporter 2 inhibitors (SGLT2s), evidence improved cardiovascular outcomes, while others, dipeptidyl peptidase-4 (DPP4s), do not. It is therefore important to identify their uptake order find ways support use more effective treatments.To analyse these among patients with type diabetes.This was a retrospective repeated cross-sectional analysis primary care. Rates...
Objectives To quantify changes in anticoagulant use Australia since the introduction of Non-vitamin K antagonist anticoagulants (NOACs) and to estimate government expenditure. Design Interrupted-time-series analysis quantifying dispensing, before after first Pharmaceutical Benefits Scheme (PBS) NOAC listing August 2009 for venous thromboembolism prevention; expanded stroke prevention non-valvular atrial fibrillation (AF) 2013, up June 2016. Estimated expenditure on PBS-listed anticoagulants....
Objective: To describe values of serum prostate-specific antigen (PSA) in older men without diagnosed prostate cancer, categorised by age and country birth, to self-reported cancer screening. Design, participants setting: A cohort study (the Concord Health Ageing Men Project) involving a representative sample 1434 eligible community-dwelling with no diagnosis who were aged 70 years over living defined geographic area Sydney, baseline data collected between 28 January 2005 4 June 2007. Main...
Abstract Background Medicine prescribing for children is impacted by a lack of paediatric‐specific dosing, efficacy and safety data many medicines. Objectives To estimate the prevalence medicine use among rate ‘off‐label’ according to age at dispensing. Methods We used population‐wide primarily outpatient dispensing claims 15% Australian (0–17 years), 2013–2017 ( n = 840,190). estimated prescribed child's (<1 year, 1–5 years, 6–11 12–17 years) defined as medicines without age‐appropriate...
The lifetime use of combination antiretroviral therapy (cART) highlights the need to understand patterns and factors associated with adherence cART. In this cohort study using a 10% random sample dispensing claims data for eligible Australians, we identified 2042 people dispensed cART between January 2016 December 2017 (mean age 48.0 ± 12.0 years old, 88.6% male, 85.9% treatment experienced). We considered be adherent if proportion coverage days was ≥80% in 360 after their first observed...
Abstract Purpose Medicine dispensing data require extensive preparation when used for research and decisions during this process may lead to results that do not replicate between independent studies. We conducted an experiment examine the impact of these on a study measuring discontinuation, intensification, switching in cohort patients initiating metformin. Methods Four Australian sites independently developed HARmonized Protocol template Enhance Reproducibility (HARPER) protocol executed...
ABSTRACT Background The Medicines Intelligence (MedIntel) Data Platform is an anonymised linked data resource designed to generate real‐world evidence on prescribed medicine use, effectiveness, safety, costs and cost‐effectiveness in Australia. Results platform comprises Medicare‐eligible people who are ≥18 years residing New South Wales (NSW), Australia, any time during 2005–2020, with administrative dispensed prescription medicines (Pharmaceutical Benefits Scheme), health service use...
Aims We investigated anticholinergic medicines use among older adults initiating dementia medicines. Methods used Pharmaceutical Benefits Scheme dispensing claims to identify patients who initiated donepezil, rivastigmine, galantamine or memantine between 1 January 2013 and 30 June 2017 (after a period of ≥180 days with no these medicines) remained on therapy for ( n = 4393), dispensed in the 180 before after further examined prescribed by prescriber other than one Results One‐third study...
Abstract Introduction Fentanyl‐related overdose is an ongoing concern among countries with high prescription opioid utilisation. This study examines trends in transdermal fentanyl utilisation and fatal across Australia between 2003 2015, overall, by age/sex. Methods was a retrospective nationwide of dispensings coronial records. Transdermal examined using Pharmaceutical Benefits Scheme dispensing Details overdoses were extracted from the National Coronial Information System. Results...
Aims: Oral retinoids are teratogenic in pregnancy, and contraception is recommended to prevent pregnancy.This study assessed the demographic characteristics trends use of prescription among reproductive-aged women (15-44 years) Australia.Methods: Pharmaceutical Benefits Scheme (PBS) dispensing claims were used from a 10% random sample Australian between 2013 2021.Annual numbers described.Each retinoid was analysed for whether there concomitant contraceptive within an appropriate time frame...
Abstract The Medicines Intelligence (MedIntel) Data Platform is an anonymised linked data resource designed to generate real-world evidence on prescribed medicine use, safety, costs and cost-effectiveness in Australia. platform comprises Medicare-eligible people who are ≥18 years residing New South Wales (NSW), Australia, any time during 2005-2020, with dispensed prescription medicines (Pharmaceutical Benefits Scheme), health service use (Medicare Schedule), emergency department visits (NSW...
Oral retinoids are teratogenic, and pregnancy avoidance is an important part of retinoid prescribing. Australia does not have a standardised prevention programme for women using oral retinoids, the contraception strategies who use well understood. The objectives were to determine trends in prescription among Australian reproductive-aged whether dispensed used concomitantly.
Following the occurrence of hepatic fibrosis and angiosarcoma in polyvinyl chloride autoclave workers, a screening programme was set up for workers at risk large production plant. There no significant difference liver function tests between control group men same factory, not exposed to vinyl chloride. Four out 422 were found have enlarged spleens compared with none 202 controls. Liver biopsies from selected cases showed pathological changes, although there minimal increase portal tract...
Abstract Purpose Opioids provide effective analgesia for most cancer patients, but little is known about individual‐level opioid use after diagnosis. We examined the patterns of and factors associated with in older people diagnosed cancer. Methods used Department Veterans' Affairs (DVA) client data linked New South Wales (NSW) Cancer Registry Repatriation Pharmaceutical Benefits Scheme data. included aged ≥65 years NSW, Australia 2005 to 2015. 12 months diagnosis cause‐specific hazards...