A5008019167- Diabetes and associated disorders
- Growth Hormone and Insulin-like Growth Factors
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Neuroendocrine regulation and behavior
- Adrenal Hormones and Disorders
- Neuropeptides and Animal Physiology
- Immunodeficiency and Autoimmune Disorders
- Myasthenia Gravis and Thymoma
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Immune Response and Inflammation
- Frailty in Older Adults
- Nutrition and Health in Aging
- Reproductive System and Pregnancy
- Organic Chemistry Cycloaddition Reactions
- Viral Infections and Immunology Research
- Fluorine in Organic Chemistry
- Synthesis and Reactions of Organic Compounds
- Inorganic and Organometallic Chemistry
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Advanced NMR Techniques and Applications
- Synthetic Organic Chemistry Methods
University of Liège
2012-2021
Institute of Immunology
2008-2012
Centre Hospitalier Universitaire de Liège
2007
Freie Universität Berlin
2006
Landesamt für Kultur und Denkmalpflege Mecklenburg-Vorpommern
2000-2001
Kiel University
1993
Transnational University Limburg
1981-1992
Service de la Santé Publique
1990
KU Leuven
1970-1975
University of Veterinary Medicine Hannover, Foundation
1973
Resistance to glucocorticoid therapy has been observed in patients with autoimmune/inflammatory diseases and may be related the inflammatory process itself. The aim of this study was examine ability tumor necrosis factor α (TNFα, a proinflammatory cytokine) interleukin (IL)-10 (an anti-inflammatory differentially regulate sensitivity human monocytes/macrophages glucocorticoids. To accomplish this, we first analyzed pattern TNFα IL-10 inhibition by dexamethasone LPS-stimulated whole-blood...
Patients with Prader-Willi syndrome (PWS) display poor feeding and social skills as infants fewer hypothalamic oxytocin (OXT)-producing neurons were documented in adults. Animal data demonstrated that early treatment OXT restores sucking after birth. Our aim is to reproduce these PWS.We conducted a phase 2 escalating dose study of short course (7 days) intranasal administration. We enrolled 18 PWS under 6 months old (6 each step) who received 4 IU either every other day, daily, or twice...
Sleep disturbances and the failure to entrain circadian rhythms 24-hour day have been reported in majority of totally blind subjects. The present case study a man with well-documented recurring sleep disturbance was designed investigate mutual relationship between timing system. 63-year-old subject, high school teacher regular work schedule, had suffered from cyclically insomnia for past 28 years. Analysis log that he kept 15 years suggested his were not entrained day. During 3-month...
A high proportion of human mammary cancers contain a measurable amount estrogen receptors. The presence receptors correlates well with the response patients to endocrine therapy, but not their chemotherapy. However, receptor-mediated chemotherapy should result in more selective and efficient treatment receptor-positive tumors. Several agents containing an estrogenic cytotoxic moiety have been synthesized past. It is surprising that affinity these compounds for estradiol receptor very low,...
Among older couples, spouses are first in line to provide care, and they key elements the home support of dependent persons. In this context, ensuring health these spousal caregivers should be an important issue for all providers who care adults. The aim study was longitudinally assess considering frailty, nutrition, cognition, physical performance mood disorders. longitudinal, observational cohort study, participants were assessed at Wallonia, Belgium. At baseline, 82 community-dwelling...
In central Europe, hemorrhagic fevers with renal syndrome (HFRS) in humans are caused by the hantavirus species Puumala (transmitted voles) and a second, Hantaan-related mice). The second virus could be identified as Dobrava virus. To date, 19 clinical cases of infection have been found Germany Slovakia. All patients exhibited mild/moderate course no case fatality occurred. Screening for infected rodents revealed that striped field mouse (Apodemus agrarius) represents main reservoir Europe....
The expression of insulin-like growth factor (IGF) and IGF receptor genes was investigated by RT-PCR during ontogeny the murine thymus. IGF-1, IGF-1R, M6P/IGF-2R are expressed in thymus both fetal postnatal life, whereas IGF-2 messenger RNAs (mRNAs) decline after birth but still detectable on seventh week. By situ hybridization, transcripts were located outer cortex medulla thymus, whole surface epithelial-like network effects anti-IGFs IGF-receptors neutralizing Abs generation pre-T cell...
Background Despite age-related adipose involution, T cell generation in the thymus (thymopoiesis) is maintained beyond puberty adults. In rodents, growth hormone (GH), insulin-like factor-1 (IGF-1), and GH secretagogues reverse changes cytoarchitecture increase thymopoiesis. administration also enhances thymic mass function HIV-infected patients. Until now, has not been investigated adult deficiency (AGHD). The objective of this clinical study was to evaluate AGHD, as well repercussion upon...
ABSTRACT Persistent replication of coxsackievirus B4 (CVB4) E2 (diabetogenic) and CVB4 JBV (nondiabetogenic) strains in thymic epithelial cell (TEC)-enriched cultures (≥95%) was proved by detection positive- negative-strand viral RNA reverse transcription-PCR extracted from cultures, VP1 capsid protein immunofluorescence (IF) staining, release infectious particles up to 30 days after infection without obvious cytolysis. By double-IF cytokeratin-containing cells were shown be susceptible...
Recent advances in the diagnostic of myeloproliferative neoplasms (MPNs) discovered CALRETICULIN (CALR) mutations as a major driver these disorders. In contrast to JAK2 being mainly associated with polycythaemia vera, CALR are only primary myelofibrosis (PMF) and essential thrombocythaemia (ET). present majority PMF ET patients lacking MPL mutations. As absent from reactive bone marrow (BM) lesions their presence indicates or PMF. So far detectable by molecular assays. Their detection is...
Insulin and multiple other autoantigens have been implicated in the pathogenesis of autoimmune type 1 diabetes, but origin immunological self-reactivity specifically oriented against insulin-secreting islet beta-cells remains obscure. The primary objective present study was to investigate hypothesis that a defect thymic central T-cell self-tolerance insulin hormone family could contribute pathophysiology diabetes. This investigated classic animal model Bio-Breeding (BB) rat.The expression...
<i>Aims:</i> We address the question of expression and role growth hormone/insulin-like factor (GH/IGF) axis in thymus. <i>Methods:</i> Using RT-qPCR, profile various components somatotrope GH/IGF was measured different thymic cell types during thymus embryogenesis Balb/c mice. The effect GH on T differentiation explored via organotypic culture. <i>Results:</i> Transcription <i>Gh</i>, <i>Igf1</i>, <i>Igf2</i> their...