A5035281956- Circadian rhythm and melatonin
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Parasites and Host Interactions
- Protein Kinase Regulation and GTPase Signaling
- Cancer Research and Treatments
- Health, Environment, Cognitive Aging
- Light effects on plants
- Photoreceptor and optogenetics research
- Antioxidant Activity and Oxidative Stress
- Acute Lymphoblastic Leukemia research
- Protein Tyrosine Phosphatases
- NF-κB Signaling Pathways
- Retinoids in leukemia and cellular processes
- Signaling Pathways in Disease
- Parasite Biology and Host Interactions
- Oral and Maxillofacial Pathology
- Probiotics and Fermented Foods
- Receptor Mechanisms and Signaling
- Cancer, Lipids, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Eicosanoids and Hypertension Pharmacology
- Histone Deacetylase Inhibitors Research
- Pharmacological Effects and Toxicity Studies
- Phytochemical and Pharmacological Studies
Polish Academy of Sciences
2024
University of Liège
2019-2023
Massachusetts General Hospital
2022-2023
Harvard University
2022-2023
Centre Hospitalier Universitaire de Liège
2020
University of Zurich
2013-2017
University of Basel
2015
University Hospital of Zurich
2015
Université de Perpignan
2008-2010
École Pratique des Hautes Études
2008-2010
Epigenetics, the science of heritable but modifiable information, is now a well-accepted component many research fields. Nevertheless, epigenetics has not yet found broad appreciation in one most exciting fields biology: comprehension evolution. This surprising, since reason for existence this alternative information-transmitting system lies certainly evolutionary advantage it provides. Theoretical considerations support model which epigenetic mechanisms allow increasing phenotypic...
The mammalian target of rapamycin complex 2 (mTORC2) contains the essential protein RICTOR and is activated by growth factors. mTORC2 in adipose tissue contributes to regulation glucose lipid metabolism. In perivascular tissue, ensures normal vascular reactivity controlling expression inflammatory molecules. To assess whether RICTOR/mTORC2 blood pressure regulation, we applied a radiotelemetry approach control Rictor knockout (Rictor(aP2KO)) mice generated using adipocyte protein-2 gene...
Circadian clock controls daily behavior and physiology. The activity of various signaling pathways affects gene expression. Here, we show that the core circadian CRY1 is a direct target Hippo pathway effector YAP. YAP binds to TEADs occupies proximal promoter regions CRY1, positively regulating its transcription. Interestingly, further identified acts in feedback loop fine-tune activation by modulating expression MOB1. Indeed, loss results enhanced activation. Consistently, found levels...
Phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P3) is required for protein kinase B (AKT) activation. The level of PI(3,4,5)P3 constantly regulated through balanced synthesis by phosphoinositide 3-kinase (PI3K) and degradation phosphatases phosphatase tensin homologue (PTEN) SH2-domain containing phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 (SHIP2), known as negative regulators AKT. Here, I show that SHIP2 inhibition in cervical cancer cell lines alters H2 O2 -mediated AKT...