A5023461815- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Medical Imaging and Pathology Studies
- Gastric Cancer Management and Outcomes
- Protein Structure and Dynamics
- Gallbladder and Bile Duct Disorders
- Cardiovascular and exercise physiology
- Antioxidant Activity and Oxidative Stress
- Ubiquitin and proteasome pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mitochondrial Function and Pathology
- Enzyme Structure and Function
- Viral Infectious Diseases and Gene Expression in Insects
- Glycosylation and Glycoproteins Research
- Phytochemicals and Antioxidant Activities
- Virus-based gene therapy research
- Pleural and Pulmonary Diseases
- DNA Repair Mechanisms
- Neuroendocrine Tumor Research Advances
Ollscoil na Gaillimhe – University of Galway
2024
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
1990-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2019
Institute of Biostructure and Bioimaging
2014-2018
University of Campania "Luigi Vanvitelli"
2016-2018
University of Naples Federico II
2013-2018
University of Siena
2014-2018
National Research Council
2016
Ente Ospedaliero Ospedali Galliera
1991-1993
Ospedale Civile Di Ivrea
1988
Serum concentrations of the CA 19-9 and 50 antigens were determined in 129 patients with malignant benign biliary pancreatic diseases. Values for two markers highly correlated (P < 0.001). The positive 84.6% 80.7% cancer, respectively. overall specificity (92.4%) was slightly higher than that (88.5%). sensitivity (91.3%) greater (73.9%) diseases tract. Elevated (12.9%) (35.2%) also found a number cases disease, especially obstructive jaundice. These data suggest both can be useful cancer...
Doxorubicin (doxo) is an effective anticancer compound in several tumor types. However, as a consequence of oxidative stress induction and ROS overproduction, its high cardiotoxicity demands urgent attention. Vanillin possesses antioxidant, antiproliferative, antidepressant anti-glycating properties. Therefore, we investigated the potential vanillin protective effects against doxo-induced H9c2 cells. Using multiparametric approach, demonstrated that restored both cell viability damage...
ABSTRACT The hepatitis C virus (HCV) E2 envelope glycoprotein is crucial for entry into hepatocytes. A conserved region of encompassing amino acids 412 to 423 (epitope I) and containing Trp420, a residue critical entry, recognized by several broadly neutralizing antibodies. Peptides embodying this epitope I sequence adopt β-hairpin conformation when bound monoclonal antibodies (MAbs) AP33 HCV1. We therefore generated new mouse MAbs that were able bind cyclic peptide residues 422 (C-epitope...
Aim of the present study was to test, by vitamin E treatment, hypothesis that muscle adaptive responses training are mediated free radicals produced during single exercise sessions. Therefore, we determined aerobic capacity tissue homogenates and mitochondrial fractions, content proteins expression factors (PGC-1, NRF-1, NRF-2) involved in biogenesis. Moreover, oxidative damage extent, antioxidant enzyme activities, glutathione both preparations, ROS production rate. Finally tested rate...
Gastric cancer represents a diffuse and aggressive neoplasm, whose mortality index is among the highest in world. Predisposing factors are E-cadherin mutations, Helicobacter pylori infection, diet rich salted smoked food, with low intake of fresh fruits vegetables. Here, we analyzed effect total lipophilic extracts two Southern Italy tomato varieties, San Marzano Corbarino, on an vitro model gastric cancer, YCC-1, YCC-2 YCC-3 cell lines, characterized by different aggressiveness. Our results...
Glioblastoma (GB) is the most common and aggressive malignant tumor of central nervous system. Despite current intensive treatment regimens, consisting surgical resection followed by radiotherapy with concomitant adjuvant temozolomide (TMZ) chemotherapy, prognosis patients GB remains extremely poor. Considering that alterations p53 suppressor pathway have a key role in both development resistance to TMZ treatment, re‑activation could be an effective therapeutic approach against GB. In this...
PPARs are a class of ligand-activated transcription factors belonging to the superfamily receptors for steroid and thyroid hormones, retinoids vitamin D that control expression large number genes involved in lipid carbohydrate metabolism regulation cell proliferation, differentiation death. The role CNS has been primarily associated with glucose metabolism; however, these also implicated neural death, as well neuronal maturation. Although it demonstrated play important roles determining NSCs...
We studied the effects of ten-day 1% Galdieria sulphuraria dietary supplementation on oxidative damage and metabolic changes elicited by acute exercise (6-hour swimming) determining oxygen consumption, lipid hydroperoxides, protein bound carbonyls in rat tissue (liver, heart, muscle) homogenates mitochondria, glutathione peroxidase reductase activities, content, rates H 2 O mitochondrial release. Exercise increased tissues mitochondria decreased content reduced glutathione. Moreover, it...
Recent structural investigations have shown that the C-terminal domain (CTD) of transcription factor RfaH undergoes unique modifications a profound impact into its functional properties. These cause complete change in RfaHCTD topology converts from an α-hairpin to β-barrel fold. To gain insights determinants this major conversion, we here performed computational studies (protein structure prediction and molecular dynamics simulations) on RfaHCTD. Although these analyses, line with literature...
The major cause of end-stage renal disease is the diabetic nephropathy. Oxidative stress contributes to development type II diabetes mellitus (T2DM). In this study we have evaluated effect a diet with new standardized red orange and lemon extract (RLE) rich in anthocyanins (ANT) progression kidney on Zucker fatty rats. function were analyzed. rats, RLE restored blood glucose levels, body weight, normalized reactive oxygen species (ROS) total pathways. inflammation, has not shown significant...
We studied vitamin E effects on metabolic changes and oxidative damage elicited by swim training in rat liver. Training reduced mitochondrial aerobic capacity but increased liver content of proteins, so that tissue was not different trained sedentary animals. Vitamin supplementation prevented the training-induced changes. were consistent with factors involved biogenesis (peroxisomal proliferator-activated receptor-γ coactivator nuclear respiratory 1 2). Tissue decreasing rate reactive oxygen...
Serum concentrations of the CA 19-9 tumour marker were determined in 35 patients with histologically proven bilio-pancreatic malignancies associated obstructive jaundice and benign extrahepatic due to choledocholithiasis. At a cut-off level 37 U/ml sensitivity this assay was 82.8%, but specificity very low (45.7%). Thus can not be employed differentiate between malignant jaundice. Serial samples achieved 7 6 biliary obstruction, before after disappearance tumour-antigen returned normal...
NONO is an RNA-binding protein involved in transcription, mRNA splicing, DNA repair, and checkpoint activation response to UV radiation. expression has been found altered several tumor types, including prostate, colon, breast, melanoma, papillary renal carcinoma, which X chromosome inversion generates a NONO-TFE3 fusion protein. Upon such rearrangement, loses its C-terminal domain. Through bioinformatics analysis, we identified putative degron motif, known be recognized by the...
We investigated whether reactive oxygen species (ROS) are involved in heart adaptive responses administering a vitamin E-enriched diet to trained rats. Using the homogenates and/or mitochondria from rat hearts we determined aerobic capacity, tissue level of mitochondrial proteins, and expression cytochrome c factors (PGC-1, NRF-1, NRF-2) biogenesis. also oxidative damage, glutathione peroxidase (GPX) reductase activities, content, ROS release rate, susceptibility vitro challenge. Glutathione...
The KCTD family is an emerging class of proteins that are involved in important biological processes whose biochemical and structural properties rather poorly characterized or even completely undefined. We here used KCTD5, the only member with a known three-dimensional structure, to gain insights into intrinsic stability C-terminal domain (CTD) mutual dynamic interplay between two domains protein. Molecular dynamics (MD) simulations indicate simulation timescale (120 ns), pentameric assembly...