A5083021667- Multiple Sclerosis Research Studies
- Anesthesia and Pain Management
- Systemic Lupus Erythematosus Research
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Management and Opioid Use
- Ocular Diseases and Behçet’s Syndrome
- Ultrasound Imaging and Elastography
- Airway Management and Intubation Techniques
- Neuroscience and Neuropharmacology Research
- Tracheal and airway disorders
- Pediatric Pain Management Techniques
- Peripheral Neuropathies and Disorders
- RNA regulation and disease
- Interpreting and Communication in Healthcare
- Enhanced Recovery After Surgery
- Intraperitoneal and Appendiceal Malignancies
- Rheumatoid Arthritis Research and Therapies
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Treatment and Pharmacology
- Spine and Intervertebral Disc Pathology
- Ion channel regulation and function
- Retinal and Optic Conditions
- Vestibular and auditory disorders
- Ureteral procedures and complications
- Opioid Use Disorder Treatment
The University of Texas Health Science Center at Houston
2024
The University of Texas MD Anderson Cancer Center
2017-2023
Data61
2023
Commonwealth Scientific and Industrial Research Organisation
2023
Centre Antoine Lacassagne
2022
Children's Hospital Colorado
2022
University of Colorado Denver
2022
Essen University Hospital
2022
Ospedale Santa Chiara
2022
University of Florida Health Science Center
2022
Brain atrophy measured by MRI is a potentially useful tool for monitoring disease progression in multiple sclerosis. The location, extent and mechanisms of brain early are not well documented. Using quantitative MRI, this study investigated whole brain, grey white matter clinically relapsing–remitting sclerosis its relationship to lesion measures. Data came from 27 normal control subjects (14 females 13 males, mean age 36.1 years) 26 with definite (18 eight 35.1 years, delay first symptom...
While much work has concentrated on focal white matter (WM) lesions in multiple sclerosis, there is growing evidence to suggest that normal‐appearing WM (NAWM) and grey (GM) are also involved the disease process. This study investigated sclerosis effects NAWM cortical GM (CGM) metabolite concentrations, relationships between these concentrations clinical impairment. Proton magnetic resonance spectroscopic imaging (1H‐MRSI) data acquired using point resolved (PRESS) localization (echo time 30...
Brain atrophy appears to occur in patients with multiple sclerosis (MS) excess of that associated normal ageing, and may be observed early the clinical course disease. The dynamics tissue specificity this process remain unclear. This preliminary study explored evolution brain grey matter (GM) white (WM) volume loss (as fractions total intracranial volumes) 13 subjects relapsing-remitting MS (mean disease duration 1.9 years at first scan), compared nine control (NC) subjects. Subjects were...
Treatment of acute optic neuritis with steroids has been shown to hasten visual recovery without affecting the final degree recovery. However, MRI-clinical studies indicate that patients long nerve lesions, particularly those involve within canal, may have a worse prognosis for vision. Partly because such lesions could lead swelling and subsequent ischemic damage, selective beneficial effect on this subgroup patients. The present randomized trial was designed test possibility. Sixty-six...
Ectopic action potentials can arise at regions of axonal demyelination, and are believed to contribute a range symptoms in patients with demyelinating conditions such as multiple sclerosis. The mechanism(s) by which the ectopic impulses generated uncertain. We have previously shown that activity result from inward potassium currents. Paradoxically, channel blocking agent 4-aminopyridine (4AP) sometimes cause lesions. To study this phenomenon we made intra-axonal recordings demyelinated...
Background Neuroaxonal loss is a pathological substrate of disability in progressive multiple sclerosis (MS) and can be estimated vivo by measuring tissue atrophy on magnetic resonance imaging (MRI). While there some evidence that brain correlates better with than T2 lesion load secondary MS, the clinical relevance within specific regions central nervous system requires further evaluation. Methods Clinical MRI examinations were performed 117 subjects MS. analysis included measures normalized...
Background Recently, ultrasound‐guided saphenous nerve blocks within and distal to the adductor canal have shown success. However, a potential side effect is an unintentional block of branches vastus medialis resulting in undesired motor weakness. Methods We dissected 40 embalmed cadaver thighs determine course relation medialis. Measurements were taken between various landmarks, descriptive statistics used present collected data. Results In 72.5% specimens, most visible branch pierced...
<h3>Background</h3> R<sub>2</sub>′ is an MRI measure of microscopic magnetic field inhomogeneity, and increased by the paramagnetic effect iron diamagnetic myelin. may detect features multiple sclerosis (MS) not evident with conventional MRI. <h3>Methods</h3> Multiecho T<sub>2</sub> T<sub>2</sub>* weighted sequences were obtained from 21 healthy controls (nine men, 12 women; mean age 36 years) 28 MS patients (seven 18 relapsing remitting, 10 secondary progressive; 42 years). relaxation time...
Premature vascular aneurysms and fragility of cerebral arteries are commonly associated with type III collagen mutations physical signs suggesting a generalized abnormality connective tissue. Sometimes these traits clearly genetically transmitted. Here we present seven examples early cerebrovascular or including five carotid cavernous sinus aneurysms. With one exception in which suspect the mutation is too small to be detected, all them had easily visible abnormalities their proteins....
<h3>Importance</h3> The opioid epidemic has reignited interest in opioid-sparing strategies managing pain. However, few studies have focused on use during perioperative care patients undergoing head and neck surgery with free flap reconstruction. <h3>Objectives</h3> To examine the association between multimodal analgesia (MMA) administration requirements reconstruction to investigate whether MMA alters duration of stay postanesthesia unit (PACU). <h3>Design, Setting, Participants</h3> In...
Language barriers can negatively impact the quality of healthcare. In surgical patients, limited English proficiency (LEP) lead to disparities in acute postoperative pain management. Interpreters are often used for communication with LEP patients help alleviate these disparities. We aimed investigate need language assistance services (LAS) management undergoing oncologic surgery. retrospectively collected data on adult open abdominal surgery between March 2016 and August 2021. The LAS,...
Objective To investigate the presence and evolution of T 1 relaxation time abnormalities in normal-appearing white matter (NAWM) grey (GM), early course relapsing–remitting multiple sclerosis (MS). Methods Twenty-three patients with MS 14 healthy controls were imaged six monthly for up to three years. Mean follow-up was 26 months 24 controls. Dual-echo fast-spin echo gradient-echo proton-density -weighted data sets (permitting calculation a map) acquired all subjects. GM NAWM histograms...
Abstract Background and Objectives The purpose of this study was to compare surgical outcomes before after implementation an enhanced recovery protocol (ERP) in gastrectomy for gastric cancer. Methods We included patients who underwent open cancer (January 2016 September 2018) or (October 2018 2020) ERP implementation. primary outcome the postoperative length stay (LOS). Secondary 90‐day readmission rates Clavien–Dindo grade ≥ 3 complications. Results One hundred (pre‐ERP group) 52 (ERP...