A5009714246- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Electrochemical Analysis and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Nanopore and Nanochannel Transport Studies
- Covalent Organic Framework Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Carbon and Quantum Dots Applications
- Luminescence and Fluorescent Materials
- Glioma Diagnosis and Treatment
- biodegradable polymer synthesis and properties
- Tryptophan and brain disorders
- Iron Metabolism and Disorders
- Barrier Structure and Function Studies
- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- Brain Metastases and Treatment
- Digital Imaging for Blood Diseases
- Meningioma and schwannoma management
- Natural Fiber Reinforced Composites
- Neuroscience and Neural Engineering
Quaid-i-Azam University
2024
Hainan Medical University
2024
Henan University
2019-2022
Nanjing University
2017-2020
State Key Laboratory of Pharmaceutical Biotechnology
2017
Walton Centre
2014
University of Liverpool
2014
Abstract Defect engineering is an emerging technology for tailoring nanomaterials' characteristics and catalytic performance in various applications. Recently, defect‐engineered nanoparticles have emerged as highly researched materials applications because of their exceptional redox reaction capabilities physicochemical optical properties. The properties nanomaterials can be readily adjusted by controlling the nature concentration defects within nanoparticles, avoiding need intricate design...
It is challenging to develop a robust nanoprobe for real-time operational and accurate detection of heavy metals in single cells. Fe-CN coordination chemistry has been well studied determine the structural characteristics hemeproteins by different techniques. However, frequently used cyanide ligands are inorganic molecules that release anion under particular conditions cause poisoning. In present study, organic (4-mercaptobenzonitrile, MBN) was utilized first time developing facile based on...
A crack-free sub-nanometer composite structure for the study of ion transfer was constructed by in situ growth ZIF-90 [Zn(ICA)2 , ICA=Imidazole-2-carboxaldehyde] on tip a glass nanopipette. The potential-driven through channels is strongly influenced pH solution. rectification ratio over 500 observed 1 m KCl solution under alkaline conditions (pH 11.58), which highest value reported such high salt concentration. Fluorescence experiments show super-high results from strong electrostatic...
Single cell analysis is essential for understanding the heterogeneity, behaviors of cells, and diversity target analyte in different subcellular regions. Nucleolin (NCL) a multifunctional protein that markedly overexpressed most cancer cells. The variant expression levels NCL regions have marked influence on proliferation treatments. However, specificity available methods to identify biomarkers limited because high level matrix effect. Herein, we proposed novel technique increase both...
Nanopore structures have been successfully employed in next-generation DNA sequencing. For more complicated protein which normally contains 20 different amino acids, identifying the fluctuation of ionic current caused by acids appears inadequate for Therefore, it is highly desirable to develop size-controllable nanopores with optical activity that can provide additional structural information. Herein, we discovered novel nanopore properties self-assembled ultramicroelectrodes originally...
Layered/two-dimensional covalent organic frameworks (2D COF) are crystalline porous materials composed of light elements linked by strong bonds. Interlayer force is one the main factors directing formation a stacked layer structure, which plays vital role in stability, crystallinity, and porosity layered COFs. The as-developed new way to modulate interlayer imine-linked 2D TAPB-PDA-COF (TAPB = 1,3,5-tris(4-aminophenyl)benzene, PDA terephthaldehyde) only adjusting pH solution. At alkaline...
Central nervous system (CNS) disorders feature the progressive and selective loss of normal brain functions. CNS often include an irreversible physiological anatomical neurons that can lead to dysfunction in various parts eventually death. Glioblastoma multiforme (GBM) neurodegenerative diseases such as Alzheimer's disease (AD) Parkinson's (PD) are hard be diagnosed at early stage for prevention propagation. Such diagnosis is vital timely commencement actual treatments. Nanotechnology brings...
Background: DKA, a severe diabetes complication, is increasing, especially in low-income nations like Pakistan. Quetta lacks data on its local impact. Objective: To determine DKA prevalence adults, analyze clinical signs, risk factors, and demographics, improving understanding of the condition. Methods: 230 adult patients (≥18 years) with diagnosis diabetic ketoacidosis participated descriptive, cross-sectional study at tertiary care hospital. Purposive sampling was used to choose based...
Background: In critically sick patients, especially those hospitalized to intensive care units (ICUs), acute kidney damage (AKI) is a serious consequence. It distinguished by an abrupt deterioration in renal function, which raises morbidity and mortality. Because of its high prevalence dismal prognosis, AKI continues be significant issue despite improvements critical care. Objective: The objective this study identify the risk factors frequency patients unit. focusses on determining main...
Abstract A crack‐free sub‐nanometer composite structure for the study of ion transfer was constructed by in situ growth ZIF‐90 [Zn(ICA) 2 , ICA=Imidazole‐2‐carboxaldehyde] on tip a glass nanopipette. The potential‐driven through channels is strongly influenced pH solution. rectification ratio over 500 observed 1 m KCl solution under alkaline conditions (pH 11.58), which highest value reported such high salt concentration. Fluorescence experiments show super‐high results from strong...
Glioblastoma (GBM) has a distinct internal environment characterized by high levels of glutathione (GSH) and low oxygen partial pressure, which significantly restrict most drugs’ effectiveness. Arsenic-based drugs are emerging candidates for treating solid tumors; however, relatively doses in solo systems inconsistent complementary severely damage the normal tissues. We proposed novel covalently conjugated strategy arsenic-based therapy via arsenic-boronic acid complex formation. The boronic...
Abstract Background Glioblastoma multiforme (GBM) is one of the most daunting issues to modern therapeutics, with a higher mortality rate post-diagnosis. Temozolomide (TMZ) only available treatment; however, frequent resistance leaves oncologists at dead end. Therefore, new approaches circumvent GBM are highly desired. We have employed TiO 2 nanosticks loaded TMZ as nanomedicine for TMZ-resistant resection in this contribution. Results The ultrasonication triple-action effect could greatly...
A novel multimodal anemia diagnosis assay was developed using the SERS and compared with routinely used clinical assays. The dual-target (iron ion/metalloprotein) capturing efficiency<italic>via</italic>strong organic cyanide affinity utilized for whole blood analyses.
Covalent organic frameworks (COFs) consist nanochannels that are fundamentally important for their application. Up to now, the effect of gas phase on COF hard explore. Here, TAPB-PDA-COFs (triphenylbenzene-terephthaldehyde-COFs) was synthesized in situ at tip a theta micropipette. The COF-covered micropipette (CTP) create stable gas–liquid interface inside nanochannels, through which humidity-modulated ion mass transfer can be recorded by recording current across two channels Results show...
Green fabrication of nanoscale materials is highly desirable because associated adverse effects with conventional nanomaterial biomedical applications. Moreover, the higher selective nature blood-brain barrier (BBB) limits brain ailments treatment through chemotherapy, thus providing room for nanotechnology-based modalities BBB traversing. In this contribution, we have biosynthesized gold nanoparticles from HAuCl
INTRODUCTION: Astrocytomas WHO grade II (AII) are diffusely infiltrating tumours whose management is challenging with the role of biopsy vs. resection and timing oncology therapy remaining controversial. The aim this single-institution study was to review clinical outcome for patients AII diagnosed between 2006 2012. METHOD: Adult newly-diagnosed were identified from histopathology records case notes reviewed. Data analysis used SPSS. RESULTS: 92 identified: median age 42 (20-73), follow-up...