A5038362988- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- T-cell and B-cell Immunology
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Congenital Diaphragmatic Hernia Studies
- Dermatology and Skin Diseases
Boston Children's Hospital
2019-2021
Ulcerative colitis (UC) represents an inflammatory condition of the human colon believed in part to be mediated by dysregulation host immune system including potentially inadequate mucosal regulatory T-cell (Treg) responses.1Chang J.T. N Engl J Med. 2020; 383: 2652-2664Crossref PubMed Scopus (445) Google Scholar,2Laukova M. Glatman Zaretsky A. Eur Immunol. 2023; 53e2250007Crossref (8) Scholar Low-dose (LD) interleukin 2 (IL2) has been shown expand peripheral Tregs and ameliorate various...
Necrotizing enterocolitis (NEC) is a severe gastrointestinal complication of prematurity. Using suspension and imaging mass cytometry coupled with single-cell RNA sequencing, we demonstrate inflammation in patients NEC. NEC mucosa could be subtyped by an influx three distinct neutrophil phenotypes (immature, newly emigrated, aged). Furthermore, CD16+CD163+ monocytes/Mϕ, correlated emigrated neutrophils, were specifically enriched mucosa, found adjacent to the blood vessels, increased...
Abstract Background The gut microbiome is altered in patients with inflammatory bowel disease, yet how these alterations contribute to intestinal inflammation poorly understood. Murine models have demonstrated the importance of colitis since fails develop many genetically susceptible animal when re-derived into germ-free environments. We previously shown that Wiskott-Aldrich syndrome protein (WASP)-deficient mice ( Was −/− ) spontaneous colitis, similar human loss-of-function mutations WAS ....
Abstract Background A significant proportion of patients with ulcerative colitis (UC) have suboptimal responses to medical therapy. Expansion regulatory T cells (Tregs), but not conventional (Tcons), through the use low doses (LD) cell growth factor Interleukin-2 (IL-2, Proleukin®), has been a promising approach in other immune-mediated diseases and pre-clinical humanized UC mouse models. We performed phase 1b/2a clinical trial moderate-to-severe determine if subcutaneously (SC) administered...
Patients with inflammatory bowel disease (IBD) have altered intestinal microbial composition, but whether this microbiota is a cause or consequence of inflammation unclear. The importance the gut in IBD pathogenesis has been shown many murine models, since colitis fails to develop genetically-susceptible mice when re-derived into germ-free environments. Wiskott-Aldrich syndrome protein (WASP)-deficient (Was-/-) exhibit immune dysregulation and IBD, similar human patients mutations WAS. that...