Lusha Zhu

ORCID: 0000-0001-8717-6356
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About
Contact & Profiles
Research Areas
  • Neural and Behavioral Psychology Studies
  • Psychology of Moral and Emotional Judgment
  • Experimental Behavioral Economics Studies
  • Mental Health Research Topics
  • Decision-Making and Behavioral Economics
  • Neural dynamics and brain function
  • Functional Brain Connectivity Studies
  • Psychopathy, Forensic Psychiatry, Sexual Offending
  • Deception detection and forensic psychology
  • Evolutionary Game Theory and Cooperation
  • Action Observation and Synchronization
  • Neurotransmitter Receptor Influence on Behavior
  • Posttraumatic Stress Disorder Research
  • Stress Responses and Cortisol
  • Language and cultural evolution
  • Child and Animal Learning Development
  • Memory and Neural Mechanisms
  • Big Data and Business Intelligence
  • Big Data Technologies and Applications
  • Organizational Leadership and Management Strategies
  • Gambling Behavior and Treatments
  • Psychology of Social Influence
  • Social and Intergroup Psychology
  • Game Theory and Applications
  • Complex Systems and Decision Making

Peking University
2016-2024

Center for Life Sciences
2016-2024

McGovern Institute for Brain Research
2017-2024

Chinese Institute for Brain Research
2016-2022

Virginia Tech
2012-2021

Biomedical Research Institute
2021

The Affiliated Yongchuan Hospital of Chongqing Medical University
2021

Chongqing Medical University
2021

Carilion Clinic
2014-2018

King Center
2017-2018

Decision-making in the presence of other competitive intelligent agents is fundamental for social and economic behavior. Such decisions require to behave strategically, where addition learning about rewards punishments available environment, they also need anticipate respond actions others competing same rewards. However, whereas we know much strategic at both theoretical behavioral levels, relatively little underlying neural mechanisms. Here, show using a multi-strategy paradigm that...

10.1073/pnas.1116783109 article EN Proceedings of the National Academy of Sciences 2012-01-18

Significance Despite extensive research on disadvantageous inequity, little is known about advantageous inequity and whether these two types of involve differential neurocognitive mechanisms. We address questions from the perspective context dependency suggest that are associated with substrates, subserved by different brain regions in particular spatial gradient insular activity. Our findings shed light how social contexts (i.e., interpersonal guilt) integrated into decision making...

10.1073/pnas.1802523115 article EN Proceedings of the National Academy of Sciences 2018-07-30

Major depressive disorder is prevalent and impairing. Parsing neurocomputational substrates of reinforcement learning in individuals with depression may facilitate a mechanistic understanding the suggest new cognitive therapeutic targets.To determine associations among computational model-derived parameters, symptoms, symptom changes after treatment.In this mixed cross-sectional-cohort study, performed reward loss variants probabilistic task during functional magnetic resonance imaging at...

10.1001/jamapsychiatry.2021.1844 article EN cc-by JAMA Psychiatry 2021-07-28

10.1016/j.cub.2015.01.071 article EN publisher-specific-oa Current Biology 2015-03-01

Disproportionate reactions to unexpected stimuli in the environment are a cardinal symptom of posttraumatic stress disorder (PTSD). Here, we test whether these heightened responses associated with disruptions distinct components reinforcement learning. Specifically, using functional neuroimaging, loss-learning task, and computational model-based approach, assessed mechanistic hypothesis that overreactions PTSD arise from anomalous gating attention during learning (i.e., associability)....

10.7554/elife.30150 article EN cc-by eLife 2018-01-09

Disparities in outcomes across social groups pervade human societies and are of central interest to the sciences. How people treat others is known depend on a multitude factors (e.g., others’ gender, ethnicity, appearance) even when these should be irrelevant. However, despite substantial progress, much remains unknown regarding ( i ) set mechanisms shaping people’s behavior toward members different ii extent which can explain structure existing societal disparities. Here, we show...

10.1073/pnas.1719452115 article EN Proceedings of the National Academy of Sciences 2018-09-10

Significance Game theory is used throughout the social and biological sciences to study behavior in interactions. Recent research suggests an important role for dopamine neurotransmitter system these types of decisions. This a competitive game how people varied their decision-making processes related differences set genes that carry out functions required dopaminergic functioning. We found differentially expressed separate brain regions influenced distinct components people’s surprising...

10.1073/pnas.1316259111 article EN Proceedings of the National Academy of Sciences 2014-06-16

Sleep is known to benefit consolidation of memories, especially those motivational relevance. Yet, it remains largely unknown the extent which sleep influences reward-associated behavior, in particular, whether and how modulates reward evaluation that critically underlies value-based decisions. Here, we show neural processing during can selectively bias preferences simple economic choices when sleeper stimulated by covert, cues. Specifically, presenting spoken name a familiar, valued snack...

10.7554/elife.40583 article EN cc-by eLife 2018-12-06

Listener vmPFC simulates speaker utterance choices in a rational, automatic way to recover unstated intent communication.

10.1126/sciadv.abe6276 article EN cc-by-nc Science Advances 2021-03-03

In substance-dependent individuals, drug deprivation and use trigger divergent behavioral responses to environmental cues. These are consonant with data showing that short- long-term adaptations in dopamine signaling similarly sensitive state of use. The literature suggests a state-dependent role learning maintaining substance use; evidence linking both reinforcement addiction provides framework test this possibility.In randomized crossover design, 22 participants current cocaine disorder...

10.1016/j.bpsc.2018.07.009 article EN cc-by-nc-nd Biological Psychiatry Cognitive Neuroscience and Neuroimaging 2018-08-02

10.1016/j.cobeha.2016.09.005 article EN Current Opinion in Behavioral Sciences 2016-09-21

This article discusses about new product design patterns in the big data era, gives designer a rational thinking way, and is way to understand of product. Based on key criteria process, category, element, are used input data, which comprises concrete abstract as an enlargement process for establishment data-driven pattern’s model. Moreover, experiment case conducted verify feasibility pattern. Ultimately, we will conclude that has two patterns: one supporting design, namely...

10.1177/1687814016656805 article EN cc-by Advances in Mechanical Engineering 2016-07-01

Deception is a universal human behavior. Yet longstanding skepticism about the validity of measures used to characterize biological mechanisms underlying deceptive behavior has relegated such studies scientific periphery. Here, we address these fundamental questions by applying machine learning methods and functional magnetic resonance imaging (fMRI) signaling games capturing motivated deception in participants. First, develop an approach test for presence confounding processes validate past...

10.1073/pnas.2412881121 article EN Proceedings of the National Academy of Sciences 2024-12-06

Social and decision-making deficits are often the first symptoms of a striking number neurodegenerative disorders associated with aging. These includes not only that directly impact dopamine basal ganglia, such as Parkinson's disorder, but also degeneration in which multiple neural pathways affected over course normal The can be dramatic, cases financial fraud, disproportionately affect elderly. Unlike memory motor impairments, however, readily recognized more serious underlying neurological...

10.3389/fnins.2012.00128 article EN cc-by Frontiers in Neuroscience 2012-01-01

The framing effect refers the tendency to be risk-averse when options are presented positively but risk-seeking same negatively during decision-making. This has been found modulated by serotonin transporter gene (SLC6A4) and catechol-o-methyltransferase (COMT) polymorphisms, which on dopaminergic serotonergic pathways associated with affective processing. current study aimed identify new genetic variations of genes that may contribute individual differences in susceptibility framing. Using...

10.1093/scan/nsx062 article EN cc-by-nc-nd Social Cognitive and Affective Neuroscience 2017-04-18

Abstract Both basal ganglia (BG) and orbitofrontal cortex (OFC) have been widely implicated in social non-social decision-making. However, unlike OFC damage, BG pathology is not typically associated with disturbances functioning. Here we studied the behavior of patients focal lesions to either or a multi-strategy competitive game known engage these regions. We find that whereas are significantly impaired, show intact learning economic game. By contrast, when information about strategic...

10.1038/s41467-019-08766-1 article EN cc-by Nature Communications 2019-02-18

Résumé Les dernières décennies ont connu une croissance inédite de notre compréhension des fondements cérébraux la prise décision économique. En particulier, recherche a découvert non seulement localisation régions du cerveau où certains processus lieu, mais également nature variables latentes (économiquement significatives) ainsi que manière dont elles sont liées au comportement. Cette transition d’une lieu économique vers se prend cette niveau cérébral est intégrante à l’identification...

10.3917/rel.783.0047 article FR Recherches économiques de Louvain 2012-11-01

Abstract Deception is a universal human behavior. Yet longstanding skepticism about the validity of measures used to understand biological mechanisms underlying deceptive behavior has relegated such studies scientific periphery. Here we address these fundamental questions by applying novel machine learning methods and functional neuroimaging signaling games capturing motivated deception in participants. First, develop an approach test for presence confounding processes thereby validate past...

10.1101/2024.05.08.593230 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-05-09

Objectives: To investigate the prevalence and associated risk factors of tinnitus in Sichuan Chongqing. Methods: We designed a epidemiological questionnaire. The multi-stage stratified cluster random sampling methods was applied to obtain study subjects six areas (Nanchong, Jiangjin, Fengdu, Yunyang, Suining Ya'an), which were selected for investigation. Home visit completion questionnaires conducted. trained investigators guided respondents fill questionnaires, status on factor...

10.3760/cma.j.cn115330-20201019-00816 article EN PubMed 2021-11-07

Abstract Humans are capable of integrating social contextual information into decision-making processes to adjust their attitudes towards inequity. This context-dependency emerges both when individual is better off (i.e. advantageous inequity) and worse disadvantageous than others. It not clear however, whether the context-dependent processing inequity rely on dissociable or shared neural mechanisms. Here, by combining an interpersonal interactive game that gave rise guilt different versions...

10.1101/243428 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2018-01-05
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