A5016518336- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Essential Oils and Antimicrobial Activity
- Polysaccharides and Plant Cell Walls
- Microbial Metabolites in Food Biotechnology
- Synthesis and Biological Activity
- Cholinesterase and Neurodegenerative Diseases
- Bacterial biofilms and quorum sensing
- Polysaccharides Composition and Applications
- Synthetic Organic Chemistry Methods
- Natural product bioactivities and synthesis
- Biofuel production and bioconversion
- Agricultural Practices and Plant Genetics
- Enzyme Production and Characterization
- Postharvest Quality and Shelf Life Management
- Bioactive Compounds and Antitumor Agents
- Free Radicals and Antioxidants
- Antimicrobial Peptides and Activities
- Microbial Community Ecology and Physiology
- Seaweed-derived Bioactive Compounds
- Synthesis of Organic Compounds
- Echinoderm biology and ecology
- Enzyme function and inhibition
National Research Council
2015-2025
Istituto di Chimica Biomolecolare
2004-2019
National Academies of Sciences, Engineering, and Medicine
2011-2014
Consorzio Roma Ricerche
2010
University of Naples Federico II
1995-2007
Institute of Organic Chemistry with Centre of Phytochemistry
2000
Bulgarian Academy of Sciences
2000
Conventional agriculture relies on chemical pesticides and fertilizers, which can degrade ecosystems. A reduction of these harmful practices is required, replacing (or integrating) them with more eco-friendly approaches, such as microbial inoculation. Tomato an important agricultural product, a high content bioactive compounds (folate, ascorbate, polyphenols, carotenoids). The focus this research was to investigate the plant growth-promoting (PGP) abilities bacterial strains isolated from...
This study aimed to determine antiradical (DPPH• and •OH) acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total 38 phenolic compounds notable presence acids were identified using HPLC/MS-MS. Its water extract exhibited the highest activity against •OH (3.21 μg/mL), among rest due gallic, p-coumaric caffeic acids. At concentration 100 μg/mL, same displayed a profound AChE (60.53%) in liquid,...
The development of antimicrobial active packaging constitutes a powerful tool to reduce waste and increase quality standards perishable goods. Among numerous available agents, essential oils stand out for their renowned efficiency, use is beneficial due sustainability compared other oil-based antimicrobials. In this work, we report on the photo-responsive nanocapsules containing thyme oil as functional coatings polyethylene polylactic acid films obtain packaging. Polymer surface activation...
Eleven new thio-avarol derivatives (3−13) were synthesized. Their antimicrobial, brine shrimp lethality, and free-radical scavenging activities acetylcholinesterase inhibition, together with 12 already reported semisynthetic (14−25), evaluated. Structure−activity relationships among these thio determined.
ABSTRACT Alzheimer's disease is a neurodegenerative chronic with severe social and economic impact in the societies, which still lacks an efficient therapy. Several pathophysiological events ( β ‐amyloid [A ] deposits, τ ‐protein aggregation, loss of cholinergic activity, oxidative stress) occurs progression disease. Therefore, search for multi‐targeted agents treatment becomes indispensable. In this paper we evaluated AChE inhibition by Ellman's method antioxidant activity DPPH assay nine...
Among all metazoan phyla, sponges are known to produce the largest number of bioactive compounds. However, until now, only one compound, arabinofuranosyladenine, has been approved for application in humans. One major obstacle is limited availability larger quantities defined sponge starting material. Recently, we introduced vitro culture primmorphs from Suberites domuncula, which contain proliferating cells. Now have established primmorph also marine Dysidea avara and demonstrate that this...
This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds' structures were elucidated by NMR analysis their melting points measured. in vitro these compounds was tested evaluating amount scavenged ABTS radical estimating ROS NO production tBOH- or LPS-stimulated J774.A1 macrophages. All for effect on cell viability an MTT assay a Brine Shrimp Test.
Gastric cancer represents a diffuse and aggressive neoplasm, whose mortality index is among the highest in world. Predisposing factors are E-cadherin mutations, Helicobacter pylori infection, diet rich salted smoked food, with low intake of fresh fruits vegetables. Here, we analyzed effect total lipophilic extracts two Southern Italy tomato varieties, San Marzano Corbarino, on an vitro model gastric cancer, YCC-1, YCC-2 YCC-3 cell lines, characterized by different aggressiveness. Our results...
AbstractThe cytotoxicity of 4′-leucine-avarone, amino derivative the sponge Dysidea avara secondary metabolite avarone, was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay in vitro against seven human solid tumours for first time. The compound tested induced dose-dependent cytotoxic response all cancer cells showing better activity towards lung A-549 and colon HT-29 cell lines (IC50 7.40 μM 9.62 μM, respectively) than breast adenocarcinoma ER positive MCF-7...
The present review will explore the most relevant findings on marine microbial biofilm, with particular attention towards its polysaccharide fraction, namely exopolysaccharide (EPS). EPSs of origin are ubiquitous in nature, possess unique properties and can be isolated from bacteria living a variety habitats, including fresh water or environments, extreme environments different soil ecosystems. These biopolymers have many application field biotechnology. Several studies showed that biofilm...
Although the second biggest terrestrial group of plants, bryophytes remain poorly known chemically compared to angiosperms. In this article, sugars moss Rhodobryum ontariense, an unstudied representative medicinally genus, are reported. The chemical analysis revealed usual plant sugar sucrose, and a new sugar, fructooligosaccharide 1-kestose, which is reported first not only for genus Rhodobryum, but also mosses. trisaccharides have been scantily in hitherto. This gives more significance...
This work extends in vitro screening of antimicrobial activity the sesquiterpene hydroquinone avarol, a main secondary metabolite Mediterranean sponge species Dysidea avara. The was part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, included evaluation anti-quorum sensing (anti-QS) effects. At different extent avarol proven to be active all microorganisms tested (MIC 0.002-0.008 mg/mL MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 MFC 0.008-0.030...