A5011694902- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Protein Kinase Regulation and GTPase Signaling
- Cardiovascular and exercise physiology
- Metabolism, Diabetes, and Cancer
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Biomedical and Engineering Education
- Biotin and Related Studies
- Neuroinflammation and Neurodegeneration Mechanisms
University of Copenhagen
2022-2023
Medical University of Vienna
2018
Addiction to psychostimulants (ie, amphetamines and cocaine) imposes a major socioeconomic burden. Prevention treatment represent unmet medical needs, which may be addressed, if the mechanisms underlying psychostimulant action are understood. Cocaine acts as blocker at transporters for dopamine (DAT), serotonin (SERT), norepinephrine (NET), but substrates that do not only block uptake of monoamines also induce substrate efflux by promoting reverse transport. Reverse transport has been focus...
Abstract Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative characterized by the accumulation of aggregated amyloid beta (Aβ) hyperphosphorylated tau along with slow decline in cognitive functions. Unlike advanced AD, initial steps AD pathophysiology have been poorly investigated, partially due to limited availability animal models focused on early, plaque-free stages disease. The aim this study was evaluate early behavioral, anatomical molecular alterations...
ABSTRACT The dopamine transporter (DAT) plays a crucial role in regulating the brain’s (DA) homeostasis. Atypical DAT deficiency syndrome (DTSD) is disease characterized by early-onset parkinsonism and comorbid psychiatric symptoms, but pathobiological processes that link dysfunction to both symptoms are unknown. Here, we present genetic mouse model of atypical DTDS expresses two coding variants, DAT-I312F DAT-D421N, derived from patient diagnosed with ADHD parkinsonism. Phenotypic...