A5051690225- Estrogen and related hormone effects
- Angiogenesis and VEGF in Cancer
- Neuroendocrine regulation and behavior
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Neonatal Respiratory Health Research
- Cytokine Signaling Pathways and Interactions
- Electrolyte and hormonal disorders
- Menopause: Health Impacts and Treatments
- Immune cells in cancer
- Analytical Chemistry and Chromatography
- Neuropeptides and Animal Physiology
- Cancer, Stress, Anesthesia, and Immune Response
- Lymphatic System and Diseases
- Stress Responses and Cortisol
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Breast Cancer Therapies
- Phytoestrogen effects and research
University of Liège
2015-2024
Université Toulouse III - Paul Sabatier
2012
École Nationale Vétérinaire de Toulouse
2012
Institut Claudius Regaud
2012
Inserm
2012
Centre hospitalier régional de la Citadelle
2010
Centre Hospitalier Chrétien
2009
Cancer-associated fibroblasts (CAFs) are key actors in modulating the progression of many solid tumors such as breast cancer (BC). Herein, we identify an integrin α11/PDGFRβ+ CAF subset displaying tumor-promoting features BC. In preclinical MMTV-PyMT mouse model, α11-deficiency led to a drastic reduction tumor and metastasis. A clear association between α11 PDGFRβ was found at both transcriptional histological levels BC specimens. High stromal α11/PDGFRβ expression associated with high...
Successful embryo development requires an extensive endometrial angiogenesis in proximity of implantation site. The glycoprotein hCG is produced even before by trophoblast normal pregnancy. In this manuscript, we demonstrate angiogenic effect several vivo (chick chorioallantoïc membrane, matrigel plug assay, aortic ring assay) and vitro experimental models. contrast, human placental lactogen (hPL) did not display properties. LH/hCG receptor was detected endothelial cells...
Pre-eclampsia is a pregnancy disorder characterized by maternal endothelial cell dysfunction associated with low levels of circulating placental growth factor (PlGF) and increased total vascular (VEGF), soluble VEGF receptor-1 (sVEGFR-1), endoglin, transforming β1 3 coreceptor. Here, we tested the hypothesis that these altered angiogenic cytokines anti-angiogenic forms cytokine receptors could be consequence hypoxia. Normal human umbilical vein cells, immortalized first trimester...
Estrogens directly promote the growth of breast cancers that express estrogen receptor α (ERα). However, contribution stromal expression ERα in tumor microenvironment to protumoral effects has never been explored. In this study, we evaluated molecular and cellular mechanisms by which 17β-estradiol (E2) impacts modulates development ERα-negative tumors. Using different mouse models ER-negative cancer cells grafted subcutaneously into syngeneic ovariectomized immunocompetent mice, found E2...
Context: During the periimplantation period, human chorionic gonadotropin (hCG) plays a key role by increasing uterine blood flow through vessel vasodilatation but also angiogenesis. Indeed, we previously demonstrated that hCG contributes to endothelial cell recruitment and formation. Objective: In this study, was proposed as an arteriogenic factor could promote perivascular stabilization. Design: The aortic ring assay, three-dimensional ex vivo angiogenesis system mimicking all steps of...
Estetrol (E 4 ) is a natural estrogen produced exclusively by the human fetal liver during pregnancy. Its physiological activity remains unknown. In contrast to ethinyl estradiol and 2 ), E has minimal impact on cell could provide better safety profile in contraception or hormone therapy. The aim of this study was delineate if exhibits an distinct from that mammary gland. Compared with , acted as low-affinity both vitro murine vivo models. 100 times less potent than stimulate proliferation...
Malignant growth of small-cell lung carcinoma is promoted by various neuroendocrine autocrine/paracrine loops. Therefore, to interfere with this mitogenic process, it crucial elucidate the mechanisms involved. It known that oxytocin (OT) and vasopressin (VP) genes, normally transcriptionally restricted in their expression, are activated cancer (SCLC), concomitantly expression receptors (OTR, V1aR, V1bR/V3R V2R). The aim present study was characterize, concentrations close physiological...
// Céline Gérard 1 , Mélanie Mestdagt Ekaterine Tskitishvili Laudine Communal 2 Anne Gompel 2,3 Elisabete Silva 4 Jean-François Arnal 5 Françoise Lenfant Agnès Noel Jean-Michel Foidart and Christel Péqueux Laboratory of Tumor Development Biology, GIGA-Cancer, University Liège, Belgium Gynaecological Endocrinology Unit, Paris Descartes University, Hôpitaux Universitaires, Paris, France 3 INSERM U 938, UPMC, Institute Environment, Health Societies, Brunel London, UB83PH Uxbridge, United...
It is now well accepted that multipotent Bone-Marrow Mesenchymal Stem Cells (BM-MSC) contribute to cancer progression through several mechanisms including angiogenesis. However, their involvement during the lymphangiogenic process poorly described. Using BM-MSC isolated from mice of two different backgrounds, we demonstrate a paracrine action both in vivo and vitro. Co-injection tumor cells increased growth intratumoral lymphatic vessel density. In addition, or conditioned medium stimulated...
Background Air pollution, including particulates and gazes such as ozone (O 3 ), is detrimental for patient’s health has repeatedly been correlated to increased morbidity mortality in industrialised countries. Although studies have described a link between ambient particulate matter lung cancer morbidity, no direct relation yet established O exposure metastatic dissemination lungs. Objectives To outline the mechanisms through which pulmonary modulates metastasis kinetics an experimental...
Background Several studies have suggested that the main features of preeclampsia (PE) are consequences endothelial dysfunction related to excess circulating anti-angiogenic factors, most notably, soluble sVEGFR-1 (also known as sFlt-1) and endoglin (sEng), well decreased PlGF. Recently, VEGF type 2 receptor (sVEGFR-2) has emerged a crucial regulator lymphangiogenesis. To date, however, there is paucity information on changes VEGFR-2 occur during clinical onset PE. Therefore, aim our study...
Abstract The assessment of rodent mammary gland morphology is largely used to study the molecular mechanisms driving breast development and analyze impact various endocrine disruptors with putative pathological implications. In this work, we propose a methodology relying on fully automated digital image analysis methods including processing quantification whole ductal tree terminal end buds as well. It allows accurately objectively measure both growth parameters fine morphological glandular...
Given the unequivocal benefits of menopause hormone therapies (MHT) and combined oral contraceptives (COC), there is a clinical need for new formulations devoid any risk breast cancer promotion. Accumulating data from preclinical studies support that estetrol (E4) promising natural estrogen MHT COC. Nevertheless, we report here E4 remains active on endometrium, even under dose neutral growth lung metastasis dissemination. This implies progestogen should be with to protect endometrium...