A5016637397- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Occupational and environmental lung diseases
- Cancer Research and Treatments
- Antimicrobial Resistance in Staphylococcus
- RNA modifications and cancer
- Bacterial Identification and Susceptibility Testing
- RNA Research and Splicing
- Eosinophilic Disorders and Syndromes
- Reproductive tract infections research
- Chronic Myeloid Leukemia Treatments
- COVID-19 Clinical Research Studies
- Animal Disease Management and Epidemiology
- Medical Imaging and Pathology Studies
- Ocular Oncology and Treatments
- Immune Response and Inflammation
- Graphene and Nanomaterials Applications
- Immune responses and vaccinations
- Cancer therapeutics and mechanisms
- Ubiquitin and proteasome pathways
- Pneumonia and Respiratory Infections
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- DNA and Nucleic Acid Chemistry
- Cell death mechanisms and regulation
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2015-2021
University of Siena
2006-2015
Universidade Federal do Rio de Janeiro
2013
Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer, related to asbestos exposure, which has a dismal prognosis. MPM diagnosis late and often challenging, suggesting the need identify more reliable molecular biomarkers. Here, we set out differentially expressed miRNAs in epithelioid, biphasic, sarcomatoid MPMs versus normal mesothelium explored specific miRNA contribution mesothelial tumorigenesis. We screened LNA™-based miRNA-microrray with 14 formalin-fixed...
Abstract Background: Although immune-checkpoint inhibitors (ICIs) have positively impacted the treatment of some tumors, several evidences clearly suggest that actual relevance these treatments has not been fully unraveled yet Hypoxic tumors activate purinergic pathway, which acts as a major immunosuppressive mechanism. CD39 and CD73 are enzymes involved into ATP degradation to AMP immune-suppressive adenosine, respectively thus pathways progressively attracting attention actionable targets...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) belongs to the Beta-coronavirus genus. It is 96.2% homologous bat CoV RaTG13 and 88% two SARS-like coronaviruses. SARS-CoV-2 infectious agent responsible for coronavirus disease (COVID-19), which was first reported in Hubei province of Wuhan, China, at beginning December 2019. Human transmission from COVID-19 patients or incubation carriers occurs via coughing, sneezing, speaking, discharge nose, fecal contamination. Various...
UV radiations challenge genomic stability and are a recognized cancer risk factor. We previously found that the RNA-binding protein NONO regulates intra-S phase checkpoint its silencing impaired HeLa melanoma cell response to UV-induced DNA damage. Here we investigated mechanisms underlying regulation upon UVC treatment. rays induce expression of mir320a, which can indeed target NONO. However, despite mir320a induction, mRNA not affected by UVC. through RNA immunoprecipitation ubiquitous HUR...
ABSTRACT The antigen-specific primary activation of CD4 + T cells was studied in vivo by adoptive transfer ovalbumin-specific transgenic (KJ1-26 ) following intranasal immunization with recombinant Streptococcus gordonii . A strain S. expressing on its surface a model vaccine antigen fused to the ovalbumin (OVA) peptide from position 323 339 constructed and used study OVA-specific T-cell nasal mucosa-associated lymphoid tissue (NALT), lymph nodes, spleens mice immunized route. strain, but...
NONO is an RNA-binding protein involved in transcription, mRNA splicing, DNA repair, and checkpoint activation response to UV radiation. expression has been found altered several tumor types, including prostate, colon, breast, melanoma, papillary renal carcinoma, which X chromosome inversion generates a NONO-TFE3 fusion protein. Upon such rearrangement, loses its C-terminal domain. Through bioinformatics analysis, we identified putative degron motif, known be recognized by the...
A conserved fragment comprising amino acid residues 130–230 of the G glycoprotein human respiratory syncytial virus subtype was expressed in commensal bacterium Streptococcus gordonii. Recombinant streptococci displaying domain at cell surface were used to immunize mice via both parenteral and mucosal routes. Subcutaneous immunization induced virus-specific serum immunoglobin (IgG) capable partially controlling replication lungs. Intranasal with live bacteria stimulated production IgA...
Author Francesca Pentimalli was incorrectly associated with Histopathological Unit, IRCCS-Istituto Tumori “Giovanni Paolo II”, Viale Orazio Flacco 65, 70124 Bari, Italy. The author’s actual affiliation is Cell Biology and Biotherapy Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, I-80131 Napoli,