A5058132033- Cutaneous Melanoma Detection and Management
- Nail Diseases and Treatments
- Skin Protection and Aging
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Cancer and Skin Lesions
- Dermatological and Skeletal Disorders
- Genetic and rare skin diseases.
- Skin and Cellular Biology Research
- Fungal Infections and Studies
- Cancer Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Skin Diseases and Diabetes
- Dermatologic Treatments and Research
- Advancements in Transdermal Drug Delivery
- Antifungal resistance and susceptibility
- Contact Dermatitis and Allergies
- Infectious Diseases and Mycology
- Chemotherapy-related skin toxicity
- Plant Pathogens and Fungal Diseases
- Diagnosis and Treatment of Venous Diseases
- Vascular Tumors and Angiosarcomas
Centre Hospitalier Universitaire de Liège
2012-2023
University of Liège
2014-2023
Centre Hospitalier Régional de Huy
2003-2012
Weatherford College
2008-2011
Fonds National de la Recherche
2005-2010
In-Q-Tel
2005
Institut Paoli-Calmettes
2002
Institut Pprime
2002
We performed this study in order to evaluate the diagnostic accuracy of whole-body fluorodeoxyglucose positron emission tomography (FDG PET) imaging and somatostatin receptor scintigraphy (SRS) for localizing primary carcinoid tumours evaluating extent disease. A secondary aim was correlate those findings with histological characteristics lesions. FDG PET 17 patients SRS 16. All had pathologically proven carcinoids. lesions were verified by histopathological analysis or follow-up. Ki-67 p53...
A 30-year-old man who presented with delayed puberty and infertility was found to have hypogonadism associated an absence of circulating luteinizing hormone. The patient had a homozygous missense mutation in the gene that encodes beta subunit hormone (Gly36Asp), disrupted vital cystine knot motif abrogated heterodimerization secretion Treatment human chorionic gonadotropin increased testosterone, promoted virilization, appearance normal spermatozoa low concentrations. This case illustrates...
Cellulite, sometimes called gynoid lipodystrophy, is much more prevalent in women than men. There are glaring discrepancies regarding the microanatomical descriptions of this condition literature. A lumpy aspect dermo-hypodermal interface often cited, but it appears to represent a gender-linked characteristic thighs and buttocks without being specific sign cellulite. Incipient cellulite recognized by discrete padded look or 'orange peel' correlated with presence network focally enlarged...
Wrinkles result from distinct structural changes occurring in specific parts of the dermis and subcutaneous tissue. There is a need for evidenced-based cosmetology identifying quantifying different aspects wrinkling. Histology allows to detect associated with particular types wrinkles. Four main wrinkles can thus be recognized, including atrophic crinkling rhytids, permanent elastotic creases, dynamic expression lines, gravitational folds. Each type usually develops on skin regions...
Myxofibrosarcoma (MFS) is a variant of the group malignant fibrous histiocytomas. It one most aggressive types soft tissue neoplasms. The clinical presentation not pathognomonic and histological aspects are highly heterogenous, frequently delaying diagnosis or leading to misdiagnosis. Complementary histochemical immunohistochemical stainings mandatory achieve MFS. A 78-year-old male patient presented illustrating this diagnostic pitfall. Extensive surgery followed by radiotherapy first...
AIMS: To study the cutaneous and visceral distribution of herpes simplex virus (HSV) varicella zoster (VZV) in fatal infections. METHODS: Standard histology, immunohistochemistry (monoclonal antibodies VL8 VL2 polyclonal antibody IE63 directed against VZV; monoclonal IBD4 HH2 HSVI HSVII) situ hybridisation (anti-HSV anti-VZV probes) were applied to formalin fixed, paraffin wax sections. RESULTS: On histological examination, Herpesviridae infection was evident various organs including lungs,...
Pemetrexed (Alimta®) is a multitargeted antifolate drug approved as single agent or in combination with cisplatin for the treatment of small number malignancies including advanced and metastatic non-squamous non-small cell lung cancer (NSCLC), malignant pleural mesothelioma. This review reports recent peer-reviewed publications original findings regarding cutaneous adverse reactions (CARs) to pemetrexed. Pemetrexed-related CARs are frequently reported under unspecific term ‘skin rash’....
The incidence of syphilis is increasing in most parts the world including some major European cities. lesions developing during secondary may be difficult to diagnose clinically. Similarly, histopathologic changes do not always fulfill typical diagnostic criteria. objective this study was assess contribution immunohistochemistry for identification and localization Treponema pallidum on skin. We retrieved from our files 12 paraffin-embedded biopsies skin lesions, which had posed problems...
Background: Skin aging is a multifaceted process influenced by various factors affecting at variable degree different body sites. This study focused on the dermal dendrocytes and microvasculature. We also explored effect of substance P released capsaicin because this neuropeptide known to affect microvasculature environment. Methods: The first part present was undertaken in two groups 35 men who were younger than 30 years older 65 years, respectively. A skin biopsy taken from intact thigh...
Increased awareness among dermatologists as well the development of dermoscopy and sequential have contributed significantly toward an increase in diagnostic accuracy pigmented melanoma even amelanotic melanoma. However, dermatologist's nightmare is small group melanomas that present common skin diseases, often associated with a significant delay diagnosis hence poor prognosis. The study was carried out to prospectively assess number lacking any clinical suspicion describe their histological...
The human dermis contains a series of dendritic cells which express different phenotypes including Factor XIIIa immunoreactivity. This compound is related to blood coagulation factor participating in angiogenesis, the final stages clotting cascade and wound healing. In normal skin, expressed specific dermal dendrocytes (DD) derived from monocyte/macrophage lineage or mesenchymal origin. DD are located predominantly around microvasculature adventitial dermis, at dermo-epidermal junction, skin...
Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis. The various cytokines identified in experimental also present ulcers. VEGF strongly implicated as promoter of blood vessel growth patients with venous disease. In addition, there good evidence increased expression bFGF, TGF-beta1, PDGF lipodermatosclerosis. All these factors involved wound...
Preterm premature rupture of membranes (PPROM) likely results from weakening the constituent connective tissue. It is uncertain if alterations are limited to fetal or also present in other sites such as skin. The aim study was compare dermal structure women suffering recurrent PPROM with dermis both non-pregnant and uneventful gestation. Skin biopsies were taken 42 who recently underwent PPROM, 33 gestation women. Histochemistry, immunohistochemistry, electron microscopy performed on these...
Abstract: Human intravenous immunoglobulins (IVIg) which contain anti‐CD95 antibodies have been proposed to treat toxic epidermal necrolysis (TEN). Presently, there is no evidence that IVIg reach the keratinocytes in TEN patients. The aim of this study was assess Ig distribution serum, blister fluid and skin six consecutive patients treated with (1 g/kg/day) for 3 days. They were compared five who only received supportive therapy. In all patients, IgA, IgM IgG concentrations measured serum...
Background: Scarring is a complex process involving many cell types, cytokines and biological pathways including mechanobiology. Some subtle mechanical properties of skin can be assessed by measuring the speed ultrasound shear wave propagation. The orientation abnormal tension forces visualized, particularly in darker using dermoscopy showing distinct patterns rete ridges' conformation. Aim: To assess some mechanobiological features scars types. Patients methods: Large atrophic hypertrophic...