A5035517610- Cardiac Arrhythmias and Treatments
- Mechanical Circulatory Support Devices
- Atrial Fibrillation Management and Outcomes
- Multiple Myeloma Research and Treatments
- Acute Myocardial Infarction Research
- Diabetes Treatment and Management
- Cardiac Structural Anomalies and Repair
- Platelet Disorders and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Pericarditis and Cardiac Tamponade
- Metabolism, Diabetes, and Cancer
- COVID-19 and Mental Health
- Neurotransmitter Receptor Influence on Behavior
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Fuel Cells and Related Materials
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Infective Endocarditis Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac electrophysiology and arrhythmias
- Healthcare professionals’ stress and burnout
- Receptor Mechanisms and Signaling
- Chemokine receptors and signaling
The General Hospital of Heraklion "Venizeleio-Pananio"
2011-2025
Chania General Hospital ”St. George”
2023-2024
Onassis Cardiac Surgery Center
2017-2021
General-Maternity District Hospital Helena Venizelou
2021
University of Crete
2013-2015
Regulator of G protein signaling 4 (Rgs4) is a signal transduction that controls the function monoamine, opiate, muscarinic, and other protein-coupled receptors via interactions with Gα subunits. Rgs4 expressed in several brain regions involved mood, movement, cognition, addiction regulated by psychotropic drugs, stress, corticosteroids. In this study, we use genetic mouse models viral-mediated gene transfer to examine role actions antidepressant medications. We first analyzed human...
Introduction: Acute cardiorenal syndrome (ACRS) is a common complication of acute heart failure (AHF), leading to worse outcomes and therapeutic challenges. This study aimed identify clinical parameters associated with ACRS evaluate its impact on prognosis in hospitalized AHF patients. Methods: prospective observational included patients for at the Venizelio Cardiology Department from February November 2023. Demographic characteristics, comorbidities, medications, laboratory...
The striatal protein Regulator of G-protein signaling 9-2 (RGS9-2) plays a key modulatory role in opioid, monoamine, and other G-protein-coupled receptor responses. Here, we use the murine spared-nerve injury model neuropathic pain to investigate mechanism by which RGS9-2 nucleus accumbens (NAc), brain region involved mood, reward, motivation, modulates actions tricyclic antidepressants (TCAs). Prevention action NAc increases efficacy TCA desipramine dramatically accelerates its onset...
Abstract Background COVID-19 has challenged the health system organization requiring a fast reorganization of diagnostic/therapeutic pathways for patients affected by time-dependent diseases such as acute coronary syndromes (ACS). Aim To describe ACS hospitalizations, management, and complication rate before after pandemic was declared. Design Ecological retrospective study. Methods: We analyzed aggregated epidemiological data all > 18 years old admitted in twenty-nine hub cardiac...
Abstract Angiogenesis is a complex process essential for the growth, invasion, and metastasis of various malignant tumours, including multiple myeloma (MM). Various angiogenic cytokines have been implicated in process. Among them, platelet‐derived growth factor‐AB (PDGF‐AB) has reported to be potent stimulator angiogenesis many solid tumours haematological malignancies, MM. The aim study was investigate relationship between PDGF‐AB, microvascular density (MVD), cytokines, such as basic...
An essential cytokine system for the osteoclast biology in multiple myeloma (MM) consists of receptor activator NF-κB ligand (RANKL), its (RANK), and soluble decoy receptor, osteoprotegerin (OPG). Myeloma cells cause imbalance OPG/RANKL interactions. We measured serum levels OPG, (s) RANKL, sRANKL/OPG ratio, markers disease activity [LDH, CRP, interleukin-6 (IL-6), β2-microglobulin (B2M)], angiogenic factors [hepatocyte growth factor (HGF), vascular endothelial (VEGF)], 54 newly diagnosed MM...
Recurrent pericarditis poses a significant challenge to clinicians, particularly when patients are unresponsive or intolerant conventional treatments. Accurate diagnosis of recurrent pericarditis, potentially facilitated by collaboration with other medical specialties, is crucial for ensuring timely and appropriate treatment symptoms prevention further episodes. We present case 52-year-old male patient history multiple episodes who was admitted the Cardiology Department due another...
Concurrent evidence about cardiogenic shock (CS) characteristics, treatment and outcome does not represent a global spectrum of patients is therefore limited. The aim this study was to investigate these regional differences.To differences in presentation treatments outcomes treated with all types single calendar year on multi-national level. Consecutive from 19 tertiary care hospitals 13 countries CS who were between January 1, 2018 December 31, enrolled study.In total, 699 included study....
Abstract Funding Acknowledgements None. Background Thrombophilia and elevated Lp(a) levels have been studied as risk factors predisposing to cardiovascular events. There is no evidence suggesting that the common mutations causing thrombophilia or alone could be regarded independent for acute coronary syndromes. Purpose To compare frequency of simultaneous presence thrombophilic along with in young patients presenting syndrome (ACS) compared those without ACS. Methods We retrospectively...
Abstract Funding Acknowledgements None. Introduction Patients admitted due to acute coronary syndrome (ACS) are stratified using Killip class for the severity of post myocardial infarction (MI) heart failure (HF). classification is mainly based on clinical examination and overt signs symptoms usually needed be present. Purpose To evaluate subclinical congestion with lung ultrasound (LUS) in patients presenting syndrome. Methods For a period 4 years, we recorded presented emergency department...
Abstract Funding Acknowledgements None. Background Apical ballooning is considered the typical form of Takotsubo syndrome (TTS) and occurs in about 75-80% cases. Midventricular (MV) most frequent atypical variant represents 15% TTS. Clinical analytical characteristics, early complications risk cerebrovascular events (CVEs) between these two specific groups are poorly studied. Purpose study To investigate clinical profile, laboratory variables, in-hospital one-year CVEs MV variants Methods we...
Abstract Funding Acknowledgements None. Background Nt-proBNP is frequently used in the diagnosis of acute decompensated heart failure (ADHF). However, there are some patients that although they have clinical features ADHF present with paradoxically low levels. Purpose To record and epidemiological characteristics presenting levels compare them those high Methods We retrospectively analyzed data from admitted our department, for a period 2 years divided groups : group (BNP<300 pg/ml)...
Abstract Background High-sensitive troponin (hs-cTnI/hs-cTnT) assays are preferred for detecting myocardial injury and can be elevated in various clinical conditions other than acute infarction including supraventricular tachycardias (SVTs). Patients with SVT troponinemia often need further evaluation coronary artery disease (CAD), guiding the management. Purpose The purpose of this study is to characterize patients tachycardia (atrioventricular nodal reentrant tachycardia-AVNRT,...
Abstract Introduction Acute cardiorenal syndrome (ACRS) encompasses a spectrum of disorders that induce acute kidney injury in patients with heart failure (AHF). The occurrence ACRS has been associated worse prognosis the literature and its management often poses therapeutic challenge. Purpose purpose this study is to record most frequent comorbidities other clinical, biochemical imaging parameters assess prognostic value occurrence. Materials-Methods: We recorded demographic...
Abstract Introduction Despite the widespread use of anthracyclines (ANT) and anti-HER2 agents as trastuzumab (TZB) in chemotherapy schemes, it is known potential cardiotoxic effects that can limit intensity duration treatments. The clinical trial "DECLARE-TIMI 58" (Dapagliflozin Effect on Cardiovascular Events-Thrombolysis Myocardial Infarction 58), demonstrated dapagliflozin, a Sodium glucose cotransporter 2 inhibitor, reduces composite end point cardiovascular death/hospitalization for...
Abstract Background Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are one of the cornerstones in treatment patients with heart failure (HF) , regardless ejection fraction (EF) or presence diabetes mellitus (DM). Other types medications used like angiotensin converting enzyme (ACEi) beta-blockers (BB) have shown some degree cardioprotection high risk receiving cardiotoxic chemotherapy, but data on SGLT2i very limited. Purpose To examine possible differences development anthracycline...
[1]¿p#1 Background: Patients with paroxysmal supraventricular tachycardia (PSVT) and elevated cardiac troponin (cTn) levels often require further evaluation for coronary artery disease (CAD), which guides clinical management. Objective: To characterize patients PSVT cTn values, to evaluate the association coexisting CAD as well probable underlying mechanisms of elevation. Methods: We recorded demographic characteristics, main symptoms, comorbidities, chronic antiarrhythmic medication,...
Abstract Funding Acknowledgements Type of funding sources: None. Introduction Hospitalization due to acute coronary syndromes (ACS) usually is the occasion that leads diagnosis type 2 diabetes mellitus (T2DM). Current literature suggests severity ACS could be associated with presence and DM. Purpose To study reliability HbA1c in T2DM phase ACS, as well possible correlation between ACS. Methods We evaluated 160 consecutive patients admitted was measured on day 1 90. >6.5% used diagnose...