A5018773367- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Computational Drug Discovery Methods
- Spine and Intervertebral Disc Pathology
- Cholinesterase and Neurodegenerative Diseases
- Facial Trauma and Fracture Management
- Periodontal Regeneration and Treatments
- Coconut Research and Applications
- Surgical Sutures and Adhesives
- Scientific and Engineering Research Topics
- Curcumin's Biomedical Applications
- Thallium and Germanium Studies
- Nanoparticles: synthesis and applications
- Human Health and Disease
- Electromagnetic Fields and Biological Effects
- Neuroendocrine regulation and behavior
- Phytochemical Studies and Bioactivities
- Nanowire Synthesis and Applications
- Memory and Neural Mechanisms
- Anesthesia and Neurotoxicity Research
- Nicotinic Acetylcholine Receptors Study
- Spaceflight effects on biology
- Neurogenesis and neuroplasticity mechanisms
- X-ray Diffraction in Crystallography
- RNA Interference and Gene Delivery
Indian Institute of Technology BHU
2019-2025
Banaras Hindu University
2019-2024
Adamas University
2024
Paclitaxel (PAC) has been approved by FDA for clinical use (Taxol®), yet dose-dependent severe toxicity due to the adjuvant Cremophor EL® in combination with ethanol is a major drawback. The drawbacks of current therapy can be overcome (i) finding suitable vehicle that cannot only bypass above but also used deliver drugs orally and (ii) combining PAC some other chemotherapeutics have enhanced therapeutic efficacy. In work, we folic acid (FA) functionalized bovine milk-derived exosomes oral...
We report herein the rational design, synthesis and evaluation of a library 21 S‐acetophenylhydrazones 5‐methyl‐1,3,4‐thiadiazole‐2‐thiol bearing substituted benzylidene moiety (compounds 5a‐5u). Compound 5f ((E)‐N'‐(2,6‐dichlorobenzylidene)‐2‐((5‐methyl‐1,3,4‐thiadiazol‐2‐yl)thio)acetohydrazide) emerged as most potent SHP2 inhibitor (IC50 = 0.120 ± 0.006 μM). Further, cell‐based studies revealed its moderate yet best‐in‐library cytotoxicity against MCF‐7 cells 86.46 2.32 μM) in...
Background: Inorganic biomaterials are biologically active and used as implants drug delivery system. They have therapeutically elements present in their framework that released the physiological milieu. Release of these dopants above supraphysiological limit may produce adverse effects physicochemical interactions with loaded drugs. Therefore, this necessitates evaluating vivo release kinetics, biodistribution, excretion profiles from barium-doped bioglass (BaBG) has potential...
Abstract Alzheimer's disease (AD) is a complex, degenerative condition linked to memory loss and cognitive degradation. The phenyl sulfonyl‐pyrimidine derivatives containing dimethoxy‐chloro substituent ( BS ‐ 10 22 ) were previously recognized as multitarget‐directed ligands (MTDLs) due their ability inhibit acetylcholinesterase (AChE) at low nanomolar concentrations (IC 50 =47.33±0.02 51.36±0.04 nM respectively) while also reducing amyloid beta (A β aggregation. In the current...
In recent years, scientific communities have been concerned about the potential health effects of periodic electromagnetic field exposure (≤1 h/d). The objective our study is to determine impact extremely low-frequency pulsed fields (ELF-PEMF) (1-3 mT, 50 Hz) on mouse fibroblast (red fluorescent protein (RFP)-L929) cells and adult Wistar rats gain a comprehensive understanding biological effects. We observed that RFP-L929 exhibits no significant changes in cell proliferation morphology but...
Herein, we unveil a remarkable finding for synthesizing room-temperature-stable, nontoxic, ultrasmall free-standing diamond cubic tin nanocrystals (α-Sn) with beta forms in the aqueous phase, avoiding conventional approaches that typically use toxic elements or large reactive substrates (Si/InSb) to stabilize α-Sn above 13 °C. first time, demonstrate successful synthesis of alpha extraordinary stability up 80 °C and phase at room temperature, which was supported by powder X-ray diffraction...