A5089216646- Cancer Immunotherapy and Biomarkers
- Melanoma and MAPK Pathways
- Colorectal Cancer Treatments and Studies
- Cancer-related cognitive impairment studies
- Cancer survivorship and care
- Advanced Breast Cancer Therapies
- Healthcare professionals’ stress and burnout
- Childhood Cancer Survivors' Quality of Life
- Click Chemistry and Applications
- COVID-19 and healthcare impacts
- CAR-T cell therapy research
- Workplace Health and Well-being
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Lung Cancer Treatments and Mutations
- Nursing education and management
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Dementia and Cognitive Impairment Research
- Cutaneous Melanoma Detection and Management
- Health Systems, Economic Evaluations, Quality of Life
Princess Alexandra Hospital
2023
Princess Alexandra Hospital
2019-2022
Cancer Australia
2021
Austin Health
2021
Arena Pharmaceuticals (United States)
2020
Queensland Health
2019
Positive reports of nursing-related outcomes such as quality nursing care, engagement with work and good practice environment are crucial in attaining maintaining Magnet® designation. The majority Magnet®-designated organisations (N = 482) the USA, their aggregate widely published benchmark data. Australian have not been aggregated or to date.The aims educational preparation, occupational burnout, job satisfaction, intention leave working nurses facilities determine reliability Practice...
Patients with late stage resected cutaneous melanoma have poor overall survival (OS) and experience irreversible adverse events from systemic therapy. There is a clinical need to identify biomarkers predict outcome. Performing germline/tumour whole-exome sequencing of 44 III/IV patients we identified pathogenic germline mutations in CDKN2A, CDK4, ATM, POLH, MRE11A, RECQL4 XPC, affecting 7/44 patients. These were associated OS (p = 0.0082). We confirmed our findings The Cancer Genome Atlas...
Studies indicate women aged 25-49 years previously treated for cancer report cognitive alterations. Good evidence indicates physical activity can be beneficial after and might additionally benefit function. This short presents data from a substudy of the Younger Women's Wellness Cancer Program (YWWACP), which explored alterations investigated potential associations between function in participants YWWACP. The primary aim this was to determine younger breast (1) whether subjectively reported...
10049 Background: Patients with advanced melanoma who progress on 1 st line TT and 2 nd IT have limited treatment options. We explored the safety efficacy of re-treatment 3 rd TT. Methods: was pooled from 6 centers in Australia 2009-2018. Eligible patients BRAF V600 mutant had therapy a BRAF/MEK inhibitor, IO were re-challenged inhibitor. Results: 90 included; median age 61 years, 78% V600E, 89% ECOG 0-1 at baseline. combination inhibitors 80%, predominately dabrafenib/trametinib. Response...
e21591 Background: Immune checkpoint inhibitors (CPI) are widely used in metastatic melanoma (MM), where it has markedly improved survival outcomes. ICI induced autoimmune adverse reactions (irAE) manifest all organ systems and due to over-activation of the immune system. Clinically relevant irAE colitis hepatitis as drivers morbidity mortality. Methods: Data was collected from a single centre (Princess Alexandra Hospital) electronic medical records system immunotherapy prescribing software....
e15039 Background: Next generation sequencing (NGS) technologies are increasingly employed to deliver optimal precision therapy for patients with cancer. The Molecular Screening and Therapeutics (MoST) study led by Prof David Thomas, Garvan Institute, Sydney, Australia, was established identify enrolment into clinical trials targeted or immune therapies not routinely indicated their illness, specifically focusing on those rare neglected malignancies more common that had completed standard...
e16033 Background: This is a retrospective analysis of outcomes in patients with oesophageal cancer treated either neoadjuvant or definitive CROSS chemoradiotherapy (CRT) at the Princess Alexandra Hospital between 2016-2020. Methods: Data was collected from single centre using electronic medical records system. Patient demographics, characteristics, treatments and were recorded. Results: 90 identified–75% male average age diagnosis 64 years. Higher tumour grade, nodal stage grade associated...
e21590 Background: Checkpoint inhibitor (CPI) use has been increasing in recent years. Immune related adverse events (irAEs) are a known complication of CPIs, particularly with the concurrent PD-1 and CTLA-4 inhibitors (combination therapy). IrAEs associated increased hospital resource utilisation including admissions immunomodulator therapy. This is retrospective analysis patients receiving CPI therapy for metastatic melanoma. Methods: Data was collected from Queensland Health centre using...
Background: Health professionals have reported significant reductions in cancer referrals during the COVID-19 pandemic.As national real-time incidence data were not available, Cancer Australia designed an approach to analysing Medicare Benefits Schedule (MBS) provide evidence on impact of pandemic cancerrelated services Australia.Methods: Over 500 MBS items for diagnostic and treatment procedures five highest cancers identified categorised into analysis groups based type and/or similarities...