A5103239753- IL-33, ST2, and ILC Pathways
- Infant Nutrition and Health
- Congenital Diaphragmatic Hernia Studies
- Eosinophilic Esophagitis
- Neonatal Respiratory Health Research
- Gastroesophageal reflux and treatments
University of Pittsburgh
2021
Children's Hospital of Pittsburgh
2020
Necrotizing enterocolitis (NEC) is a severe gastrointestinal complication of prematurity. Using suspension and imaging mass cytometry coupled with single-cell RNA sequencing, we demonstrate inflammation in patients NEC. NEC mucosa could be subtyped by an influx three distinct neutrophil phenotypes (immature, newly emigrated, aged). Furthermore, CD16+CD163+ monocytes/Mϕ, correlated emigrated neutrophils, were specifically enriched mucosa, found adjacent to the blood vessels, increased...
Although histologic features in biopsies suggesting a possibility of achalasia would be helpful diagnostically, such remain unknown. The goal this study was to explore the prevalence, features, and immunophenotype lymphocytic esophagitis (LyE) biopsies.The group consisted 57 patients with achalasia. Controls comprised 52 severe gastroesophageal reflux disease (GERD) normal esophageal motility. CD4/CD8 lymphocytes analyzed by immunohistochemistry.LyE identified 30% (17/57) 6% (3/52) GERD,...