A5070457819- Gut microbiota and health
- Microscopic Colitis
- Mycobacterium research and diagnosis
- Colorectal Cancer Screening and Detection
- Healthcare innovation and challenges
- Migration, Aging, and Tourism Studies
- Geriatric Care and Nursing Homes
- Inflammatory Bowel Disease
- Clinical practice guidelines implementation
- Liver Diseases and Immunity
University of Birmingham
2023-2025
Abstract Background Resident intestinal macrophages play a key role in maintaining gut homeostasis and exhibit hypoactive tolerogenic phenotype. Recently, several subsets of have been identified based on CD11c expression which differ their inflammatory functional profiles. Notably, pro-inflammatory CD11c+ monocyte-like are found elevated patients with bowel disease (IBD), specifically Ulcerative colitis (UC) Crohn’s (CD). These cells recruited from blood monocytes via the CCR2/CCL2 chemokine...
Abstract Background Gut microbiome disruption is an established characteristic of IBD. The lack treatment naïve longitudinal data makes it challenging to separate the influence potential confounders. We present detailed stool metagenomics analysis from a cohort IBD patients seen in our rapid-access inception clinic. Methods Stool collected DNA Genotek OM-200 kits was pre-diagnosis, alongside faecal calprotectin (FCP). Microbial extracted. Libraries were prepared using NEBNext Ultra II FS...
Abstract Background Gut microbiome disruption and ‘dysbiosis’ is an established characteristic of IBD. The lack treatment naïve prospective longitudinal data makes it challenging to separate the influence potential confounders. We present our preliminary microbiota analysis from a cohort IBD patients seen in rapid-access integrated clinical research inception clinic. Methods Stool collected DNA Genotek OM-200 kits brought first face pre-diagnosis outpatient review, alongside faecal...