A5066670680- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Extracellular vesicles in disease
- Receptor Mechanisms and Signaling
- Nanocluster Synthesis and Applications
- Adipose Tissue and Metabolism
- Nanoplatforms for cancer theranostics
- Cardiac electrophysiology and arrhythmias
- Nanoparticle-Based Drug Delivery
- Exercise and Physiological Responses
- Advanced biosensing and bioanalysis techniques
- RNA regulation and disease
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Pancreatic function and diabetes
- Photochromic and Fluorescence Chemistry
- Molecular Sensors and Ion Detection
- Thermoregulation and physiological responses
- Nanoparticles: synthesis and applications
- Photoreceptor and optogenetics research
- Photoacoustic and Ultrasonic Imaging
- MicroRNA in disease regulation
- Advanced Nanomaterials in Catalysis
Southeast University
2018-2024
University of Michigan
2023
State Key Laboratory of Digital Medical Engineering
2018-2022
Sindh Institute of Urology and Transplantation
2018-2022
Datta Meghe Institute of Medical Sciences
2022
Southeast University
2021
The University of Texas Health Science Center at Houston
2016-2020
University of Sindh
2017
Discovery Institute
2015-2016
Sanford Burnham Prebys Medical Discovery Institute
2015-2016
Sarcolipin (SLN) is a novel regulator of sarcoplasmic reticulum Ca2+ ATPase (SERCA) in muscle. SLN binding to SERCA uncouples transport from ATP hydrolysis. By this mechanism, promotes the futile cycling SERCA, contributing muscle heat production. We recently showed that plays an important role cold- and diet-induced thermogenesis. However, detailed mechanism how regulates metabolism remains unclear. In study, we used both knockout (Sln−/−) skeletal muscle-specific overexpression (SlnOE)...
Multimodal bioimaging is a powerful tool for visualizing the abnormal state at target site of related disease. In this study, we used multimodal imaging techniques such as computed tomography, fluorescence, and magnetic resonance to improve early precise diagnosis tumor. Herein, reported facile in situ biosynthesis iridium iron oxide nanoclusters (NCs) cancer cells or tumor tissue. These NCs are probe image sensitivity specificity toward applied vivo form an capable enhancing Our observation...
Sarcolipin (SLN) is a regulator of sarcoendoplasmic reticulum calcium ATPase in skeletal muscle. Recent studies using SLN-null mice have identified SLN as key player muscle thermogenesis and metabolism. In this study, we exploited overexpression ( Sln OE ) mouse model to determine whether increased level affected contractile properties, exercise capacity/fatigue, metabolic rate whole animals isolated We found that are more resistant fatigue can run significantly longer distances than...
Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating. Here, we used luminescence resonance energy transfer measurements to map distances between full-length, functional stargazin expressed HEK293 cells determine ensemble structural changes due stargazin. addition, single-molecule fluorescence...
Glioblastoma (GBM) remains a challenging malignancy due to its aggressive nature and the lack of efficacious therapeutic interventions. Nanotechnology-based approaches exhibit promise in GBM treatment; however, successful translation these strategies from preclinical models clinical settings is hindered by inefficient nanoparticle clearance vital organs. Addressing this concern, we investigated potential amrubicin (AMR) encapsulated within poly (lactic-co-glycolic acid) nanoparticles...
Lobular carcinoma (LC) presents unique diagnostic challenges due to its subtle imaging characteristics and asymptomatic presentation, often leading delays in diagnosis treatment. This mini-review critically examines both traditional advanced modalities used detect manage LC, including mammography, ultrasound, digital breast tomosynthesis (DBT), contrast-enhanced mammography (CEM), magnetic resonance (MRI), breast-specific gamma (BSGI). Traditional like while widely used, have limitations,...
We have utilized HepG2 cancer cells for the <italic>in situ</italic> biosynthesis of silver and iron oxide nanoclusters. The self-assembled nanoclusters loaded on exosomes could be to bioimage through fluorescence imaging.
Fast excitatory synaptic transmission in the mammalian central nervous system is mediated by glutamate-activated α-amino-5-methyl-3-hydroxy-4-isoxazole propionate (AMPA) receptors. In neurons, AMPA receptors coassemble with transmembrane receptor regulatory proteins (TARPs). Assembly TARP γ8 alters biophysical properties of receptor, producing resensitization currents continued presence glutamate. Using single-channel recordings, we show that under resensitizing conditions, GluA2 primarily...
Breast cancer is a disease with diverse clinical symptoms, molecular profiles, and its nature to response therapeutic treatments. Radiotherapy (RT), along surgery chemotherapy part of treatment in breast cancer. The aim present study was investigate pre post effects radiotherapy serum fatty acids lipids profile patients In this comparative as well follow up study, Serum were performed by gas chromatography Microlab for analysis lipid profile. Among free total the major saturated (SFAs) (pre...
Abstract Background Glioblastoma multiforme (GBM) is one of the most daunting issues to modern therapeutics, with a higher mortality rate post-diagnosis. Temozolomide (TMZ) only available treatment; however, frequent resistance leaves oncologists at dead end. Therefore, new approaches circumvent GBM are highly desired. We have employed TiO 2 nanosticks loaded TMZ as nanomedicine for TMZ-resistant resection in this contribution. Results The ultrasonication triple-action effect could greatly...
Bio-nanotechnology based cancer therapeutics exponentially increase every year. A therapeutic strategy to induce intracellular reactive oxygen species (ROS) has received promising success in oncotherapy. In this study, the new been exploited by treatment of iridium (Ir) and Fe2+ ions with cells biosynthesize biocompatible fluorescent oxide (IrO2) iron nanoclusters (NCs) under specific redox heterogeneous microenvironment these diseased tumors. The hydroxyl radical produced presence H2O2...
Therapy against cancer remains a daunting issue for human health, despite remarkable innovations in many areas of pathology. In situ biosynthesized nanoclusters bestow novel remedy carcinogenic cell imaging. Exosomes have received special attention as an efficient tool the diagnosis various diseases, including cancers. All types cells (healthy or diseased) generate exosomes, making them significantly unique relevant disease and treatment. this contribution, we exploit possibility utilizing...
We studied the correlation of sonographic and digital mammographic features with molecular classification breast cancer. Imaging from 313 patients preliminary ultrasound mammogram between November 2017 May 2020 were compared histopathology immunohistochemical analysis for prediction also devised a score called “sono-mammometry” consisting few simple imaging which can easily be performed in outpatient settings. that non-triple-negative cancers are predominantly hypoechoic strongly correlate...