In Tanzania, the impact, on clinical outcomes and treatment-seeking behaviour, of a rural, nurse-led clinic that provides free, antivenom-based treatment snakebite envenomation was recently assessed. Data all 85 patients who, between April 2007 end 2009, received for at Snake Park in Meserani, were collected prospectively. Although only four cases treated last 9 months 2007, 34 such 2008 47 2009. The had mean age 23 years male:female ratio 1.4. Most bites occurred evening or night most also...

There are no demographic data published on those with viral infections of the pubis (VIPs). We conducted a two-year prospective study to collect information patients VIPs. Data were gathered age, sex, diagnosis, low (≤10) or high (>10) lesion number, symptoms, how patient discovered lesions, localization, lesions beyond pubis, risk factors, shaving habits, human papillomavirus (HPV) vaccination status and treatment. In total 61 patients, molluscum contagiosum (MC) was identified in 71%,...

Locally advanced basal cell carcinoma (laBCC) represents approximatively 1% of all BCCs. Metastatic BCC (mBCC) is even more rare. Most cases are observed in immunocompromised patients, particularly solid organ transplant recipients (OTRs). When surgery and/or radiation therapy for laBCC or mBCC not reasonable, oral hedgehog inhibitor (HHI) may be initiated. LaBCC patients with primary secondary resistance, progression intolerance to HHIs could benefit from programmed death protein-1 (PD-1)...

Mycosis fungoides (MF) is the most frequent type of primary cutaneous T-cell/NK-cell lymphoma. The Koebner phenomenon defined as appearance lesions on previously noninvolved skin following trauma and observed in a series diseases including psoriasis, lichen planus, viral warts, molluscum contagiosum, etc. In this case report, 3 patients with longstanding MF are presented, 1st circumscribed early-stage lesion rapidly surgical excision an infundibular cyst, 2nd unique unilateral palmar tumoral...

<b><i>Background:</i></b> Mycosis fungoides (MF) is the most frequent type of primary cutaneous natural killer and T-cell lymphoma. MF-required immunosuppressive therapies MF-related characteristics render patients with MF more prone to infections. <b><i>Aim:</i></b> To describe clinical features infections observed in patients. <b><i>Materials Methods:</i></b> A series 56 were followed prospectively over 3 years...

BRAF inhibitors may present several cutaneous adverse effects, including actinic keratosis, squamous cell carcinoma, keratoacanthoma, rashes, increased photosensitivity, panniculitis, palmoplantar and capillary involvement, pruritus xerosis as well granulomatous reactions. A 30-year-old patient with multiple tattoos received dabrafenib trametinib for metastatic melanoma. After 4 months, he developed an induration thickening strictly limited to tattoos. Histopathology revealed nonnecrotizing...

Basal cell carcinoma of the umbilicus is very rare. The nodular subtype main representative. Giant basal carcinomas represent around 1% all carcinomas. hedgehog pathway inhibitor vismodegib indicated for advanced and CD56-negative immunostaining seems indicative successful treatment. A 54-year-old man presented a 10 cm × 14 large 4.5 deep morphea-form with faint immunohistochemical CD56 expression arising from umbilicus. sequential treatment was initiated debulking using 150 mg per day 4...

Abstract Scabies is a very common ectoparasitosis and responsible for real scourge worldwide. The infestation leads to highly contagious pruritic dermatosis. Clinical diagnosis not always easy; dermoscopy useful diagnostic tool. Treatment relies on hygienic measures specific acaricidals, either topical application or oral administration. Ivermectin, permethrin benzyl benzoate are the most frequently used therapies. failure rise could be attributed noncompliance, treatment costs resistance...

<b><i>Background:</i></b> The advancing evolution toward a Th2 immune environment confers progressive immunosuppression in patients with longstanding cutaneous T-cell lymphoma (CTCL). conjunction of the disease-related as well immunosuppressive character some CTCL treatments increase risk infectious and neoplastic diseases, sometimes fatal outcomes. <b><i>Objectives:</i></b> aim study was to prospectively causes death cohort patients, tertiary...

Locally advanced cutaneous squamous cell carcinoma (lacSCC) is rare. Approximately one-fourth of the cases are observed among immunocompromised patients, in particular solid organ transplant recipients (OTRs). LacSCC has a very poor prognosis. Surgery with or without radiotherapy remains golden standard treatment for cSCC. However, cases, there medical need alternative options. Classic systemic treatments include chemotherapy and/or EGFR inhibitors. Recently effectiveness programmed death...

Eruptive seborrheic keratoses (ESK) are rare in dermatology. They usually inflammatory nature and may be encountered as Leser-Trélat sign. ESK also simultaneously observed with hepatic angiomas, chemotherapy, segmental neurofibromatosis, HIV or erythrodermic pityriasis rubra pilaris, psoriasis, drug eruption. transient self-healing. Others recede after successful treatment of the underlying disease. In some instances, follow an isotopic response remain strictly restricted to sites previous...

Cutaneous metastases of breast cancer remain a therapeutic challenge. Oxygen flow-assisted topical administration methotrexate 5% (OFAMTX, in carrier solution) has recently been proven to be an efficacious alternative treatment for extramammary Paget's disease, which is considered situ mammary adenocarcinoma the epidermis. A 51-year-old patient with triple negative presenting biopsy-proven skin on chest agreed OFAMTX5%. The duration was 2 weeks and consisted twice-weekly sessions OFAMTX5%...

Abstract Background The International Alliance for the Control of Scabies (IACS) recently published expert consensus criteria scabies diagnosis. Formal validation these is needed to guide implementation. We conducted a study provide detailed description morphology and distribution lesions as assessed by dermatologists validate IACS diagnosis both non-expert examiners. Methods Participants from community in Monrovia, Liberia, were independently two six mid-level healthcare workers. Lesion...

Introduction Psoriasis affects around 2% of children in Europe. The majority cases is readily managed with topical treatments using corticosteroids without or calcipotriol. More resistant and extensive moderate-to-severe require UVA UVB phototherapies conventional systemic treatment including ciclosporin, acitretin methotrexate. However, these therapies are associated a low tolerability potential cumulative long-term adverse effects toxicities.Areas covered About 15 years ago, the first...

Background: Mycosis Fungoides (MF) is the most frequent type of primary cutaneous NK/T-cell lymphomas. Ingenol mebutate (IM) displays in vitro pro-apoptotic properties on neoplastic lymphocytes. Objectives: To evaluate efficacy and safety IM gel as topical treatment for MF. Materials Methods: Ten male patients with longstanding classic MF (n=9) follicular (FMF; n=1), T2bN0M0B0, stage Ib, resistant to systemic methotrexate or acitretin therapies at least 3 months, were included this pilot...

Pachyderma is defined as severely thickened skin with deep folds and occasionally observed primary cutaneous NK T-cell lymphoma (pCNKTCL), B-cell (pCBCL), leukemia cutis (LC).To describe the clinical, histological, therapeutic particularities of a series pCNKTCL, pCBCL, LC patients pachyderma.In pCNKTCL (n = 70), pCBCL 12), 2) followed up during 9 years, 6 cases pachyderma were observed. occurred on arms 2), thighs 1), forehead face 2). The mean age was 69 years (51-82). stages erythrodermic...