A5065486343- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Inflammation biomarkers and pathways
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Extracellular vesicles in disease
- Neonatal Respiratory Health Research
- S100 Proteins and Annexins
- Influenza Virus Research Studies
- Nanoplatforms for cancer theranostics
- Nitric Oxide and Endothelin Effects
- COVID-19 Clinical Research Studies
- Mast cells and histamine
- Phagocytosis and Immune Regulation
- Genetic Associations and Epidemiology
- Antifungal resistance and susceptibility
- Liver Disease Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Pancreatitis Pathology and Treatment
University of Liège
2015-2024
Fonds National de la Recherche
2024
Fund for Scientific Research
2024
Laboratory of Molecular Genetics
2024
Infection with SARS-CoV-2 is causing a deadly and pandemic disease called coronavirus disease–19 (COVID-19). While SARS-CoV-2–triggered hyperinflammatory tissue-damaging immunothrombotic responses are thought to be major causes of respiratory failure death, how they relate lung immunopathological changes remains unclear. Neutrophil extracellular traps (NETs) can contribute inflammation-associated damage, thrombosis, fibrosis. However, whether NETs infiltrate particular compartments in severe...
Abstract Resident tissue macrophages (RTM) can fulfill various tasks during development, homeostasis, inflammation and repair. In the lung, non-alveolar RTM, called interstitial (IM), importantly contribute to homeostasis but remain little characterized. Here we show, using single-cell RNA-sequencing (scRNA-seq), two phenotypically distinct subpopulations of long-lived monocyte-derived IM, i.e. CD206 + − as well a discrete population extravasating CD64 CD16.2 monocytes. IM are peribronchial...
High-mobility group box 1 (HMGB1) is a multifunctional redox-sensitive protein involved in various intracellular (eg, chromatin remodeling, transcription, autophagy) and extracellular (inflammation, autoimmunity) processes. Regarding its role cancer development/progression, paradoxical results exist the literature it still unclear whether HMGB1 mainly acts as an oncogene or tumor suppressor.
Abstract Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and exert important tissue-supportive functions. RTM maintenance is thought to rely either on differentiation from monocytes or self-renewal. Here, we used a mouse model of inducible lung interstitial macrophage (IM) niche depletion refilling investigate the development IMs in vivo. Using time-course single-cell RNA-sequencing analyses, bone marrow chimeras gene targeting, found...
Lung macrophages constitute a sophisticated surveillance and defense system that contributes to tissue homeostasis, host defense, allows the cope with myriad of insults antigens which lung mucosa is exposed. As opposed alveolar macrophages, interstitial express high levels type 2 major histocompatibility complex (MHC-II), hallmark antigen-presenting cells. Here, we showed IMs, like dendritic cells (DCs), possess machinery present soluble in an MHC-II-restricted way. Using ex vivo ovalbumin...
The lung is constantly exposed to airborne pathogens and particles that can cause alveolar damage. Hence, appropriate repair responses are essential for gas exchange life. Here, we deciphered the spatiotemporal trajectory function of an atypical population macrophages after injury. Post-influenza A virus (IAV) infection, short-lived monocyte-derived Ly6G-expressing (Ly6G
Asthma encompasses a spectrum of heterogenous immune-mediated respiratory disorders sharing similar clinical pattern characterized by cough, wheeze and exercise intolerance. In horses, equine asthma can be subdivided into severe or moderate according to symptoms the extent airway neutrophilic inflammation. While asthmatic horses are an elevated inflammation lower airways, dyspnea at rest high mucus secretion, with show milder inflammation, exhibit intolerance but no labored breathing rest....
Background Air pollution, including particulates and gazes such as ozone (O 3 ), is detrimental for patient’s health has repeatedly been correlated to increased morbidity mortality in industrialised countries. Although studies have described a link between ambient particulate matter lung cancer morbidity, no direct relation yet established O exposure metastatic dissemination lungs. Objectives To outline the mechanisms through which pulmonary modulates metastasis kinetics an experimental...
Neutrophils are one of the first innate immune cells recruited to tissues during inflammation. An important function neutrophils relies on their ability release extracellular structures, known as Neutrophil Extracellular Traps or NETs, into environment. Detecting such NETs in humans has often proven challenging for both biological fluids and tissues; however, this can be achieved by quantitating NET components (e.g., DNA granule/histone proteins) directly visualizing them microscopy,...
<b>Introduction:</b> To ensure appropriate responses to foreign components present in the environment, lung is endowed with an important network of immune cells. Among these cells, macrophages are tissue-resident phagocytes that play essential role onset and regulation responses. If alveolar (AMs) were described decades ago, last few years have seen outcome a new understanding their ontogeny but also characterization macrophage subset, interstitial (IMs). These discoveries highlight...