A5018058921- Herpesvirus Infections and Treatments
- Hepatitis C virus research
- Peptidase Inhibition and Analysis
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- Protease and Inhibitor Mechanisms
- Click Chemistry and Applications
- Organophosphorus compounds synthesis
- Hepatitis B Virus Studies
- Photochemistry and Electron Transfer Studies
- Research on Leishmaniasis Studies
- HIV/AIDS drug development and treatment
- Carbohydrate Chemistry and Synthesis
- Viral Infections and Immunology Research
- Systemic Lupus Erythematosus Research
- Virus-based gene therapy research
- Diverse Scientific Research Studies
- Fluorine in Organic Chemistry
- Cell Adhesion Molecules Research
- Molecular Sensors and Ion Detection
- Cerebrovascular and genetic disorders
- Synthesis and Catalytic Reactions
- Animal health and immunology
- Antimicrobial Resistance in Staphylococcus
- Studies on Chitinases and Chitosanases
KU Leuven
2024
Wrocław University of Science and Technology
2012-2023
AGH University of Krakow
2016-2023
Łukasiewicz Research Network – PORT Polish Center for Technology Development
2021-2023
Łukasiewicz Research Network
2021
Weatherford College
2014
Herpes simplex virus type 1 (HSV-1) is a widespread human pathogen known to cause infections of diverse severity, ranging from mild ulceration mucosal and dermal tissues life-threatening viral encephalitis. In most cases, standard treatment with acyclovir sufficient manage the disease progression. However, emergence ACV-resistant strains drives need for new therapeutics molecular targets. HSV-1 VP24 protease indispensable assembly mature virions and, as such, constitutes an interesting...
A high photoluminescence quantum yield is reported for the first time in diketofurofuran dye and a thermofluorochromic dye-doped liquid crystal system proposed.
West Nile virus (WNV) is a member of the flavivirus genus belonging to Flaviviridae family. The viral serine protease NS2B/NS3 has been considered an attractive target for development anti-WNV agents. Although several inhibitors have described so far, most them are reversible inhibitors. Herein, we present series α-aminoalkylphosphonate diphenyl esters and their peptidyl derivatives as potent protease. inhibitor identified was Cbz-Lys-Arg-(4-GuPhe)P(OPh)2 displaying Ki k2/Ki values 0.4 µM 28...
The neutrophilic serine protease proteinase 3 (PR3) is involved in inflammation and immune response thus appears as a therapeutic target for variety of infectious inflammatory diseases. Here we combined kinetic molecular docking studies to increase the potency peptidyl-diphenyl phosphonate PR3 inhibitors. Occupancy S1 subsite by nVal residue S4–S5 subsites biotinylated Val obtained biotin-VYDnVP(O-C6H4-4-Cl)2 enhanced second-order inhibition constant kobs/[I] toward more than 10 times...
In order to productively infect a host, viruses must enter the cell and force host replication mechanisms produce new infectious virus particles. The success of this process unfortunately results in disease progression and, case infection with many viral species, may cause mortality. discoveries Louis Pasteur Edward Jenner led one greatest advances modern medicine - development vaccines that generate long-lasting memory immune responses combat infection. Widespread use has reduced mortality...
The identification and characterization of the four active neutrophil serine proteases (NSPs) have provided a better understanding their roles in various physiological pathological processes. availability appropriate tools such as substrates, inhibitors, activity-based probes (ABPs) for studying activity functions cells has become increasingly important. In this paper, authors provide comprehensive overview current state knowledge on available NSPs. ABPs that been developed to date are...
ABSTRACT The IgY antibodies offer an attractive alternative to mammalian IgGs in research, diagnosis and medicine. isolation of immunoglobulin Y from the egg yolks is efficient economical, causing minimal suffering animals. Here we present methodology for production specific Staphylococcus aureus fibrinogen binding protein (Efb) its peptidyl epitope (spanning residues 127–140). Efb extracellular, adhesion which binds both human complement C3 thus contributing high infectious potential this...
Although the mosquito-borne Zika virus was discovered in late 1940s of 20th century, for years it neglected, as disease humans rare and relatively mild. Viral NS2B-NS3 protease is essential replication, except maturation viral proteins, also modulates infection microenvironment to facilitate invasion. Here, we report combinatorial chemistry approach synthesis internally quenched substrates that were optimized prime positions peptide chain. Final substrate...
This paper presents a comparison of the simultaneous preparation di-O-alkylated and ether-ester derivatives fluorescein using different methods (conventional or microwave heating). Shortening reaction time increased efficiency were observed when reactor. Moreover, described here for first is application fast, simple, eco-friendly ball-assisted method to exclusively obtain derivatives. We also demonstrate that can be effectively functionalized by O-alkylation carried out under ball-milling...
In order to productively infect a host, viruses must enter the cell and force host replication mechanisms produce new infectious virus particles. The success of this process unfortunately results in disease progression and, case infection with many viral species, may cause mortality. discoveries Louis Pasteur Edward Jenner led one greatest advances modern medicine - development vaccines that generate long-lasting memory immune responses combat infection. Widespread use has reduced mortality...
Herein, we report selection, synthesis, and enzymatic evaluation of a peptidomimetic library able to increase proteolytic activity HtrA3 (high temperature requirement A) protease. Iterative deconvolution in solution synthesized modified pentapeptides yielded two potent activators acting the micromolar range (HCOO-CH2O-C6H4-OCH2-CO-Tyr-Asn-Phe-His-Asn-OH HCOO-CH2O-C6H4-OCH2-CO-Tyr-Asn-Phe-His-Glu-OH). Both compounds increased proteolysis an artificial substrate over 40-fold selective manner....
Abstract Two similar one‐pot procedures are presented for the synthesis of title compounds (IV).