A5061465699- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Trace Elements in Health
- Chronic Lymphocytic Leukemia Research
- Heavy Metal Exposure and Toxicity
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Cancer Treatment and Pharmacology
- T-cell and Retrovirus Studies
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Iron Metabolism and Disorders
- Acute Myeloid Leukemia Research
- Peptidase Inhibition and Analysis
- Acute Lymphoblastic Leukemia research
- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Head and Neck Cancer Studies
- Neonatal Health and Biochemistry
- Heme Oxygenase-1 and Carbon Monoxide
The Cancer Institute Hospital
2014-2024
Memorial Sloan Kettering Cancer Center
2023-2024
Japanese Foundation For Cancer Research
2014-2023
Okayama University
2022-2023
Kettering University
2022
Fukuoka University
2001-2021
Yamaguchi Red Cross Hospital
2018-2021
The University of Tokyo
2016-2019
Palmetto Hematology Oncology
2017
Tottori University of Environmental Studies
2013
Exposure to dioxins has been shown contribute the development of inflammatory diseases, such as atherosclerosis. Macrophage-mediated inflammation is a critical event in initiation Previously, we showed that treatment macrophages with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads aryl hydrocarbon receptor (AhR)-dependent activation mediators and formation cholesterol-laden foam cells. However, mechanisms responsible for atherosclerotic lesions mediated through AhR have not identified.An...
There are large inter- and intraspecies differences in susceptibility to dioxin-induced toxicities. A critical question risk assessment of dioxin related compounds is whether humans sensitive or resistant their The diverse responses mammals strongly influenced by functional polymorphisms the arylhydrocarbon receptor (AHR). To characterize mediated human AHR (hAHR), we generated a mouse possessing hAHR instead AHR. Responses these mice 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD)...
E2F-1 is capable of promoting both cell cycle progression and apoptosis. The latter important for suppressing untoward expansion proliferating cells. In this study, we investigated its underlying mechanisms. E2F-1-induced apoptosis was accompanied by caspase-9 activation inhibited a specific inhibitor in K562 sublines overexpressing E2F-1. enhanced the expression Apaf-1 without cytosolic accumulation cytochrome c. Apaf-1-deficient melanoma lines were resistant to E2F-1, indicating that an...
Despite being the mainstay of management for cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS), there is limited data regarding impact tocilizumab (TCZ) corticosteroids (CCS) on chimeric antigen receptor (CAR) T-cell efficacy in multiple myeloma (MM). The present study aims to evaluate prognostic these immunosuppressants recipients BCMA- or GPRC5D-directed CAR T cells relapsed/refractory MM. Our retrospective cohort involved patients treated with...
Abstract B-cell-maturation-antigen (BCMA)-directed therapies are highly active for multiple myeloma, but infections emerging as a major challenge. In this retrospective, single-center analysis we evaluated infectious complications after BCMA-targeted chimeric-antigen-receptor T-cell therapy (CAR-T), bispecific-antibodies (BsAb) and antibody-drug-conjugates (ADC). The primary endpoint was severe (grade ≥3) infection incidence. Amongst 256 patients, 92 received CAR-T, 55 BsAb 109 ADC....
Metallothionein (MT) is a low molecular mass protein inducible by heavy metals such as cadmium (Cd), zinc, and copper, having high affinity for these metals. In the present study, we investigated immunohistological localization of MT in brains rats mice. adult rat brain, almost no immunostaining was observed, whereas mouse brain strong found ependymal cells, some glial arachnoid, pia mater. No detected neurons endothelial cells. younger (1-3 weeks old), observed choroid plexus epithelium,...
Metallothionein (MT) is a cysteine-rich, low molecular weight protein inducible by heavy metal ions and various endogenous factors. Using an indirect immunofluorescent technique, we studied the localization of MT in developing rat tissues (kidney, small intestine, liver). In kidney neonate fetus, was found both cytoplasm nucleus renal tubular epithelia. Localization changed with shift zonation cortex during development. mainly inner zone but not tubules neogenic on Day 4. Until 18, cells...
Epidemiological and laboratory studies suggested that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects glucose homeostasis increases the incidence of type 2 diabetes mellitus. To evaluate effects TCDD on insulin secretion from islets Langerhans (islets), we designed in vivo, ex vivo vitro experiments. For experiment, male C57BL/6J aryl hydrocarbon receptor (AhR)-null mice were injected intraperitoneally with (10 microg kg(-1) b.w.), fasted for 12 h administered 24...
Histone deacetylases (HDACs) are globally implicated in the growth and differentiation of mammalian cells; however, relatively little is known about their specific roles hematopoiesis. In this study, we investigated expression HDACs human hematopoietic cells functions during The was very low progenitor cells, which accompanied by histone hyperacetylation. were detectable more differentiated progenitors erythroid precursors but down-regulated mature myeloid especially granulocytes. contrast,...
T cell-mediated immune function, here measured as the contact hypersensitivity reaction, is readily suppressed by moderate exposure of mice to ultraviolet B (UVB) or solar-simulated radiation (SSUV), topical application <i>cis</i>-urocanic acid. The effect A (UVA) on function has been unclear. Here we have demonstrated that when UVA from a fluorescent tube source was rigorously filtered remove contaminating UVB radiation, it immunologically innocuous at physiologically relevant...
We studied the immunohistological localization of metallothionein (MT), a low molecular weight metal binding protein, in male rat genital organs (testis, epididymis, ejaculatory duct, seminal vesicle, coagulating gland, and prostate) by use avidin-biotin-peroxidase complex method. MT concentrations testis, prostate ranged from 15-30 micrograms/g tissue. In seminiferous tubules with mature spermatozoa exhibited weak staining, whereas containing differentiating spermatogenic cells but not...
Metallothioneins, a group of cysteine-rich heavy-metal binding proteins, are induced in the regenerating rat liver response to stimuli evoked by partial hepatectomy. We have investigated expression metallothionein genes and proto-oncogenes (c-fos, c-jun c-myc), as well specific localization cells after Metallothionein mRNA was detected early 3 hr reached maximal level 6 hr. Expression apparently preceded elevation protein because latter 18 hepatectomy, followed decrease until 70 Hepatocytes...
Tumorigenesis is a complex process involving genetic, epigenetic, and metabolic alterations. Gestational arsenic exposure has been shown to increase hepatic tumors in adult male offspring of C3H mice, which spontaneously develop often harboring activating Ha-ras mutation. We explored tumor-promoting changes by gestational with focus on mutation gene expression changes. The results this study demonstrated that particularly increased C61A Real-time PCR analyses the normal livers showed two...
To elucidate a protective role of metallothionein (MT) in the manifestation inorganic mercury toxicity, we studied susceptibility MT-null mice to renal toxicity mercuric chloride. Because (J) are genetic background 129/Sv strain, were used as wild-type controls. Nine-week-old male and given subcutaneous injections chloride at doses 10 40 micromol/kg. The basal MT level kidney was undetectable (<0.2 microg/g tissue) approximately 2.5 tissue mice. sensitivity markedly enhanced compared with...
Objective Ouabain-like factor (OLF), assayed as ouabain-like immunoreactivity (OLI), is thought to represent an endogenous digitalis-like factor. We found increased plasma OLI during the surgical removal of a pheochromocytoma. The elution volume extracted from and pheochromocytoma tissue was same that for authentic ouabain, using reverse phase high-performance liquid chromatography. present study performed characterize OLF culture supernatant rat cell line, PC12 cells. Design chromatographic...