A5103129758- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Treatment and Pharmacology
- Computational Drug Discovery Methods
- Sirtuins and Resveratrol in Medicine
- Phenothiazines and Benzothiazines Synthesis and Activities
- BRCA gene mutations in cancer
- Cholinesterase and Neurodegenerative Diseases
- Chemical synthesis and alkaloids
- Synthesis and Biological Evaluation
- Estrogen and related hormone effects
- Metal complexes synthesis and properties
- Multiple Myeloma Research and Treatments
- Synthesis and bioactivity of alkaloids
- Quinazolinone synthesis and applications
- Ferrocene Chemistry and Applications
- Receptor Mechanisms and Signaling
- Genomics, phytochemicals, and oxidative stress
- Click Chemistry and Applications
- Catalytic Cross-Coupling Reactions
- Multiple and Secondary Primary Cancers
- Pomegranate: compositions and health benefits
- Genetic factors in colorectal cancer
University of Basilicata
2022-2025
University of Calabria
2016-2025
University of Catania
2024
Health First
2018
Université de Caen Normandie
2007-2016
Centre d'Etudes et de Recherche sur le Médicament de Normandie
2007-2016
Centre National de la Recherche Scientifique
2008-2014
University of Rome Tor Vergata
2004-2013
University of Salerno
2010
University of Siena
2001-2003
Despite the progress achieved by anti-retroviral drug research in last decades, discovery of novel compounds endowed with selective antiviral activity and reduced side effects is still a necessity. At present, most urgent requirement includes improvement HIV (Human Immunodeficiency Virus) prevention sexual transmission development new drugs to treat chronic lifelong infection.Six chloro-1,4-dimethyl-9H-carbazoles (2a,b-4a,b) have been prepared following opportunely modified known chemical...
β-Caryophyllene (BCP), a natural bicyclic sesquiterpene, is selective phytocannabinoid agonist of type 2 receptors (CB2-R). It isn't psychogenic due to the absence an affinity cannabinoid receptor 1 (CB1). Among various biological activities, BCP exerts anti-inflammatory action via inhibiting main inflammatory mediators, such as inducible nitric oxide synthase (iNOS), Interleukin beta (IL-1β), Interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-α), nuclear factor kapp...
The multiple biological responses to estrogens are mainly mediated by the classical estrogen receptors ERα and ERβ, which act as ligand-activated transcription factors. exerts a main role in development of breast cancer; therefore, ER antagonist tamoxifen has been widely used although its effectiveness is limited de novo acquired resistance. Recently, GPR30/GPER, member seven-transmembrane G protein-coupled receptor family, implicated mediating effects various normal cancer cells. In...
The synthesis of an innovative delivery system for targeted cancer therapy which combines the drug controlled release ability Molecularly Imprinted Polymers (MIPs) with magnetic properties magnetite is described herein. In present study, easy and smart synthetic strategy, involving new engineered precipitation photo-polymerization, was developed aim to obtain Magnetic (MMIPs) 9H-carbazole derivative sustained in treatment. Both vitro cytotoxicity studies on different cell lines, such as HeLa...
Quercetin (Q1) is a flavonoid widely present in plants and endowed with several pharmacological properties mostly due to its antioxidant potential. Q1 shows anticancer activity could be useful cancer prevention. On the other hand, poorly soluble water unstable physiological systems, bioavailability very low.A small set of derivatives (Q2-Q9) has been synthesized following opportunely modified chemical procedures previously reported. Anticancer evaluated by MTT assay. Human Topoisomerases...
Abstract Cisplatin and other platinum‐based drugs are well‐known valid anticancer drugs. However, during chemotherapy, the presence of numerous side effects onset frequent phenomena resistance has pushed many research groups to devise new metal‐based compounds holding improved properties fewer undesired effects. Amongst variety synthesized compounds, significant antiproliferative have been obtained by employing organometallic particularly those based on silver gold. With this in mind, we...
Alzheimer’s disease (AD) is a progressive and age-related neurodegenerative disorder affecting brain cells the most common form of “dementia”, because cognitive detriment which takes place. Neuronal disruption represents its major feature, due to cytosolic accumulation amyloid β-peptide (Aβ) leads senile plaques formation intracellular neurofibrillary tangles. Many studies have focused on design therapeutic use new molecules able inhibit Aβ aggregation. In this context, we evaluated ability...
Synthetic or natural carbazole derivatives constitute an interesting class of heterocycles, which showed several pharmaceutical properties and occupied a promising place as antitumour tools in preclinical studies. They target cellular key-points, e.g. DNA Topoisomerases I II. The most studied representative, i.e. Ellipticine, was introduced the treatment metastatic breast cancer. However, because onset dramatic side effects, its use almost dismissed. Many efforts were made order to design...
Pomegranate is an old plant made up by flowers, roots, fruits and leaves, native to Central Asia principally cultivated in the Mediterranean California (although now widespread almost all over globe). The current use of this precious regards not only exteriority fruit (employed also for ornamental purpose) but especially nutritional and, still potential, health benefits that come out from various parts composing one (carpellary membranes, arils, seeds bark). Indeed, phytochemical composition...
This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds' structures were elucidated by NMR analysis their melting points measured. in vitro these compounds was tested evaluating amount scavenged ABTS radical estimating ROS NO production tBOH- or LPS-stimulated J774.A1 macrophages. All for effect on cell viability an MTT assay a Brine Shrimp Test.
ABSTRACT Alzheimer's disease is a neurodegenerative chronic with severe social and economic impact in the societies, which still lacks an efficient therapy. Several pathophysiological events ( β ‐amyloid [A ] deposits, τ ‐protein aggregation, loss of cholinergic activity, oxidative stress) occurs progression disease. Therefore, search for multi‐targeted agents treatment becomes indispensable. In this paper we evaluated AChE inhibition by Ellman's method antioxidant activity DPPH assay nine...
Abstract Chemotherapy is used for the treatment of all stages breast cancer, including metastatic stage disease. Treatment regimens are generally tailored each patient′s particular situation. However, chemotherapeutic agents leading cause serious drug‐related adverse effects; moreover, drug resistance often occurs. In this study, we designed and synthesized a new series N ‐alkylcarbazoles derived from ellipticine, an alkaloid with carbazole skeleton initially in cancer later dismissed...