The effects of sagittal kyphotic deformities or mechanical stress on the development cervical spondylotic myelopathy, reduction and fusion alignment have not been consistently documented. aim in this study was to determine spine terms neurological morbidity outcome after 2 types surgical intervention.The authors retrospectively reviewed records 476 patients who underwent surgeries for myelopathy between 1993 2006 at their university medical center. Among these were identified 43 patients-30...

Object In this paper the authors' goal was to identify histological and immunohistochemical differences between cervical disc herniation spondylosis. Methods A total of 500 intervertebral discs were excised from 364 patients: 198 patients with 166 We examined en bloc samples endplate-ligament-disc complexes. Types graded degrees degeneration on MR images histologically immunohistochemically. Results The herniated showed granulation tissue, newly developed blood vessels, massive infiltration...

Object. The object of this study was to histopathologically and immunohistochemically characterize ossification the ligamentum flavum (OLF) in samples thoracic spine harvested en bloc during surgery enhance understanding ossifying process, particularly calcification ossification. Methods. Samples OLF plaque were obtained from 43 patients who underwent posterior decompression. histopathological findings correlated with radiological subtypes using computed tomography. expression type I II...

In Brief Study Design. To examine the effects of a tumor necrosis factor (TNF)-α antagonist (etanercept) on rat spinal cord injury and identify possible mechanism for its action. Objective. elucidate contribution etanercept to pathologic cascade in suppression neuronal oligodendroglial apoptosis. Summary Background Data. Etanercept has been recently used successfully treatment inflammatory disorders. However, only few studies have examined role suppressing apoptosis injury. Methods. or...

Osteoporosis represents a significant side effect of glucocorticoid therapy, and alendronate has been reported to prevent this glucocorticoid-induced osteoporosis. Functional imaging with (18)F-fluoride PET allows quantitative analysis bone metabolism in specific skeletal regions. However, only few studies have quantitatively determined turnover osteoporosis by radiologic techniques including PET. The aim study was examine changes regional remodeling as measured PET, the relationship between...

Object The surgical approach and treatment of thoracolumbar osteoporotic vertebral collapse with neurological deficit have not been documented in detail. Anterior surgery provides good decompression solid fusion, but the surgery-related risk is relatively higher than that associated posterior approach. In surgery, major problem after correction instrumentation failure to support anterior spinal column, leading loss kyphosis. aim this study was evaluate efficacy reinforcing short-segment...

The mechanisms responsible for the spontaneous regression of lumbar disc herniation (LDH) were studied by examining herniated tissue collected at operation from patients with LDH.The aim present study was to investigate role neovascularization and macrophages in hernias when LDH occurred.Spontaneous LDHs has already been demonstrated diagnostic imaging tools such as magnetic resonance imaging. However, there have few studies on based pathologic examination tissue. In particular, no detailed...

Histologic and immunohistochemical studies after targeted retrograde adenovirus (AdV)-mediated brain-derived neurotrophic factor (BDNF) gene delivery via intramuscular injection in rats with injured spinal cord.To investigate the neuroprotective effect of AdV-BDNF transfection traumatically cord terms prevention apoptosis neurons oligodendrocytes.Several investigated effects neurotrophins including BDNF on injury, respect to neural cell cord. However, no report has described potential...

Abstract Introduction Ossification of the ligamentum flavum (OLF) spine is associated with serious neurologic compromise, but pathomechanism this process remains unclear. The objective study was to investigate ossification process, including roles various transcriptional factors in human thoracic flavum. Methods Sections were obtained from 31 patients OLF who underwent posterior decompression, and six control free OLF. Cultured cells ( n = 6, each) examined real-time reverse...

In Brief Study Design. To examine the localization and expression of high-mobility group box-1 (HMGB-1) protein its receptors after rat spinal cord injury. Objective. elucidate contribution HMGB-1 as potential candidates in a specific upstream pathway to proinflammatory response leading cascade secondary tissue damage Summary Background Data. was recently characterized key cytokine with role nucleosome formation regulation gene transcription. No studies have investigated Methods. Injured...

Object The authors investigated the usefulness of using an expandable cage strut in anterior reconstruction after osteoporotic vertebral collapse patients with neurological deficits. Methods Twenty-eight who had undergone strut–augmented thoracolumbar participated a follow-up review for mean 4.9 years. Radiographs were reviewed kyphosis, lateral tilt implant, subsidence, presence solid fusion mass, and instrumentation failure. Changes status visual analog scale (VAS) pain score, as well...

This study examined the effect of lumbar nerve root compression on nociceptive neuropeptides in axonal flow using an vivo model.The aim was to investigate changes after by immunohistochemical techniques detect substance P (SP) and somatostatin (SOM), which is thought be involved temperature pain sensation.Disturbance intraradicular blood fiber deformation caused mechanical are pathophysiology diseases characterized radicular symptoms, such as disc herniation canal stenosis. However, little...

In Brief Study Design. To examine the distribution of apoptotic cells and expression tumor necrosis factor (TNF)-α its receptors in spinal hyperostotic mouse (twy/twy) with chronic cord compression using immunohistochemical methods. Objective. study mechanisms apoptosis, particularly oligodendrocytes, which could contribute to degenerative change demyelination mechanical compression. Summary Background Data. TNF-α acts as an external signal initiating apoptosis neurons oligodendrocytes after...

In Brief Study Design. Histological, immunohistochemical, and real-time reverse transcription-polymerase chain reaction analyses of the expression cell signaling transcriptional factors in human ossification ligamentum flavum (OLF). Objective. To test hypothesis that β-catenin plays a role OLF cells response to cyclic tensile strain. Summary Background Data. Several studies have investigated roles biomechanical metabolic development progression OLF, based on importance genetic biological...

Object. The authors studied the histological and immunohistochemical features of ossified posterior longitudinal ligament (PLL) cervical spine, especially in calcification ossification front. Methods. Samples en bloc PLL plaque obtained 31 patients were stained with H & E immuno-histochemically prepared for collagens (types I II), vascular endothelial growth factor (VEGF), transforming (TGF)–β, bone morphogenetic protein (BMP)–2, by terminal deoxynucleotidyl transferase–mediated...

In Brief Study Design. This study is aimed to investigate the changes of nerve root functions during straight leg raising (SLR) test in vivo. Objective. To relationship between movement and electrophysiological values an intraoperative SLR test. Summary Background Data. The one most significant signs for making a clinical diagnosis lumbar disc herniation. A recent showed that intraradicular blood flow apparently decreased patients with Methods. included 32 who underwent microdiscectomy....

Histological, immunohistochemical, and immunoblot analyses of the expression Indian hedgehog (Ihh) signaling in human cervical ossification posterior longitudinal ligament (OPLL).To examine hypothesis that Ihh correlation with Sox9 parathyroid-related peptide hormone (PTHrP) facilitates chondrocyte differentiation enchondral process OPLL.In ossification, certain transcriptional factors regulate cell differentiation. OPLL is characterized by overexpression these disturbance normal process....

Abstract The development of radiculopathy in patients with lumbar canal stenosis is thought to be closely related intraradicular edema resulting from compression. However, there little agreement as question which more essential for intermittent claudication: ischemia or congestion. aim the present experimental investigation was examine effect and congestion on nerve root using dogs. aorta clamped an model inferior vena cava a at sixth costal level 30 min forceps transpleurally. Measurements...