A5034258800- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Metal Alloys Wear and Properties
- Microstructure and Mechanical Properties of Steels
- Molecular Sensors and Ion Detection
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Advanced Fluorescence Microscopy Techniques
- Chemical Synthesis and Analysis
- Metallurgy and Material Forming
- Supramolecular Self-Assembly in Materials
- Cultural Heritage Materials Analysis
- Electron Spin Resonance Studies
- Biotin and Related Studies
- Chalcogenide Semiconductor Thin Films
- Quantum Dots Synthesis And Properties
- High Temperature Alloys and Creep
- Substance Abuse Treatment and Outcomes
- Electrochemical sensors and biosensors
- Protein Interaction Studies and Fluorescence Analysis
- Perovskite Materials and Applications
- Biochemical effects in animals
- Advanced MRI Techniques and Applications
- Lipid Membrane Structure and Behavior
- Sleep and Wakefulness Research
Rice University
2016-2020
Indian Institute of Engineering Science and Technology, Shibpur
2005-2018
Institute of Engineering Science
2018
National Institute of Mental Health
1996
Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating. Here, we used luminescence resonance energy transfer measurements to map distances between full-length, functional stargazin expressed HEK293 cells determine ensemble structural changes due stargazin. addition, single-molecule fluorescence...
Mechanistic details about how local physicochemistry of porous interfaces drives protein transport mechanisms are necessary to optimize biomaterial applications. Cross-linked hydrogels made stimuli-responsive polymers have potential for active capture and release through tunable steric chemical transformations. Simultaneous monitoring dynamic changes in both interfacial polymer structure is an experimental challenge. We use single-particle tracking (SPT) fluorescence correlation spectroscopy...
The intracellular C-terminal domain (CTD) of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor undergoes phosphorylation at specific locations during long-term potentiation. This modification enhances conductance through the ion channel and thus potentially plays a crucial role in modulating trafficking signaling. However, because CTD structure is largely unresolved, it difficult to establish if induces conformational changes that might play enhancing conductance. Herein,...
In this study, a combinatorial approach was developed for fabricating nanostructured composite semiconductor matrices, which exhibited promising photo-response, appreciable photo-current potential and enhanced energy conversion efficiency.
AbstractThe mechanism of accelerated graphitization in hot forged white cast iron has been analysed and a mathematical relationship between graphite content (vol.-%) the process variables determined. The power law variation with annealing time formulated present investigation suggests that first stage is diffusion controlled precipitation process.MST/219
Phosphorylation at the intracellular C-terminal domain (CTD) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors induces conformational rigidity. Such alterations to AMPA receptor influence its functional responses, which are involved in multiple synaptic processes and neuronal signaling. The structure CTD still remains unresolved, poses challenges toward providing a mechanism for process phosphorylation deciphering role each step causing resultant behavior. Herein, we...
Mechanistic details about how local physicochemistry of porous interfaces drive protein transport mechanisms are necessary to optimize biomaterials applications. Cross-linked hydrogels made stimuli-responsive polymers have potential for active capture and release through tunable steric chemical transformations. Simultaneous monitoring dynamic changes in both interfacial polymer structure is an experimental challenge. We use single-particle tracking (SPT) fluorescence correlation spectroscopy...
The mechanism of accelerated graphitization in hot forged white cast iron has been analysed and a mathematical relationship between graphite content (vol.-%) the process variables determined. power law variation with annealing time formulated present investigation suggests that first stage is diffusion controlled precipitation process.MST/219