A5102006532- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Blood Coagulation and Thrombosis Mechanisms
- Neonatal Respiratory Health Research
- Prenatal Substance Exposure Effects
- Cancer, Lipids, and Metabolism
- Cardiovascular Issues in Pregnancy
- Preterm Birth and Chorioamnionitis
- Hormonal Regulation and Hypertension
- Infant Development and Preterm Care
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and Medication Impact
- Fatty Acid Research and Health
- Gestational Diabetes Research and Management
- Uterine Myomas and Treatments
- Liver Disease and Transplantation
- Opioid Use Disorder Treatment
- Cardiac Imaging and Diagnostics
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Emergency and Acute Care Studies
- Infant Nutrition and Health
- Pregnancy-related medical research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pelvic floor disorders treatments
- Renin-Angiotensin System Studies
University of Kentucky
2018-2024
St. John Hospital & Medical Center
2014-2016
Johnson University
2016
Rutgers, The State University of New Jersey
2016
Hypertension during pregnancy increases the risk of adverse maternal and fetal outcomes, but mechanisms hypertension are not precisely understood. Elevated plasma renin activity aldosterone concentrations play an important role in normal physiologic adaptation to pregnancy. These effectors reduced patients with hypertension, creating opportunity define features renin-angiotensin-aldosterone system (RAAS) that characteristic this disorder. In current study, we used a novel LC-MS/MS-based...
Women exposed to phthalates during pregnancy are at increased risk for delivering preterm, but the mechanism behind this relationship is unknown. Placental corticotropin-releasing hormone (CRH) and cyclooxygenase-2 (COX-2) key mediators of parturition regulated by non-canonical NF-kB (RelB/p52) signaling pathway. In study, we demonstrate that one major phthalate metabolites, mono-(2-ethylhexyl)-phthalate (MEHP), CRH COX-2 mRNA protein abundance in a dose-dependent manner primary cultures...
Emerging evidence indicates a previously unrecognized, clinically relevant spectrum of abnormal aldosterone secretion associated with hypertension severity. It is not known whether excess contributes to during pregnancy. We quantified concentrations and angiotensin peptides in serum (using liquid chromatography tandem mass spectrometry) cohort 128 pregnant women recruited from high-risk obstetrics clinic followed prospectively for the development gestational hypertension, pre-eclampsia,...
Background. Ectopic pregnancy is one of the leading causes significant maternal morbidity and mortality. Abdominal surgeries increase risk postoperative adhesions. We here present a case omental ectopic in patient with prior history cesarean section. Case. A 20-year-old female presented two-day crampy lower abdominal pain. Patient was hemodynamically stable beta HCG 1057 mI/mL. Transvaginal ultrasound did not show an intrauterine but revealed ill-defined mass midline pelvis extending to...
Objective: To determine if a structured care-by-parent (CBP) protocol is associated with reduction in diagnosis of treatment-requiring Neonatal Opioid Withdrawal Syndrome (NOWS).Study design: We performed pilot retrospective, case control study pregnant women enrolled comprehensive prenatal care program for opioid-dependent patients during which they received buprenorphine Medication Assisted Treatment (MAT) Use Disorder (OUD). Patients who participated the CBP actively roomed-in their...
INTRODUCTION: Splenic artery aneurysm (SAA) is the third most common intraabdominal aneurysm. rupture a rare, but life-threatening complication of pregnancy. We present case splenic in labor where prompt diagnosis with multidisciplinary intervention resulted favorable maternal and fetal outcome. METHODS: A 24-year-old woman, gravida 1 para 0 at 39 weeks gestation presented to delivery unit for scheduled induction gestational hypertension. During course labor, patient had an abrupt onset...
INTRODUCTION: This study was undertaken to evaluate the relationship between pre-pregnancy body mass index (PPBMI), gestational weight gain (GWG) and fetal macrosomia. METHODS: Vital statistics (birth) data collected by National Center for Health Statistics (NCHS) utilized. Using 2015 data, GWG calculated birth cohort consisting of singleton gestations classified into inadequate, adequate excess categories under each PPBMI stratum, as per 2009 Institute Medicine guidelines. Multivariate...
INTRODUCTION: To determine a relationship between the timing of buprenorphine dosing to delivery and subsequent Neonatal Opioid Withdrawal Syndrome (NOWS). METHODS: This was pilot retrospective cohort study. Pregnant women with opioid use disorder (OUD) on maintenance therapy (OMT) through perinatal OUD treatment program (PATHways) were enrolled. Prior PATHways data revealed improved neonatal outcomes in mean 12 mg/day.12 mg utilized as cut point for high vs low dose. High dose cases 16...
INTRODUCTION: To determine if cervical cerclage placement plus vaginal progesterone for short cervix decreased the risk preterm birth in singleton gestations without prior spontaneous birth. METHODS: This was a retrospective cohort study. Electronic charts of patients with between 2007-2017 at University Kentucky were reviewed. Those length <25 mm 16 0/7 and 23 6/7 weeks gestation eligible. All women received progesterone. A subgroup also undergoing compared to those on alone. receiving...
Abstract Hypertension during pregnancy increases the risk for adverse maternal and fetal outcomes, but mechanisms of hypertension are not precisely understood. Elevated plasma renin activity aldosterone concentrations play an important role in normal physiologic adaptation to pregnancy. These effectors reduced patients with hypertension, creating opportunity define features renin-angiotensin-aldosterone system (RAAS) that characteristic this disorder. In current study, we used a novel...