A5073820305- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Organophosphorus compounds synthesis
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Herpesvirus Infections and Treatments
- Toxin Mechanisms and Immunotoxins
- Crystallography and molecular interactions
- Phosphorus compounds and reactions
- Research on Leishmaniasis Studies
- Synthesis and biological activity
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Reactions
Wrocław University of Science and Technology
2014-2023
AGH University of Krakow
2017-2023
Faculty (United Kingdom)
2019-2020
Wroclaw University of Applied Informatics "Horizon"
2018
Herpes simplex virus type 1 (HSV-1) is a widespread human pathogen known to cause infections of diverse severity, ranging from mild ulceration mucosal and dermal tissues life-threatening viral encephalitis. In most cases, standard treatment with acyclovir sufficient manage the disease progression. However, emergence ACV-resistant strains drives need for new therapeutics molecular targets. HSV-1 VP24 protease indispensable assembly mature virions and, as such, constitutes an interesting...
New chiral tetrasubstituted aminophosphonic acid derivatives of hexahydroquinoxalin-2(1H)-one were synthesised via highly diastereoselective hydrophosphonylation the corresponding imines with tris(trimethylsilyl) phosphite as phosphorus nucleophile. High asymmetric induction, good yields, mild reaction conditions, and ease purification final products are key advantages presented protocol.
New chiral bicyclic imines, enamines and amines were prepared via Horner-Wadsworth-Emmons reaction of hexahydroquinoxalin-2(1H)-one-derived phosphonate, as the source a phosphonate carbanion, wide range structurally diverse carbonyl substrates. The simplicity synthetic protocol, high selectivity, broad substrate scope are main advantages presented methodology.
In the search for new antitumor agents, aminophosphonic acids and their derivatives based on octahydroquinoxalin-2(1H)-one scaffold were obtained cytotoxic properties a mechanism of action evaluated. Phosphonic acid phosphonate moieties increased antiproliferative activity in comparison to phenolic Mannich bases previously reported. Most compounds revealed strong effect against leukemia cell line (MV-4-11) with simultaneous low cytotoxicity normal (mouse fibroblasts-BALB/3T3). The most...
N-Heterocycles are considered as desirable scaffolds for the development of novel lead compounds anticancer drug research. Among them, phosphorus-containing amino-derivatives play a crucial role. A series imines and products their further reactions with P-nucleophiles were obtained starting from vicinal bisamines. Reaction ethylenediamine α-carbonyl esters yielded in unexpected products, which structures confirmed by crystallographic measurements. The cytotoxic activity evaluation was done...